Modern conceptions of an uric acid role in development of essential hypertension
The article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentr...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
"Consilium Medicum" Publishing house
2011-08-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30889 |
| _version_ | 1818326562956640256 |
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| author | Ol'ga Vasil'evna Polovitkina Elena Vladimirovna Oshchepkova Viktor Aleksandrovich Dmitriev Vladimir Nikolaevich Titov O V Polovitkina E V Oschepkova V A Dmitriev V N Titov |
| author_facet | Ol'ga Vasil'evna Polovitkina Elena Vladimirovna Oshchepkova Viktor Aleksandrovich Dmitriev Vladimir Nikolaevich Titov O V Polovitkina E V Oschepkova V A Dmitriev V N Titov |
| author_sort | Ol'ga Vasil'evna Polovitkina |
| collection | DOAJ |
| description | The article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentrations of UA in hypertensive patients. Experimental evidence suggests UA involvement in the processes of nonspecific inflammation, oxidant stress, endothelial dysfunction. It is shown that elevated UA levels in blood serum lead to affection of target organs. |
| first_indexed | 2024-12-13T12:02:21Z |
| format | Article |
| id | doaj.art-50312464fdcd438eb2d5d312e7e72c8b |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-13T12:02:21Z |
| publishDate | 2011-08-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-50312464fdcd438eb2d5d312e7e72c8b2022-12-21T23:47:03Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422011-08-01838384127905Modern conceptions of an uric acid role in development of essential hypertensionOl'ga Vasil'evna PolovitkinaElena Vladimirovna OshchepkovaViktor Aleksandrovich DmitrievVladimir Nikolaevich TitovO V Polovitkina0E V Oschepkova1V A Dmitriev2V N Titov3Russian Research Cardiological Center, MoscowRussian Research Cardiological Center, MoscowRussian Research Cardiological Center, MoscowRussian Research Cardiological Center, MoscowThe article deals with current studies on the role of uric acid (UA) in development of cardiovascular diseases. The results of large prospective trials are presented which have revealed a pathogenetic role of UA in development of essential hypertension. Clinical trials demonstrated elevated concentrations of UA in hypertensive patients. Experimental evidence suggests UA involvement in the processes of nonspecific inflammation, oxidant stress, endothelial dysfunction. It is shown that elevated UA levels in blood serum lead to affection of target organs.https://ter-arkhiv.ru/0040-3660/article/view/30889essential hypertensionblood serum uric acidurinary uric acidnonspecific inflammationendothelial dysfunction |
| spellingShingle | Ol'ga Vasil'evna Polovitkina Elena Vladimirovna Oshchepkova Viktor Aleksandrovich Dmitriev Vladimir Nikolaevich Titov O V Polovitkina E V Oschepkova V A Dmitriev V N Titov Modern conceptions of an uric acid role in development of essential hypertension Терапевтический архив essential hypertension blood serum uric acid urinary uric acid nonspecific inflammation endothelial dysfunction |
| title | Modern conceptions of an uric acid role in development of essential hypertension |
| title_full | Modern conceptions of an uric acid role in development of essential hypertension |
| title_fullStr | Modern conceptions of an uric acid role in development of essential hypertension |
| title_full_unstemmed | Modern conceptions of an uric acid role in development of essential hypertension |
| title_short | Modern conceptions of an uric acid role in development of essential hypertension |
| title_sort | modern conceptions of an uric acid role in development of essential hypertension |
| topic | essential hypertension blood serum uric acid urinary uric acid nonspecific inflammation endothelial dysfunction |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30889 |
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