The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy
γδ T cells are a distinct subset of T cells whose T cell receptors consist of γ chains and δ chains, different from conventional αβ T cells. γδ T cells are considered as a member of the innate immunity because of their non-MHC restricted antigen recognition, rapid response to invading pathogens and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-05-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/5/1206 |
| _version_ | 1797568156671148032 |
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| author | Yuxia Liu Cai Zhang |
| author_facet | Yuxia Liu Cai Zhang |
| author_sort | Yuxia Liu |
| collection | DOAJ |
| description | γδ T cells are a distinct subset of T cells whose T cell receptors consist of γ chains and δ chains, different from conventional αβ T cells. γδ T cells are considered as a member of the innate immunity because of their non-MHC restricted antigen recognition, rapid response to invading pathogens and sense early changes of malignant cells. Upon activation, they can further promote the activation of adaptive immune cells, such as T cells and B cells, by secreting various cytokines. Thus, γδ T cells are regarded as a bridge between innate immunity and acquired immunity. γδ T cells are involved in a variety of immune response processes, including immune defense and immune surveillance against infection and tumorigenesis. γδ T cells recognize multiple tumor-associated antigens or molecules in T cell receptors (TCRs)-dependent and natural killer cell receptors (NKRs)-dependent ways. γδ T cells not only display a direct killing capacity on a variety of tumors, but also exert anti-tumor immune responses indirectly by facilitating the function of other immune cells, such as dendritic cells (DCs), B cells and CD8<sup>+</sup> T cells. In this review, we summarize the major subpopulations, the tumor recognition mechanisms, and the anti-tumor effects of human γδ T cells, particularly the potential of γδ T cells for cancer immunotherapy. |
| first_indexed | 2024-03-10T19:52:28Z |
| format | Article |
| id | doaj.art-5026406d37574e3baf3d1694849bbeb8 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:52:28Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-5026406d37574e3baf3d1694849bbeb82023-11-20T00:15:23ZengMDPI AGCells2073-44092020-05-0195120610.3390/cells9051206The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer ImmunotherapyYuxia Liu0Cai Zhang1Institute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhua West Road, Jinan 250012, ChinaInstitute of Immunopharmaceutical Sciences, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, 44 Wenhua West Road, Jinan 250012, Chinaγδ T cells are a distinct subset of T cells whose T cell receptors consist of γ chains and δ chains, different from conventional αβ T cells. γδ T cells are considered as a member of the innate immunity because of their non-MHC restricted antigen recognition, rapid response to invading pathogens and sense early changes of malignant cells. Upon activation, they can further promote the activation of adaptive immune cells, such as T cells and B cells, by secreting various cytokines. Thus, γδ T cells are regarded as a bridge between innate immunity and acquired immunity. γδ T cells are involved in a variety of immune response processes, including immune defense and immune surveillance against infection and tumorigenesis. γδ T cells recognize multiple tumor-associated antigens or molecules in T cell receptors (TCRs)-dependent and natural killer cell receptors (NKRs)-dependent ways. γδ T cells not only display a direct killing capacity on a variety of tumors, but also exert anti-tumor immune responses indirectly by facilitating the function of other immune cells, such as dendritic cells (DCs), B cells and CD8<sup>+</sup> T cells. In this review, we summarize the major subpopulations, the tumor recognition mechanisms, and the anti-tumor effects of human γδ T cells, particularly the potential of γδ T cells for cancer immunotherapy.https://www.mdpi.com/2073-4409/9/5/1206γδ T cellsanti-tumor effectcancer immunotherapy |
| spellingShingle | Yuxia Liu Cai Zhang The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy Cells γδ T cells anti-tumor effect cancer immunotherapy |
| title | The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy |
| title_full | The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy |
| title_fullStr | The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy |
| title_full_unstemmed | The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy |
| title_short | The Role of Human γδ T Cells in Anti-Tumor Immunity and Their Potential for Cancer Immunotherapy |
| title_sort | role of human γδ t cells in anti tumor immunity and their potential for cancer immunotherapy |
| topic | γδ T cells anti-tumor effect cancer immunotherapy |
| url | https://www.mdpi.com/2073-4409/9/5/1206 |
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