Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19
Background. Lipid profile and its related ratios such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio, LDL-C/HDL-C ratio, white blood cell (WBC)/HDL-C ratio, and fasting blood gluc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2023-01-01
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| Series: | Journal of Lipids |
| Online Access: | http://dx.doi.org/10.1155/2023/6329873 |
| _version_ | 1797871503980625920 |
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| author | Jafar Mohammadshahi Hassan Ghobadi Golchin Matinfar Mohammad Hossein Boskabady Mohammad Reza Aslani |
| author_facet | Jafar Mohammadshahi Hassan Ghobadi Golchin Matinfar Mohammad Hossein Boskabady Mohammad Reza Aslani |
| author_sort | Jafar Mohammadshahi |
| collection | DOAJ |
| description | Background. Lipid profile and its related ratios such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio, LDL-C/HDL-C ratio, white blood cell (WBC)/HDL-C ratio, and fasting blood glucose (FBG)/HDL-C ratio are valuable indicators that have been studied in various disorders to predict mortality. The present study was conducted with the aim of investigating the role of lipid profile ratios in predicting mortality in COVID-19 patients. Methods. At the beginning of hospitalization, laboratory tests were taken from all patients (n=300). The ability of lipid profile ratios to determine the COVID-19 severity was evaluated using receiver-operating characteristic (ROC). In addition, survival probability was determined with the average of Kaplan-Meier curves, so that the end point was death. Results. In deceased patients, TG, TC, LDL-C, HDL-C, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C parameters were significantly lower than those of surviving patients, while WBC/HDL-C and FBG/HDL-C were significantly higher. TC (HR=3.178, 95%CI=1.064 to 9.491, P<0.05), TG (HR=3.276, 95%CI=1.111 to 9.655, P<0.05), LDL-C (HR=3.207, 95%CI=1.104 to 9.316, P<0.05), and HDL-C (HR=3.690, 95%CI=1.290 to 10.554, P<0.05), as well as TC/HDL-C (HR=3.860, 95%CI=1.289 to 11.558, P<0.05), TG/HDL-C (HR=3.860, 95%CI=1.289 to 11.558, P<0.05), LDL-C/HDL-C (HR=3.915, 95%CI=1.305 to 11.739, P<0.05), WBC/HDL-C (HR=3.232, 95%CI=1.176 to 8.885, P<0.05), and FBG/HDL-C ratios (HR=4.474, 95%CI=1.567 to 12.777, P<0.01), were detectably related to survival. The multivariate Cox regression models showed that only FBG/HDL-C ratio (HR=5.477, 95%CI=1.488 to 20.153, P<0.01) was significantly related to survival. Conclusion. The results suggested that FBG/HDL-C ratio in hospital-admitted COVID-19 patients was a reliable predictor of mortality. |
| first_indexed | 2024-04-10T00:44:54Z |
| format | Article |
| id | doaj.art-503908c7e91e475ca6c1988f766c7889 |
| institution | Directory Open Access Journal |
| issn | 2090-3049 |
| language | English |
| last_indexed | 2024-04-10T00:44:54Z |
| publishDate | 2023-01-01 |
| publisher | Hindawi Limited |
| record_format | Article |
| series | Journal of Lipids |
| spelling | doaj.art-503908c7e91e475ca6c1988f766c78892023-03-14T00:00:07ZengHindawi LimitedJournal of Lipids2090-30492023-01-01202310.1155/2023/6329873Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19Jafar Mohammadshahi0Hassan Ghobadi1Golchin Matinfar2Mohammad Hossein Boskabady3Mohammad Reza Aslani4Department of Infectious Diseases and Tropical MedicineLung Diseases Research CenterFaculty of MedicineApplied Biomedical Research CenterLung Diseases Research CenterBackground. Lipid profile and its related ratios such as total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C ratio, TC/HDL-C ratio, LDL-C/HDL-C ratio, white blood cell (WBC)/HDL-C ratio, and fasting blood glucose (FBG)/HDL-C ratio are valuable indicators that have been studied in various disorders to predict mortality. The present study was conducted with the aim of investigating the role of lipid profile ratios in predicting mortality in COVID-19 patients. Methods. At the beginning of hospitalization, laboratory tests were taken from all patients (n=300). The ability of lipid profile ratios to determine the COVID-19 severity was evaluated using receiver-operating characteristic (ROC). In addition, survival probability was determined with the average of Kaplan-Meier curves, so that the end point was death. Results. In deceased patients, TG, TC, LDL-C, HDL-C, TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C parameters were significantly lower than those of surviving patients, while WBC/HDL-C and FBG/HDL-C were significantly higher. TC (HR=3.178, 95%CI=1.064 to 9.491, P<0.05), TG (HR=3.276, 95%CI=1.111 to 9.655, P<0.05), LDL-C (HR=3.207, 95%CI=1.104 to 9.316, P<0.05), and HDL-C (HR=3.690, 95%CI=1.290 to 10.554, P<0.05), as well as TC/HDL-C (HR=3.860, 95%CI=1.289 to 11.558, P<0.05), TG/HDL-C (HR=3.860, 95%CI=1.289 to 11.558, P<0.05), LDL-C/HDL-C (HR=3.915, 95%CI=1.305 to 11.739, P<0.05), WBC/HDL-C (HR=3.232, 95%CI=1.176 to 8.885, P<0.05), and FBG/HDL-C ratios (HR=4.474, 95%CI=1.567 to 12.777, P<0.01), were detectably related to survival. The multivariate Cox regression models showed that only FBG/HDL-C ratio (HR=5.477, 95%CI=1.488 to 20.153, P<0.01) was significantly related to survival. Conclusion. The results suggested that FBG/HDL-C ratio in hospital-admitted COVID-19 patients was a reliable predictor of mortality.http://dx.doi.org/10.1155/2023/6329873 |
| spellingShingle | Jafar Mohammadshahi Hassan Ghobadi Golchin Matinfar Mohammad Hossein Boskabady Mohammad Reza Aslani Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19 Journal of Lipids |
| title | Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19 |
| title_full | Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19 |
| title_fullStr | Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19 |
| title_full_unstemmed | Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19 |
| title_short | Role of Lipid Profile and Its Relative Ratios (Cholesterol/HDL-C, Triglyceride/HDL-C, LDL-C/HDL-C, WBC/HDL-C, and FBG/HDL-C) on Admission Predicts In-Hospital Mortality COVID-19 |
| title_sort | role of lipid profile and its relative ratios cholesterol hdl c triglyceride hdl c ldl c hdl c wbc hdl c and fbg hdl c on admission predicts in hospital mortality covid 19 |
| url | http://dx.doi.org/10.1155/2023/6329873 |
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