Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
It has been suggested that cytokine-mediated inflammation plays a key role for the onset and/or development of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). However, clinical studies have yielded inconsisten...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2018-09-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2018.02122/full |
| _version_ | 1819101024555630592 |
|---|---|
| author | Xi Chen Yang Hu Zongze Cao Qingshan Liu Yong Cheng |
| author_facet | Xi Chen Yang Hu Zongze Cao Qingshan Liu Yong Cheng |
| author_sort | Xi Chen |
| collection | DOAJ |
| description | It has been suggested that cytokine-mediated inflammation plays a key role for the onset and/or development of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). However, clinical studies have yielded inconsistent results for the aberrant cytokine levels in circulation of patients with AD, PD, and ALS. Previous studies have used meta-analysis to address the inconsistent data for blood cytokine levels in the patients with AD, PD, and ALS. Here, we performed a systemic review of cerebrospinal fluid inflammatory cytokine data in patients with AD, PD and ALS, and sought to quantitatively summarize the CSF inflammatory cytokine data with a meta-analytical technique. The systematic search from Pubmed and Web of Science identified 71 articles with 2629 patients and 2049 controls for the meta-analysis. Random-effects meta-analysis demonstrated that CSF TGF-β, MCP-1, and YKL-40 levels were significantly elevated in AD patients when compared with controls. In addition, patients with PD had heightened levels of TGF-β1, IL-6, and IL-1β in CSF. Furthermore, G-CSF, IL-2, IL-15, IL-17, MCP-1, MIP-1α, TNF-α, and VEGF levels were significantly increased in patients with ALS as compared with controls. Taken together, these results not only strengthen the clinical evidence that neurodegenerative diseases are accompanied by the increased inflammatory response, but also reveal the unique inflammatory response profile in the central nervous system of patients with AD, PD and ALS. Given the robust associations between some cytokines and neurodegenerative diseases found in this meta-analysis, CSF inflammatory cytokines may be used as biomarkers for these diseases in the future. |
| first_indexed | 2024-12-22T01:12:06Z |
| format | Article |
| id | doaj.art-5027c400b7cb4e40abb0942be6ffb40f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-22T01:12:06Z |
| publishDate | 2018-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-5027c400b7cb4e40abb0942be6ffb40f2022-12-21T18:43:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-09-01910.3389/fimmu.2018.02122410228Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-AnalysisXi ChenYang HuZongze CaoQingshan LiuYong ChengIt has been suggested that cytokine-mediated inflammation plays a key role for the onset and/or development of neurodegenerative diseases including Alzheimer's disease (AD), Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). However, clinical studies have yielded inconsistent results for the aberrant cytokine levels in circulation of patients with AD, PD, and ALS. Previous studies have used meta-analysis to address the inconsistent data for blood cytokine levels in the patients with AD, PD, and ALS. Here, we performed a systemic review of cerebrospinal fluid inflammatory cytokine data in patients with AD, PD and ALS, and sought to quantitatively summarize the CSF inflammatory cytokine data with a meta-analytical technique. The systematic search from Pubmed and Web of Science identified 71 articles with 2629 patients and 2049 controls for the meta-analysis. Random-effects meta-analysis demonstrated that CSF TGF-β, MCP-1, and YKL-40 levels were significantly elevated in AD patients when compared with controls. In addition, patients with PD had heightened levels of TGF-β1, IL-6, and IL-1β in CSF. Furthermore, G-CSF, IL-2, IL-15, IL-17, MCP-1, MIP-1α, TNF-α, and VEGF levels were significantly increased in patients with ALS as compared with controls. Taken together, these results not only strengthen the clinical evidence that neurodegenerative diseases are accompanied by the increased inflammatory response, but also reveal the unique inflammatory response profile in the central nervous system of patients with AD, PD and ALS. Given the robust associations between some cytokines and neurodegenerative diseases found in this meta-analysis, CSF inflammatory cytokines may be used as biomarkers for these diseases in the future.https://www.frontiersin.org/article/10.3389/fimmu.2018.02122/fullinflammationcytokineneurodegenerative diseasescerebrospinal fluidmeta-analysis |
| spellingShingle | Xi Chen Yang Hu Zongze Cao Qingshan Liu Yong Cheng Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis Frontiers in Immunology inflammation cytokine neurodegenerative diseases cerebrospinal fluid meta-analysis |
| title | Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis |
| title_full | Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis |
| title_fullStr | Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis |
| title_short | Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis |
| title_sort | cerebrospinal fluid inflammatory cytokine aberrations in alzheimer s disease parkinson s disease and amyotrophic lateral sclerosis a systematic review and meta analysis |
| topic | inflammation cytokine neurodegenerative diseases cerebrospinal fluid meta-analysis |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2018.02122/full |
| work_keys_str_mv | AT xichen cerebrospinalfluidinflammatorycytokineaberrationsinalzheimersdiseaseparkinsonsdiseaseandamyotrophiclateralsclerosisasystematicreviewandmetaanalysis AT yanghu cerebrospinalfluidinflammatorycytokineaberrationsinalzheimersdiseaseparkinsonsdiseaseandamyotrophiclateralsclerosisasystematicreviewandmetaanalysis AT zongzecao cerebrospinalfluidinflammatorycytokineaberrationsinalzheimersdiseaseparkinsonsdiseaseandamyotrophiclateralsclerosisasystematicreviewandmetaanalysis AT qingshanliu cerebrospinalfluidinflammatorycytokineaberrationsinalzheimersdiseaseparkinsonsdiseaseandamyotrophiclateralsclerosisasystematicreviewandmetaanalysis AT yongcheng cerebrospinalfluidinflammatorycytokineaberrationsinalzheimersdiseaseparkinsonsdiseaseandamyotrophiclateralsclerosisasystematicreviewandmetaanalysis |