Homoarginine Supplementation Prevents Left Ventricular Dilatation and Preserves Systolic Function in a Model of Coronary Artery Disease

Homoarginine Supplementation Prevents Left Ventricular Dilatation and Preserves Systolic Function in a Model of Coronary Artery Disease

Background Homoarginine (hArg) has been shown to be cardioprotective in a model of ischemic heart failure; however, the mechanism remains unknown. hArg can inhibit tissue‐nonspecific alkaline phosphatase (TNAP), an enzyme that promotes vascular calcification. We hypothesized that hArg will exert ben...

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Bibliographic Details
Main Authors: Roman N. Rodionov, Hoshimjon Begmatov, Natalia Jarzebska, Ketul Patel, Matthew T. Mills, Zulaikha Ghani, Doreen Khakshour, Pankti Tamboli, Mitul N. Patel, Mirette Abdalla, Maryann Assaf, Stefan R. Bornstein, Jose Luis Millan, Stefanie M. Bode‐Böger, Jens Martens‐Lobenhoffer, Norbert Weiss, Olga V. Savinova
Format: Article
Language:English
Published: Wiley 2019-07-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac remodeling
coronary artery disease
coronary calcium
homoarginine
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.119.012486

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