Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome
Background: Diabetes mellitus is a well known risk factor for acute coronary syndrome but the hypothesis that patients with acute phase hyperglycemia, regardless the previous diagnosis of diabetes, have worse prognosis than those with normal glucose values is controversial. This paper aims to estima...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2010-10-01
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| Series: | مجلة كلية الطب |
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| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/967 |
| _version_ | 1827392817941446656 |
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| author | Ameer A. Oraha Salim M. AL Ruba'ae |
| author_facet | Ameer A. Oraha Salim M. AL Ruba'ae |
| author_sort | Ameer A. Oraha |
| collection | DOAJ |
| description | Background: Diabetes mellitus is a well known risk factor for acute coronary syndrome but the hypothesis that patients with acute phase hyperglycemia, regardless the previous diagnosis of diabetes, have worse prognosis than those with normal glucose values is controversial. This paper aims to estimate the prevalence of admission hyperglycemia, its effect on in-hospital prognosis of diabetic and non-diabetic patients with acute coronary syndrome, and to compare it with 2nd day fasting plasma glucose as a prognostic marker.
Methods: One hundred patients, (59) diabetic and (41) non-diabetic, with documented acute coronary syndrome enrolled in this study over the period of June/ 2009-Jan./2010 from coronary care unit of Baghdad Teaching Hospital, who were thoroughly examined, hyperglycemia documented on admission and next day, then followed up daily during hospitalization for development of complications or death.
Results: Heart failure and recurrent cardiac ischemic events were significantly more common in diabetic than non-diabetic patients (P-value:0.04 for both),while arrhythmias, cardiogenic shock and mortality rate were not significantly different between both study groups. Admission hyperglycemia more than 200mg/dl was associated with higher incidence of cardiogenic
shock, recurrent ischemic events, heart failure, and death in non-diabetic patients (P-value 0.009, 0.022, 0.025, 0.026 respectively) but no more arrhythmias, and in diabetic patients admission hyperglycemia was only associated with more recurrent ischemic events (P-value 0.017). Second day fasting plasma glucose more than 126mg/dl was associated with higher incidence of heart failure in non-diabetic patients and more recurrent ischemic events in both study groups.
Conclusion: Admission hyperglycemia is a poor in-hospital prognostic marker in non-diabetic & to lesser extend in diabetic patients suffering acute coronary syndrome. |
| first_indexed | 2024-03-08T17:38:51Z |
| format | Article |
| id | doaj.art-502e35eabb6e40a8b34252afbde7082a |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:38:51Z |
| publishDate | 2010-10-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-502e35eabb6e40a8b34252afbde7082a2024-01-02T11:30:20ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572010-10-0152310.32007/jfacmedbagdad.v3250-254%Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndromeAmeer A. Oraha0Salim M. AL Ruba'ae1Dept. of Medicine, College of Medicine, University of Baghdad.Dept. of Medicine, College of Medicine, University of Baghdad.Background: Diabetes mellitus is a well known risk factor for acute coronary syndrome but the hypothesis that patients with acute phase hyperglycemia, regardless the previous diagnosis of diabetes, have worse prognosis than those with normal glucose values is controversial. This paper aims to estimate the prevalence of admission hyperglycemia, its effect on in-hospital prognosis of diabetic and non-diabetic patients with acute coronary syndrome, and to compare it with 2nd day fasting plasma glucose as a prognostic marker. Methods: One hundred patients, (59) diabetic and (41) non-diabetic, with documented acute coronary syndrome enrolled in this study over the period of June/ 2009-Jan./2010 from coronary care unit of Baghdad Teaching Hospital, who were thoroughly examined, hyperglycemia documented on admission and next day, then followed up daily during hospitalization for development of complications or death. Results: Heart failure and recurrent cardiac ischemic events were significantly more common in diabetic than non-diabetic patients (P-value:0.04 for both),while arrhythmias, cardiogenic shock and mortality rate were not significantly different between both study groups. Admission hyperglycemia more than 200mg/dl was associated with higher incidence of cardiogenic shock, recurrent ischemic events, heart failure, and death in non-diabetic patients (P-value 0.009, 0.022, 0.025, 0.026 respectively) but no more arrhythmias, and in diabetic patients admission hyperglycemia was only associated with more recurrent ischemic events (P-value 0.017). Second day fasting plasma glucose more than 126mg/dl was associated with higher incidence of heart failure in non-diabetic patients and more recurrent ischemic events in both study groups. Conclusion: Admission hyperglycemia is a poor in-hospital prognostic marker in non-diabetic & to lesser extend in diabetic patients suffering acute coronary syndrome.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/967admission hyperglycemia, acute coronary syndrome, diabetes mellitus, mortality, morbidity. |
| spellingShingle | Ameer A. Oraha Salim M. AL Ruba'ae Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome مجلة كلية الطب admission hyperglycemia, acute coronary syndrome, diabetes mellitus, mortality, morbidity. |
| title | Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome |
| title_full | Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome |
| title_fullStr | Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome |
| title_full_unstemmed | Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome |
| title_short | Prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome |
| title_sort | prognostic implications of admission hyperglycemia for inhospital morbidity and mortality in acute coronary syndrome |
| topic | admission hyperglycemia, acute coronary syndrome, diabetes mellitus, mortality, morbidity. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/967 |
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