SHH medulloblastoma and very early onset of bowel polyps in a child with PTEN hamartoma tumor syndrome

SHH medulloblastoma and very early onset of bowel polyps in a child with PTEN hamartoma tumor syndrome

Phosphatase and tensin homolog (PTEN) hamartoma tumor syndrome (PHTS) is a cancer predisposition syndrome characterized by an increased risk of developing benign and malignant tumors, caused by germline pathogenic variants of the PTEN tumour suppressor gene. PTEN gene variants often present in child...

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Bibliographic Details
Main Authors: Anna Maria Caroleo, Silvia Rotulo, Emanuele Agolini, Marina Macchiaiolo, Luigi Boccuto, Manila Antonelli, Giovanna Stefania Colafati, Antonella Cacchione, Giacomina Megaro, Andrea Carai, Maria Antonietta De Ioris, Mariachiara Lodi, Assunta Tornesello, Valeria Simone, Filippo Torroni, Giuseppe Cinalli, Angela Mastronuzzi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
cancer predisposition syndrome (CPS)
pediatric
PTHS
medulloblastoma (MB)
intestinal polyp
PTEN hamartoma tumor syndrome
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1228389/full

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