Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea?
Background: Data from epidemiological studies and randomized clinical trials strongly suggest that obstructive sleep apnea (OSA) is associated with elevated risk of cardiovascular events. Although OSA and cardiovascular diseases share many risk factors, studies have demonstrated that OSA is an indep...
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-10-01
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| Series: | Egyptian Journal of Chest Disease and Tuberculosis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0422763815301096 |
| _version_ | 1818827894720299008 |
|---|---|
| author | Mohamed Amin |
| author_facet | Mohamed Amin |
| author_sort | Mohamed Amin |
| collection | DOAJ |
| description | Background: Data from epidemiological studies and randomized clinical trials strongly suggest that obstructive sleep apnea (OSA) is associated with elevated risk of cardiovascular events. Although OSA and cardiovascular diseases share many risk factors, studies have demonstrated that OSA is an independent risk factor of arterial hypertension and atherosclerosis.
Objective: To determine the impact of treatment with continuous positive airway pressure (CPAP) on carotid artery intima-media thickness (CIMT) in patients with OSA.
Methods: 40 newly diagnosed OSA patients were assigned into two groups. Conservative treatment group (CT, n = 20) which refused CPAP treatment, and CPAP group (CPAP, n = 20) which received CPAP treatment. CIMT was determined at baseline and after 6 months.
Results: Mean follow-up time was 6.1 ± 2.1 months. At baseline, all measurements were similar in both groups and did not change significantly in CT group after 6 months. In contrast, a significant change occurred in CIMT in CPAP group (8 (20) vs. −115 (10) μm, p = 0.03) from baseline.
Conclusion: CPAP significantly reduced CIMT in OSA patients. |
| first_indexed | 2024-12-19T00:50:49Z |
| format | Article |
| id | doaj.art-50272277233844f6889c7bae8aab07c3 |
| institution | Directory Open Access Journal |
| issn | 0422-7638 |
| language | English |
| last_indexed | 2024-12-19T00:50:49Z |
| publishDate | 2016-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Egyptian Journal of Chest Disease and Tuberculosis |
| spelling | doaj.art-50272277233844f6889c7bae8aab07c32022-12-21T20:44:05ZengWolters Kluwer Medknow PublicationsEgyptian Journal of Chest Disease and Tuberculosis0422-76382016-10-0165476576910.1016/j.ejcdt.2016.03.002Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea?Mohamed AminBackground: Data from epidemiological studies and randomized clinical trials strongly suggest that obstructive sleep apnea (OSA) is associated with elevated risk of cardiovascular events. Although OSA and cardiovascular diseases share many risk factors, studies have demonstrated that OSA is an independent risk factor of arterial hypertension and atherosclerosis. Objective: To determine the impact of treatment with continuous positive airway pressure (CPAP) on carotid artery intima-media thickness (CIMT) in patients with OSA. Methods: 40 newly diagnosed OSA patients were assigned into two groups. Conservative treatment group (CT, n = 20) which refused CPAP treatment, and CPAP group (CPAP, n = 20) which received CPAP treatment. CIMT was determined at baseline and after 6 months. Results: Mean follow-up time was 6.1 ± 2.1 months. At baseline, all measurements were similar in both groups and did not change significantly in CT group after 6 months. In contrast, a significant change occurred in CIMT in CPAP group (8 (20) vs. −115 (10) μm, p = 0.03) from baseline. Conclusion: CPAP significantly reduced CIMT in OSA patients.http://www.sciencedirect.com/science/article/pii/S0422763815301096Continuous positive airway pressureObstructive sleep apneaCPAPOSAAtherosclerosisCarotid |
| spellingShingle | Mohamed Amin Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea? Egyptian Journal of Chest Disease and Tuberculosis Continuous positive airway pressure Obstructive sleep apnea CPAP OSA Atherosclerosis Carotid |
| title | Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea? |
| title_full | Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea? |
| title_fullStr | Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea? |
| title_full_unstemmed | Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea? |
| title_short | Can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea? |
| title_sort | can continuous positive air way pressure reverse carotid artery atherosclerosis in obstructive sleep apnea |
| topic | Continuous positive airway pressure Obstructive sleep apnea CPAP OSA Atherosclerosis Carotid |
| url | http://www.sciencedirect.com/science/article/pii/S0422763815301096 |
| work_keys_str_mv | AT mohamedamin cancontinuouspositiveairwaypressurereversecarotidarteryatherosclerosisinobstructivesleepapnea |