Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance
In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector. Although several cellular, molecular, and gene...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Journal of Infection and Public Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S187603412200363X |
| _version_ | 1797954162790498304 |
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| author | Ali A. Rabaan Khalid Eljaaly Wadha A. Alfouzan Abbas Al Mutair Saad Alhumaid Amal H. Alfaraj Yahya Aldawood Abdulmonem A. Alsaleh Hawra Albayat Reyouf Al Azmi Nawal AlKaabi Samira J. Alzahrani Salma AlBahrani Tarek Sulaiman Abeer N. Alshukairi Abdulmonem A. Abuzaid Mohammed Garout Rafiq Ahmad Javed Muhammad |
| author_facet | Ali A. Rabaan Khalid Eljaaly Wadha A. Alfouzan Abbas Al Mutair Saad Alhumaid Amal H. Alfaraj Yahya Aldawood Abdulmonem A. Alsaleh Hawra Albayat Reyouf Al Azmi Nawal AlKaabi Samira J. Alzahrani Salma AlBahrani Tarek Sulaiman Abeer N. Alshukairi Abdulmonem A. Abuzaid Mohammed Garout Rafiq Ahmad Javed Muhammad |
| author_sort | Ali A. Rabaan |
| collection | DOAJ |
| description | In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector. Although several cellular, molecular, and genetic mechanisms have been proposed to explain the drug resistance mechanism in fungi, but a complete understanding of the molecular and genetic mechanisms is still lacking. Besides the genetic mechanism, epigenetic mechanisms are pivotal in the fungal lifecycle and disease biology. However, very little is understood about the role of epigenetic mechanisms in the emergence of multi-drug resistance in fungi, especially in Candida auris (C. auris). The current narrative review summaries the clinical characteristics, genomic organization, and molecular/genetic/epigenetic mechanisms underlying the emergence of drug resistance in C. auris. A very few studies have attempted to evaluate the role of epigenetic mechanisms in C. auris. Furthermore, advanced genetic tools such as the CRISP-Cas9 system can be utilized to elucidate the epigenetic mechanisms and their role in the emergence of multi-drug resistance in C. auris. |
| first_indexed | 2024-04-10T23:13:16Z |
| format | Article |
| id | doaj.art-5034d7f2bed742889707ddf34cec5cb3 |
| institution | Directory Open Access Journal |
| issn | 1876-0341 |
| language | English |
| last_indexed | 2024-04-10T23:13:16Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Infection and Public Health |
| spelling | doaj.art-5034d7f2bed742889707ddf34cec5cb32023-01-13T04:15:58ZengElsevierJournal of Infection and Public Health1876-03412023-02-01162257263Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistanceAli A. Rabaan0Khalid Eljaaly1Wadha A. Alfouzan2Abbas Al Mutair3Saad Alhumaid4Amal H. Alfaraj5Yahya Aldawood6Abdulmonem A. Alsaleh7Hawra Albayat8Reyouf Al Azmi9Nawal AlKaabi10Samira J. Alzahrani11Salma AlBahrani12Tarek Sulaiman13Abeer N. Alshukairi14Abdulmonem A. Abuzaid15Mohammed Garout16Rafiq Ahmad17Javed Muhammad18Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia; College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia; Department of Public Health and Nutrition, The University of Haripur, Haripur 22610, Pakistan; Corresponding author at: Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia.Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Pharmacy Practice and Science Department, College of Pharmacy, University of Arizona, Tucson, AZ, USADepartment of Microbiology, Faculty of Medicine, Kuwait University, Safat 13110, Kuwait; Microbiology Unit, Department of Laboratories, Farwania Hospital, Farwania 85000, KuwaitResearch Center, Almoosa Specialist Hospital, Al-Ahsa 36342, Saudi Arabia; College of Nursing, Princess Norah Bint Abdulrahman University, Riyadh 11564, Saudi Arabia; School of Nursing, Wollongong University, Wollongong, NSW 2522, Australia; Nursing Department, Prince Sultan Military College of Health Sciences, Dhahran 33048, Saudi ArabiaAdministration of Pharmaceutical Care, Al-Ahsa Health Cluster, Ministry of Health, Al-Ahsa 31982, Saudi ArabiaPediatric Department, Abqaiq General Hospital, First Eastern Health Cluster, Abqaiq 33261, Saudi ArabiaClinical Laboratory Science Department, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi ArabiaClinical Laboratory Science Department, Mohammed Al-Mana College for Medical Sciences, Dammam 34222, Saudi ArabiaInfectious Disease Department, King Saud Medical City, Riyadh 7790, Saudi ArabiaInfection Prevention and Control, Eastern Health Cluster, Dammam 32253, Saudi ArabiaSheikh Khalifa Medical City, Abu Dhabi Health Services Company (SEHA), Abu Dhabi, 51900, United Arab Emirates; College of Medicine and Health Science, Khalifa University, Abu Dhabi, 127788, United Arab EmiratesMolecular Diagnostic Laboratory, King Fahd Military Medical Complex, Dhahran 31932, Saudi ArabiaInfectious Disease Unit, Specialty Internal Medicine, King Fahd Military Medical Complex, Dhahran 31932, Saudi ArabiaInfectious Diseases Section, Medical Specialties Department, King Fahad Medical City, Riyadh, Saudi ArabiaCollege of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia; Department of Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi ArabiaMedical Microbiology Department, Security Forces Hospital Programme, Dammam 32314, Saudi ArabiaDepartment of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi ArabiaDepartment of Microbiology, The University of Haripur, Haripur 22610, PakistanDepartment of Microbiology, The University of Haripur, Haripur 22610, Pakistan; Corresponding author.In recent years, we are facing the challenge of drug resistance emergence in fungi. The availability of limited antifungals and development of multi-drug resistance in fungal pathogens has become a serious concern in the past years in the health sector. Although several cellular, molecular, and genetic mechanisms have been proposed to explain the drug resistance mechanism in fungi, but a complete understanding of the molecular and genetic mechanisms is still lacking. Besides the genetic mechanism, epigenetic mechanisms are pivotal in the fungal lifecycle and disease biology. However, very little is understood about the role of epigenetic mechanisms in the emergence of multi-drug resistance in fungi, especially in Candida auris (C. auris). The current narrative review summaries the clinical characteristics, genomic organization, and molecular/genetic/epigenetic mechanisms underlying the emergence of drug resistance in C. auris. A very few studies have attempted to evaluate the role of epigenetic mechanisms in C. auris. Furthermore, advanced genetic tools such as the CRISP-Cas9 system can be utilized to elucidate the epigenetic mechanisms and their role in the emergence of multi-drug resistance in C. auris.http://www.sciencedirect.com/science/article/pii/S187603412200363XDrug resistanceFungiCandida aurisGeneticEpigenetic |
| spellingShingle | Ali A. Rabaan Khalid Eljaaly Wadha A. Alfouzan Abbas Al Mutair Saad Alhumaid Amal H. Alfaraj Yahya Aldawood Abdulmonem A. Alsaleh Hawra Albayat Reyouf Al Azmi Nawal AlKaabi Samira J. Alzahrani Salma AlBahrani Tarek Sulaiman Abeer N. Alshukairi Abdulmonem A. Abuzaid Mohammed Garout Rafiq Ahmad Javed Muhammad Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance Journal of Infection and Public Health Drug resistance Fungi Candida auris Genetic Epigenetic |
| title | Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance |
| title_full | Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance |
| title_fullStr | Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance |
| title_full_unstemmed | Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance |
| title_short | Psychogenetic, genetic and epigenetic mechanisms in Candida auris: Role in drug resistance |
| title_sort | psychogenetic genetic and epigenetic mechanisms in candida auris role in drug resistance |
| topic | Drug resistance Fungi Candida auris Genetic Epigenetic |
| url | http://www.sciencedirect.com/science/article/pii/S187603412200363X |
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