Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in rats
The endocannabinoid system modulates many brain functions, including episodic memories, which contain memories of time and places. Most studies have focused on the involvement of the endocannabinoid system in spatial memory; however, its role in temporal memory is not well understood. Few studies ha...
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| Format: | Article |
| Language: | English |
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IMR Press
2020-03-01
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| Series: | Journal of Integrative Neuroscience |
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| Online Access: | https://jin.imrpress.com/fileup/1757-448X/PDF/1585708658698-1461019163.pdf |
| _version_ | 1818149736116387840 |
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| author | Ko-En Chiang, Yi-Tse Hsiao |
| author_facet | Ko-En Chiang, Yi-Tse Hsiao |
| author_sort | Ko-En Chiang, Yi-Tse Hsiao |
| collection | DOAJ |
| description | The endocannabinoid system modulates many brain functions, including episodic memories, which contain memories of time and places. Most studies have focused on the involvement of the endocannabinoid system in spatial memory; however, its role in temporal memory is not well understood. Few studies have tested whether the unilateral endocannabinoid system is sufficient to modulate memory retrieval. Here, we tested whether type 1 cannabinoid receptors in the right hippocampal cornu ammonis area 1 region are enough to modulate the retrieval of episodic memories, specifically their spatial and temporal components. Because rats have innate preferences for displaced or old familiar objects, we changed the locations of "old familiar" and "recent familiar" objects in an open field and measured the rats' exploration times to evaluate spatial and temporal memory. To address the influence of the type 1 cannabinoid receptors on the retrieval of episodic-like memories, two doses of arachidonylcyclopropylamide, a selective type 1 cannabinoid receptor agonist, were infused into the cornu ammonis area 1 of rats ten minutes before the discrimination trials. We observed that rats injected with a low dose of arachidonylcyclopropylamide spent less time investigating displaced objects, suggesting spatial memory impairment, whereas those receiving a high dose explored old familiar objects less frequently, suggesting temporal memory impairment. This indicates that unilateral activation of type 1 cannabinoid receptors in the cornu ammonis area 1 impairs the spatial and temporal aspects of episodic memories. This research mimics the influence of marijuana intoxication effects in humans, such as spatial and temporal disintegration. |
| first_indexed | 2024-12-11T13:11:46Z |
| format | Article |
| id | doaj.art-502d4910367c46d4991b5ff16674df3e |
| institution | Directory Open Access Journal |
| issn | 1757-448X |
| language | English |
| last_indexed | 2024-12-11T13:11:46Z |
| publishDate | 2020-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-502d4910367c46d4991b5ff16674df3e2022-12-22T01:06:09ZengIMR PressJournal of Integrative Neuroscience1757-448X2020-03-01191111910.31083/j.jin.2020.01.1190Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in ratsKo-En Chiang, Yi-Tse Hsiao01 Department of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, Taipei, 10617, TaiwanThe endocannabinoid system modulates many brain functions, including episodic memories, which contain memories of time and places. Most studies have focused on the involvement of the endocannabinoid system in spatial memory; however, its role in temporal memory is not well understood. Few studies have tested whether the unilateral endocannabinoid system is sufficient to modulate memory retrieval. Here, we tested whether type 1 cannabinoid receptors in the right hippocampal cornu ammonis area 1 region are enough to modulate the retrieval of episodic memories, specifically their spatial and temporal components. Because rats have innate preferences for displaced or old familiar objects, we changed the locations of "old familiar" and "recent familiar" objects in an open field and measured the rats' exploration times to evaluate spatial and temporal memory. To address the influence of the type 1 cannabinoid receptors on the retrieval of episodic-like memories, two doses of arachidonylcyclopropylamide, a selective type 1 cannabinoid receptor agonist, were infused into the cornu ammonis area 1 of rats ten minutes before the discrimination trials. We observed that rats injected with a low dose of arachidonylcyclopropylamide spent less time investigating displaced objects, suggesting spatial memory impairment, whereas those receiving a high dose explored old familiar objects less frequently, suggesting temporal memory impairment. This indicates that unilateral activation of type 1 cannabinoid receptors in the cornu ammonis area 1 impairs the spatial and temporal aspects of episodic memories. This research mimics the influence of marijuana intoxication effects in humans, such as spatial and temporal disintegration.https://jin.imrpress.com/fileup/1757-448X/PDF/1585708658698-1461019163.pdf|endocannabinoid system|marijuana intoxication|ca1 hippocampus|episodic memory|temporal disintegration|spatial memory |
| spellingShingle | Ko-En Chiang, Yi-Tse Hsiao Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in rats Journal of Integrative Neuroscience |endocannabinoid system|marijuana intoxication|ca1 hippocampus|episodic memory|temporal disintegration|spatial memory |
| title | Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in rats |
| title_full | Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in rats |
| title_fullStr | Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in rats |
| title_full_unstemmed | Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in rats |
| title_short | Activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic-like memories in rats |
| title_sort | activation of cannabinoid receptor type 1 impairs spatial and temporal aspects of episodic like memories in rats |
| topic | |endocannabinoid system|marijuana intoxication|ca1 hippocampus|episodic memory|temporal disintegration|spatial memory |
| url | https://jin.imrpress.com/fileup/1757-448X/PDF/1585708658698-1461019163.pdf |
| work_keys_str_mv | AT koenchiangyitsehsiao activationofcannabinoidreceptortype1impairsspatialandtemporalaspectsofepisodiclikememoriesinrats |