Salivary Biomarkers for Alzheimer’s Disease and Related Disorders
Abstract The search for accessible and cost-effective biomarkers to complement current cerebrospinal fluid (CSF) and imaging biomarkers in the accurate detection of Alzheimer disease (AD) and other common neurodegenerative disorders remains a challenging task. The advances in ultra-sensitive detecti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2019-12-01
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| Series: | Neurology and Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s40120-019-00168-1 |
| _version_ | 1827284016261234688 |
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| author | Nicholas J. Ashton Mark Ide Henrik Zetterberg Kaj Blennow |
| author_facet | Nicholas J. Ashton Mark Ide Henrik Zetterberg Kaj Blennow |
| author_sort | Nicholas J. Ashton |
| collection | DOAJ |
| description | Abstract The search for accessible and cost-effective biomarkers to complement current cerebrospinal fluid (CSF) and imaging biomarkers in the accurate detection of Alzheimer disease (AD) and other common neurodegenerative disorders remains a challenging task. The advances in ultra-sensitive detection methods has highlighted blood biomarkers (e.g. amyloid-β and neurofilament light) as a valuable and realistic tool in a diagnostic or screening process. Saliva, however, is also a rich source of potential biomarkers for disease detection and offers several practical advantages over biofluids that are currently examined for neurodegenerative disorders. However, while this may be true for the general population, challenges in collecting saliva from an elderly population should be seriously considered. In this review, we begin by discussing how saliva is produced and how age-related conditions can modify saliva production and composition. We then focus on the data available which support the concept of salivary amyloid-β, tau species and novel biomarkers in detecting AD and alpha-synuclein (α-syn) in Parkinson’s disease (PD). |
| first_indexed | 2024-04-24T09:47:33Z |
| format | Article |
| id | doaj.art-503a0e85476543f4887dfc5ae23f2c85 |
| institution | Directory Open Access Journal |
| issn | 2193-8253 2193-6536 |
| language | English |
| last_indexed | 2024-04-24T09:47:33Z |
| publishDate | 2019-12-01 |
| publisher | Adis, Springer Healthcare |
| record_format | Article |
| series | Neurology and Therapy |
| spelling | doaj.art-503a0e85476543f4887dfc5ae23f2c852024-04-14T11:33:18ZengAdis, Springer HealthcareNeurology and Therapy2193-82532193-65362019-12-018S2839410.1007/s40120-019-00168-1Salivary Biomarkers for Alzheimer’s Disease and Related DisordersNicholas J. Ashton0Mark Ide1Henrik Zetterberg2Kaj Blennow3Department of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of GothenburgPeriodontology, Centre for Host Microbiome Interactions, Faculty of Dental, Oral and Craniofacial Sciences, King’s College LondonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of GothenburgDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience & Physiology, The Sahlgrenska Academy at the University of GothenburgAbstract The search for accessible and cost-effective biomarkers to complement current cerebrospinal fluid (CSF) and imaging biomarkers in the accurate detection of Alzheimer disease (AD) and other common neurodegenerative disorders remains a challenging task. The advances in ultra-sensitive detection methods has highlighted blood biomarkers (e.g. amyloid-β and neurofilament light) as a valuable and realistic tool in a diagnostic or screening process. Saliva, however, is also a rich source of potential biomarkers for disease detection and offers several practical advantages over biofluids that are currently examined for neurodegenerative disorders. However, while this may be true for the general population, challenges in collecting saliva from an elderly population should be seriously considered. In this review, we begin by discussing how saliva is produced and how age-related conditions can modify saliva production and composition. We then focus on the data available which support the concept of salivary amyloid-β, tau species and novel biomarkers in detecting AD and alpha-synuclein (α-syn) in Parkinson’s disease (PD).https://doi.org/10.1007/s40120-019-00168-1Alzheimer’s diseaseAmyloid-βBiomarkersParkinson’s diseaseSalivaTau |
| spellingShingle | Nicholas J. Ashton Mark Ide Henrik Zetterberg Kaj Blennow Salivary Biomarkers for Alzheimer’s Disease and Related Disorders Neurology and Therapy Alzheimer’s disease Amyloid-β Biomarkers Parkinson’s disease Saliva Tau |
| title | Salivary Biomarkers for Alzheimer’s Disease and Related Disorders |
| title_full | Salivary Biomarkers for Alzheimer’s Disease and Related Disorders |
| title_fullStr | Salivary Biomarkers for Alzheimer’s Disease and Related Disorders |
| title_full_unstemmed | Salivary Biomarkers for Alzheimer’s Disease and Related Disorders |
| title_short | Salivary Biomarkers for Alzheimer’s Disease and Related Disorders |
| title_sort | salivary biomarkers for alzheimer s disease and related disorders |
| topic | Alzheimer’s disease Amyloid-β Biomarkers Parkinson’s disease Saliva Tau |
| url | https://doi.org/10.1007/s40120-019-00168-1 |
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