CBA (4-chloro-2-(2-chlorophenoxy)acetamido) benzoic acid) inhibits TMEM206 mediated currents and TMEM206 does not contribute to acid-induced cell death in colorectal cancer cells

CBA (4-chloro-2-(2-chlorophenoxy)acetamido) benzoic acid) inhibits TMEM206 mediated currents and TMEM206 does not contribute to acid-induced cell death in colorectal cancer cells

Introduction: Upon activation at low pH, TMEM206 conducts Cl− ions across plasma and vesicular membranes. In a (patho)physiological context, TMEM206 was reported to contribute to acid-induced cell death in neurons, kidney and cervical epithelial cells. We investigated the role of TMEM206 in acid-ind...

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Bibliographic Details
Main Authors: Sven Kappel, Korollus Melek, Daniela Ross-Kaschitza, Barbara Hauert, Christian E. Gerber, Martin Lochner, Christine Peinelt
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Pharmacology
Subjects:
TMEM206
PAORAC
ASOR
small molecule inhibitor
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1369513/full

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