Comparative Study of the Mode of Action of Clinically Approved Platinum-Based Chemotherapeutics

Comparative Study of the Mode of Action of Clinically Approved Platinum-Based Chemotherapeutics

Platinum drugs are among the most effective anticancer agents, but their mode of action is still not fully understood. We therefore carried out a systematic investigation on the cellular activities of cisplatin, carboplatin and oxaliplatin in A498 kidney cancer cells. Cytotoxicity was higher for cis...

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Bibliographic Details
Main Authors: Sarah Schoch, Sabine Gajewski, Jana Rothfuß, Andrea Hartwig, Beate Köberle
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
cisplatin analogues
tumor cells
gene expression profiling
DNA damage response
Online Access:https://www.mdpi.com/1422-0067/21/18/6928

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