Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates
Inactivation of bacteria under the influence of visible light in presence of nanostructured materials is an alternative approach to overcome the serious problem of the growing resistance of pathogenic bacteria to antibiotics. Cadmium sulfide quantum dots are superefficient photocatalytic material su...
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MDPI AG
2022-06-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/7/1309 |
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| author | Anna Stavitskaya Eliza Sitmukhanova Adeliya Sayfutdinova Elnara Khusnetdenova Kristina Mazurova Kirill Cherednichenko Ekaterina Naumenko Rawil Fakhrullin |
| author_facet | Anna Stavitskaya Eliza Sitmukhanova Adeliya Sayfutdinova Elnara Khusnetdenova Kristina Mazurova Kirill Cherednichenko Ekaterina Naumenko Rawil Fakhrullin |
| author_sort | Anna Stavitskaya |
| collection | DOAJ |
| description | Inactivation of bacteria under the influence of visible light in presence of nanostructured materials is an alternative approach to overcome the serious problem of the growing resistance of pathogenic bacteria to antibiotics. Cadmium sulfide quantum dots are superefficient photocatalytic material suitable for visible light transformation. In this work, CdS nanoparticles with size of less than 10 nm (QDs) were synthesized on the surface of natural and synthetic mesoporous aluminosilicates and silicates (halloysite nanotubes, MCM-41, MCM-41/Halloysite, SBA-15). Materials containing 5–7 wt.% of CdS were characterized and tested as agents for photocatalytic bacteria degradation of Gram-positive <i>S. aureus</i> and Gram-negative <i>E. coli</i> with multiple antibiotic resistance. Eukaryotic cell viability tests were also conducted on the model cancer cells A 459. We found that the carrier affects prokaryotic and eukaryotic toxicity of CdS quantum dots. CdS/MCM-41/HNTs were assumed to be less toxic to eukaryotic cells and possess the most prominent photocatalytic antibacterial efficiency. Under visible light irradiation, it induced 100% bacterial growth inhibition at the concentration of 125 μg/mL and the bacteriostatic effect at the concentration of 63 μg/mL. CdS/MCM-41/HNTs showed 100% <i>E. coli</i> growth inhibition in the concentration of 1000 μg/mL under visible light irradiation. |
| first_indexed | 2024-03-09T06:04:15Z |
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| id | doaj.art-50374e37e4cc42a2ab5919f0d1fa6a73 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T06:04:15Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-50374e37e4cc42a2ab5919f0d1fa6a732023-12-03T12:05:54ZengMDPI AGPharmaceutics1999-49232022-06-01147130910.3390/pharmaceutics14071309Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and SilicatesAnna Stavitskaya0Eliza Sitmukhanova1Adeliya Sayfutdinova2Elnara Khusnetdenova3Kristina Mazurova4Kirill Cherednichenko5Ekaterina Naumenko6Rawil Fakhrullin7Functional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, RussiaFunctional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, RussiaFunctional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, RussiaFunctional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, RussiaFunctional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, RussiaFunctional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, RussiaBionanotechnology Lab, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kreml uramı 18, 420008 Kazan, Republic of Tatarstan, RussiaFunctional Aluminosilicate Nanomaterials Lab, Gubkin University, 119991 Moscow, RussiaInactivation of bacteria under the influence of visible light in presence of nanostructured materials is an alternative approach to overcome the serious problem of the growing resistance of pathogenic bacteria to antibiotics. Cadmium sulfide quantum dots are superefficient photocatalytic material suitable for visible light transformation. In this work, CdS nanoparticles with size of less than 10 nm (QDs) were synthesized on the surface of natural and synthetic mesoporous aluminosilicates and silicates (halloysite nanotubes, MCM-41, MCM-41/Halloysite, SBA-15). Materials containing 5–7 wt.% of CdS were characterized and tested as agents for photocatalytic bacteria degradation of Gram-positive <i>S. aureus</i> and Gram-negative <i>E. coli</i> with multiple antibiotic resistance. Eukaryotic cell viability tests were also conducted on the model cancer cells A 459. We found that the carrier affects prokaryotic and eukaryotic toxicity of CdS quantum dots. CdS/MCM-41/HNTs were assumed to be less toxic to eukaryotic cells and possess the most prominent photocatalytic antibacterial efficiency. Under visible light irradiation, it induced 100% bacterial growth inhibition at the concentration of 125 μg/mL and the bacteriostatic effect at the concentration of 63 μg/mL. CdS/MCM-41/HNTs showed 100% <i>E. coli</i> growth inhibition in the concentration of 1000 μg/mL under visible light irradiation.https://www.mdpi.com/1999-4923/14/7/1309halloysiteMCM-41SBA-15<i>S. aureus</i>visible lightquantum dots |
| spellingShingle | Anna Stavitskaya Eliza Sitmukhanova Adeliya Sayfutdinova Elnara Khusnetdenova Kristina Mazurova Kirill Cherednichenko Ekaterina Naumenko Rawil Fakhrullin Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates Pharmaceutics halloysite MCM-41 SBA-15 <i>S. aureus</i> visible light quantum dots |
| title | Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates |
| title_full | Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates |
| title_fullStr | Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates |
| title_full_unstemmed | Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates |
| title_short | Photoinduced Antibacterial Activity and Cytotoxicity of CdS Stabilized on Mesoporous Aluminosilicates and Silicates |
| title_sort | photoinduced antibacterial activity and cytotoxicity of cds stabilized on mesoporous aluminosilicates and silicates |
| topic | halloysite MCM-41 SBA-15 <i>S. aureus</i> visible light quantum dots |
| url | https://www.mdpi.com/1999-4923/14/7/1309 |
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