Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs
The presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques. The orexin A-positive cells were identified with some of the endocrine cells in the stom...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2009-08-01
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| Series: | European Journal of Histochemistry |
| Online Access: | http://www.ejh.it/index.php/ejh/article/view/1221 |
| _version_ | 1818807218595692544 |
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| author | C Dall’Aglio L Pascucci F Mercati A Giontella V Pedini P Scocco P Ceccarelli |
| author_facet | C Dall’Aglio L Pascucci F Mercati A Giontella V Pedini P Scocco P Ceccarelli |
| author_sort | C Dall’Aglio |
| collection | DOAJ |
| description | The presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques. The orexin A-positive cells were identified with some of the endocrine cells in the stomach and in the duodenum; they were both of the open and closed type and were lacking in the large intestine. In the stomach, a large subset of orexin A-positive cells also showed gastrin-like immunoreactivity while, in the duodenum, many of them seemed to store serotonin. The orexin type 2 receptor-positive cells were evidenced all along the gastrointestinal tract examined, also in the large intestine, and they showed the same morphological characteristics as those positive to orexin A. Moreover, the immunohistochemical techniques revealed intense positivity for both orexin A and orexin type 2 receptor in the neurons and fibers of the enteric nervous system. A large subset of orexin A-positive neurons seemed to store substance P. |
| first_indexed | 2024-12-18T19:22:10Z |
| format | Article |
| id | doaj.art-503cbe040ac84ec5a6e7f86f09354999 |
| institution | Directory Open Access Journal |
| issn | 1121-760X 2038-8306 |
| language | English |
| last_indexed | 2024-12-18T19:22:10Z |
| publishDate | 2009-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj.art-503cbe040ac84ec5a6e7f86f093549992022-12-21T20:55:58ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062009-08-0152422923610.4081/1221837Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogsC Dall’AglioL PascucciF MercatiA GiontellaV PediniP ScoccoP CeccarelliThe presence and distribution of cells positive to orexin A (OXA) and to orexin type 2 receptor (OX2R) were investigated in the gastrointestinal tract of neonatal dogs by means of immunohistochemical techniques. The orexin A-positive cells were identified with some of the endocrine cells in the stomach and in the duodenum; they were both of the open and closed type and were lacking in the large intestine. In the stomach, a large subset of orexin A-positive cells also showed gastrin-like immunoreactivity while, in the duodenum, many of them seemed to store serotonin. The orexin type 2 receptor-positive cells were evidenced all along the gastrointestinal tract examined, also in the large intestine, and they showed the same morphological characteristics as those positive to orexin A. Moreover, the immunohistochemical techniques revealed intense positivity for both orexin A and orexin type 2 receptor in the neurons and fibers of the enteric nervous system. A large subset of orexin A-positive neurons seemed to store substance P.http://www.ejh.it/index.php/ejh/article/view/1221 |
| spellingShingle | C Dall’Aglio L Pascucci F Mercati A Giontella V Pedini P Scocco P Ceccarelli Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs European Journal of Histochemistry |
| title | Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs |
| title_full | Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs |
| title_fullStr | Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs |
| title_full_unstemmed | Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs |
| title_short | Identification of orexin A- and orexin type 2 receptor-positive cells in the gastrointestinal tract of neonatal dogs |
| title_sort | identification of orexin a and orexin type 2 receptor positive cells in the gastrointestinal tract of neonatal dogs |
| url | http://www.ejh.it/index.php/ejh/article/view/1221 |
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