Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate
The generation of reactive oxygen species (ROS) and an imbalance of antioxidant defence mechanisms can result in oxidative stress. Several pro-atherogenic stimuli that promote intimal-medial thickening (IMT) and early arteriosclerotic disease progression share oxidative stress as a common regulatory...
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-11-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/6/4/90 |
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| author | Denise Burtenshaw Roya Hakimjavadi Eileen M. Redmond Paul A. Cahill |
| author_facet | Denise Burtenshaw Roya Hakimjavadi Eileen M. Redmond Paul A. Cahill |
| author_sort | Denise Burtenshaw |
| collection | DOAJ |
| description | The generation of reactive oxygen species (ROS) and an imbalance of antioxidant defence mechanisms can result in oxidative stress. Several pro-atherogenic stimuli that promote intimal-medial thickening (IMT) and early arteriosclerotic disease progression share oxidative stress as a common regulatory pathway dictating vascular cell fate. The major source of ROS generated within the vascular system is the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes (Nox), of which seven members have been characterized. The Nox family are critical determinants of the redox state within the vessel wall that dictate, in part the pathophysiology of several vascular phenotypes. This review highlights the putative role of ROS in controlling vascular fate by promoting endothelial dysfunction, altering vascular smooth muscle phenotype and dictating resident vascular stem cell fate, all of which contribute to intimal medial thickening and vascular disease progression. |
| first_indexed | 2024-03-12T19:45:06Z |
| format | Article |
| id | doaj.art-50266b9ea6e9408b98185193c0f0fb24 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:45:06Z |
| publishDate | 2017-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-50266b9ea6e9408b98185193c0f0fb242023-08-02T03:34:28ZengMDPI AGAntioxidants2076-39212017-11-01649010.3390/antiox6040090antiox6040090Nox, Reactive Oxygen Species and Regulation of Vascular Cell FateDenise Burtenshaw0Roya Hakimjavadi1Eileen M. Redmond2Paul A. Cahill3Vascular Biology & Therapeutics, School of Biotechnology, Dublin City University, D09NR58 Dublin, IrelandVascular Biology & Therapeutics, School of Biotechnology, Dublin City University, D09NR58 Dublin, IrelandDepartment of Surgery (Research), University of Rochester Medical Centre, Rochester, NY 14620, USAVascular Biology & Therapeutics, School of Biotechnology, Dublin City University, D09NR58 Dublin, IrelandThe generation of reactive oxygen species (ROS) and an imbalance of antioxidant defence mechanisms can result in oxidative stress. Several pro-atherogenic stimuli that promote intimal-medial thickening (IMT) and early arteriosclerotic disease progression share oxidative stress as a common regulatory pathway dictating vascular cell fate. The major source of ROS generated within the vascular system is the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase family of enzymes (Nox), of which seven members have been characterized. The Nox family are critical determinants of the redox state within the vessel wall that dictate, in part the pathophysiology of several vascular phenotypes. This review highlights the putative role of ROS in controlling vascular fate by promoting endothelial dysfunction, altering vascular smooth muscle phenotype and dictating resident vascular stem cell fate, all of which contribute to intimal medial thickening and vascular disease progression.https://www.mdpi.com/2076-3921/6/4/90NoxROSvascular smooth muscleendothelialstem cellsadventitial cellsarteriosclerotic diseaseintimal-medial thickening |
| spellingShingle | Denise Burtenshaw Roya Hakimjavadi Eileen M. Redmond Paul A. Cahill Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate Antioxidants Nox ROS vascular smooth muscle endothelial stem cells adventitial cells arteriosclerotic disease intimal-medial thickening |
| title | Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate |
| title_full | Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate |
| title_fullStr | Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate |
| title_full_unstemmed | Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate |
| title_short | Nox, Reactive Oxygen Species and Regulation of Vascular Cell Fate |
| title_sort | nox reactive oxygen species and regulation of vascular cell fate |
| topic | Nox ROS vascular smooth muscle endothelial stem cells adventitial cells arteriosclerotic disease intimal-medial thickening |
| url | https://www.mdpi.com/2076-3921/6/4/90 |
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