More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing
Abstract Background During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-08-01
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| Series: | Journal of Nanobiotechnology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12951-021-00973-7 |
| _version_ | 1798026428483108864 |
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| author | Qianmin Ou Shaohan Zhang Chuanqiang Fu Le Yu Peikun Xin Zhipeng Gu Zeyuan Cao Jun Wu Yan Wang |
| author_facet | Qianmin Ou Shaohan Zhang Chuanqiang Fu Le Yu Peikun Xin Zhipeng Gu Zeyuan Cao Jun Wu Yan Wang |
| author_sort | Qianmin Ou |
| collection | DOAJ |
| description | Abstract Background During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. Results Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. Conclusion Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. Graphic Abstract |
| first_indexed | 2024-04-11T18:35:21Z |
| format | Article |
| id | doaj.art-502b3cebf5fc4dd0974b5b744f795449 |
| institution | Directory Open Access Journal |
| issn | 1477-3155 |
| language | English |
| last_indexed | 2024-04-11T18:35:21Z |
| publishDate | 2021-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Nanobiotechnology |
| spelling | doaj.art-502b3cebf5fc4dd0974b5b744f7954492022-12-22T04:09:17ZengBMCJournal of Nanobiotechnology1477-31552021-08-0119111210.1186/s12951-021-00973-7More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healingQianmin Ou0Shaohan Zhang1Chuanqiang Fu2Le Yu3Peikun Xin4Zhipeng Gu5Zeyuan Cao6Jun Wu7Yan Wang8Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of StomatologySchool of Biomedical Engineering, Sun Yat-Sen UniversityHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of StomatologyHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of StomatologySchool of Biomedical Engineering, Sun Yat-Sen UniversityCollege of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan UniversityHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of StomatologySchool of Biomedical Engineering, Sun Yat-Sen UniversityHospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of StomatologyAbstract Background During wound healing, the overproduction of reactive oxygen species (ROS) can break the cellular oxidant/antioxidant balance, which prolongs healing. The wound dressings targeting the mitigation of ROS will be of great advantages for the wound healing. puerarin (PUE) and ferulic acid (FA) are natural compounds derived from herbs that exhibit multiple pharmacological activities, such as antioxidant and anti-inflammatory effects. Polydopamine (PDA) is made from natural dopamine and shows excellent antioxidant function. Therefore, the combination of natural antioxidants into hydrogel dressing is a promising therapy for wound healing. Results Hydrogel wound dressings have been developed by incorporating PUE or FA via PDA nanoparticles (NPs) into polyethylene glycol diacrylate (PEG-DA) hydrogel. This hydrogel can load natural antioxidant drugs and retain the drug in the gel network for a long period due to the presence of PDA NPs. Under oxidative stress, this hydrogel can improve the activity of superoxide dismutase and glutathione peroxidase and reduce the levels of ROS and malondialdehyde, thus preventing oxidative damage to cells, and then promoting wound healing, tissue regeneration, and collagen accumulation. Conclusion Overall, this triple antioxidant hydrogel accelerates wound healing by alleviating oxidative injury. Our study thus provides a new way about co-delivery of multiple antioxidant natural molecules from herbs via antioxidant nanoparticles for wound healing and skin regeneration. Graphic Abstracthttps://doi.org/10.1186/s12951-021-00973-7PuerarinFerulic acidPolydopamineHydrogelWound healing |
| spellingShingle | Qianmin Ou Shaohan Zhang Chuanqiang Fu Le Yu Peikun Xin Zhipeng Gu Zeyuan Cao Jun Wu Yan Wang More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing Journal of Nanobiotechnology Puerarin Ferulic acid Polydopamine Hydrogel Wound healing |
| title | More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing |
| title_full | More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing |
| title_fullStr | More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing |
| title_full_unstemmed | More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing |
| title_short | More natural more better: triple natural anti-oxidant puerarin/ferulic acid/polydopamine incorporated hydrogel for wound healing |
| title_sort | more natural more better triple natural anti oxidant puerarin ferulic acid polydopamine incorporated hydrogel for wound healing |
| topic | Puerarin Ferulic acid Polydopamine Hydrogel Wound healing |
| url | https://doi.org/10.1186/s12951-021-00973-7 |
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