Hypervirulent Klebsiella pneumoniae
Junjun Chen,1,2 Huan Zhang,1,3 Xuelian Liao1,2 1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, West China Tianfu Hospital of Sichuan University, Chengdu, People’s Republic of China; 3Departmen...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-08-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/hypervirulent-klebsiella-pneumoniae-peer-reviewed-fulltext-article-IDR |
| _version_ | 1797743850458972160 |
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| author | Chen J Zhang H Liao X |
| author_facet | Chen J Zhang H Liao X |
| author_sort | Chen J |
| collection | DOAJ |
| description | Junjun Chen,1,2 Huan Zhang,1,3 Xuelian Liao1,2 1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, West China Tianfu Hospital of Sichuan University, Chengdu, People’s Republic of China; 3Department of Cardiac Vascular Surgery Critical Care Medicine, The Third People’s Hospital of Chengdu, Chengdu, People’s Republic of ChinaCorrespondence: Xuelian Liao, Department of Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, People’s Republic of China, Tel +8613541023033, Email xuelianliao@hotmail.comAbstract: Hypervirulent Klebsiella pneumoniae (hvKP), especially multidrug-resistant hvKP (MDR-hvKP) infections, are distributed globally, and lead to several outbreaks with high pathogenicity and mortality in immunocompetent individuals. This is usually characterized by a rapidly metastatic spread resulting in multiple pyogenic tissue abscesses. To date, even though the explanation of hypervirulent factors of hvKP has been identified, it still remains to be fully understood. The most common key virulence agents of hvKP included (1) siderophore systems for iron acquisition, (2) increased capsule production, (3) the colibactin toxin, (4) hypermucoviscosity, and so on. Several hypervirulence factors have been renewed, and the evolution of MDR-hvKP has been deeply explored recently. We aim to describe a chain of key virulence agents attributed to the lethality of hvKP and MDR-hvKP. In this review, recent advances in renewed factors in hypervirulence were summarized, and potential therapeutic targets are explored. Novel co-existence of hypervirulence agents and multidrug-resistant elements, even the superplasmid, was screened. Superplasmid simultaneously harbours hypervirulence and multidrug-resistant genes and can mobile autonomously by its complete conjugative elements. Research into related immunity has also gained traction, which may cause multiple invasive infections with higher mortality rates than classical ones, such as neutrophil- and complement-mediated activity. The evolution of virulence and multidrug resistance is accelerating. More reliable methods for identifying hvKP or MDR-hvKP must be investigated. Furthermore, it is critical to investigate innovative treatment targets in the future.Keywords: Klebsiella pneumoniae, hypervirulence, multidrug resistant |
| first_indexed | 2024-03-12T15:01:25Z |
| format | Article |
| id | doaj.art-502691a1aa7e43f49a81374712d4dc67 |
| institution | Directory Open Access Journal |
| issn | 1178-6973 |
| language | English |
| last_indexed | 2024-03-12T15:01:25Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj.art-502691a1aa7e43f49a81374712d4dc672023-08-13T22:16:47ZengDove Medical PressInfection and Drug Resistance1178-69732023-08-01Volume 165243524985852Hypervirulent Klebsiella pneumoniaeChen JZhang HLiao XJunjun Chen,1,2 Huan Zhang,1,3 Xuelian Liao1,2 1Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, People’s Republic of China; 2Department of Critical Care Medicine, West China Tianfu Hospital of Sichuan University, Chengdu, People’s Republic of China; 3Department of Cardiac Vascular Surgery Critical Care Medicine, The Third People’s Hospital of Chengdu, Chengdu, People’s Republic of ChinaCorrespondence: Xuelian Liao, Department of Critical Care Medicine, West China Hospital, Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, People’s Republic of China, Tel +8613541023033, Email xuelianliao@hotmail.comAbstract: Hypervirulent Klebsiella pneumoniae (hvKP), especially multidrug-resistant hvKP (MDR-hvKP) infections, are distributed globally, and lead to several outbreaks with high pathogenicity and mortality in immunocompetent individuals. This is usually characterized by a rapidly metastatic spread resulting in multiple pyogenic tissue abscesses. To date, even though the explanation of hypervirulent factors of hvKP has been identified, it still remains to be fully understood. The most common key virulence agents of hvKP included (1) siderophore systems for iron acquisition, (2) increased capsule production, (3) the colibactin toxin, (4) hypermucoviscosity, and so on. Several hypervirulence factors have been renewed, and the evolution of MDR-hvKP has been deeply explored recently. We aim to describe a chain of key virulence agents attributed to the lethality of hvKP and MDR-hvKP. In this review, recent advances in renewed factors in hypervirulence were summarized, and potential therapeutic targets are explored. Novel co-existence of hypervirulence agents and multidrug-resistant elements, even the superplasmid, was screened. Superplasmid simultaneously harbours hypervirulence and multidrug-resistant genes and can mobile autonomously by its complete conjugative elements. Research into related immunity has also gained traction, which may cause multiple invasive infections with higher mortality rates than classical ones, such as neutrophil- and complement-mediated activity. The evolution of virulence and multidrug resistance is accelerating. More reliable methods for identifying hvKP or MDR-hvKP must be investigated. Furthermore, it is critical to investigate innovative treatment targets in the future.Keywords: Klebsiella pneumoniae, hypervirulence, multidrug resistanthttps://www.dovepress.com/hypervirulent-klebsiella-pneumoniae-peer-reviewed-fulltext-article-IDRklebsiella pneumoniaehypervirulencemutidrug resistant. |
| spellingShingle | Chen J Zhang H Liao X Hypervirulent Klebsiella pneumoniae Infection and Drug Resistance klebsiella pneumoniae hypervirulence mutidrug resistant. |
| title | Hypervirulent Klebsiella pneumoniae |
| title_full | Hypervirulent Klebsiella pneumoniae |
| title_fullStr | Hypervirulent Klebsiella pneumoniae |
| title_full_unstemmed | Hypervirulent Klebsiella pneumoniae |
| title_short | Hypervirulent Klebsiella pneumoniae |
| title_sort | hypervirulent klebsiella pneumoniae |
| topic | klebsiella pneumoniae hypervirulence mutidrug resistant. |
| url | https://www.dovepress.com/hypervirulent-klebsiella-pneumoniae-peer-reviewed-fulltext-article-IDR |
| work_keys_str_mv | AT chenj hypervirulentklebsiellapneumoniae AT zhangh hypervirulentklebsiellapneumoniae AT liaox hypervirulentklebsiellapneumoniae |