Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative Review
<i>Background</i>: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease. The aim of this review was to present the general characteristics of orally administered nonsteroidal anti-inflammatory drugs (NSAIDs) and to present the efficacy of NSAIDs in the treatmen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/3/219 |
| _version_ | 1797413384854962176 |
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| author | Marcin Derwich Maria Mitus-Kenig Elzbieta Pawlowska |
| author_facet | Marcin Derwich Maria Mitus-Kenig Elzbieta Pawlowska |
| author_sort | Marcin Derwich |
| collection | DOAJ |
| description | <i>Background</i>: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease. The aim of this review was to present the general characteristics of orally administered nonsteroidal anti-inflammatory drugs (NSAIDs) and to present the efficacy of NSAIDs in the treatment of TMJ OA. <i>Methods</i>: PubMed database was analyzed with the keywords: “(temporomandibular joint) AND ((disorders) OR (osteoarthritis) AND (treatment)) AND (nonsteroidal anti-inflammatory drug)”. After screening of 180 results, 6 studies have been included in this narrative review. <i>Results and Conclusions</i>: Nonsteroidal anti-inflammatory drugs are one of the most commonly used drugs for alleviation of pain localized in the orofacial area. The majority of articles predominantly examined and described diclofenac sodium in the treatment of pain in the course of TMJ OA. Because of the limited number of randomized studies evaluating the efficacy of NSAIDs in the treatment of TMJ OA, as well as high heterogeneity of published researches, it seems impossible to draw up unequivocal recommendations for the usage of NSAIDs in the treatment of TMJ OA. However, it is highly recommended to use the lowest effective dose of NSAIDs for the shortest possible time. Moreover, in patients with increased risk of gastrointestinal complications, supplementary gastroprotective agents should be prescribed. |
| first_indexed | 2024-03-09T05:17:06Z |
| format | Article |
| id | doaj.art-503d42c8a2ed44f585549b619ded8131 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T05:17:06Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-503d42c8a2ed44f585549b619ded81312023-12-03T12:44:43ZengMDPI AGPharmaceuticals1424-82472021-03-0114321910.3390/ph14030219Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative ReviewMarcin Derwich0Maria Mitus-Kenig1Elzbieta Pawlowska2ORTODENT, Specialist Orthodontic Private Practice in Grudziadz, 86-300 Grudziadz, PolandDepartment of Experimental Dentistry and Prophylaxis, Medical College, Jagiellonian University in Krakow, 31-008 Krakow, PolandDepartment of Orthodontics, Medical University of Lodz, 90-419 Lodz, Poland<i>Background</i>: Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative joint disease. The aim of this review was to present the general characteristics of orally administered nonsteroidal anti-inflammatory drugs (NSAIDs) and to present the efficacy of NSAIDs in the treatment of TMJ OA. <i>Methods</i>: PubMed database was analyzed with the keywords: “(temporomandibular joint) AND ((disorders) OR (osteoarthritis) AND (treatment)) AND (nonsteroidal anti-inflammatory drug)”. After screening of 180 results, 6 studies have been included in this narrative review. <i>Results and Conclusions</i>: Nonsteroidal anti-inflammatory drugs are one of the most commonly used drugs for alleviation of pain localized in the orofacial area. The majority of articles predominantly examined and described diclofenac sodium in the treatment of pain in the course of TMJ OA. Because of the limited number of randomized studies evaluating the efficacy of NSAIDs in the treatment of TMJ OA, as well as high heterogeneity of published researches, it seems impossible to draw up unequivocal recommendations for the usage of NSAIDs in the treatment of TMJ OA. However, it is highly recommended to use the lowest effective dose of NSAIDs for the shortest possible time. Moreover, in patients with increased risk of gastrointestinal complications, supplementary gastroprotective agents should be prescribed.https://www.mdpi.com/1424-8247/14/3/219temporomandibular joint osteoarthritisNSAIDtreatment of temporomandibular joint disorders |
| spellingShingle | Marcin Derwich Maria Mitus-Kenig Elzbieta Pawlowska Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative Review Pharmaceuticals temporomandibular joint osteoarthritis NSAID treatment of temporomandibular joint disorders |
| title | Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative Review |
| title_full | Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative Review |
| title_fullStr | Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative Review |
| title_full_unstemmed | Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative Review |
| title_short | Orally Administered NSAIDs—General Characteristics and Usage in the Treatment of Temporomandibular Joint Osteoarthritis—A Narrative Review |
| title_sort | orally administered nsaids general characteristics and usage in the treatment of temporomandibular joint osteoarthritis a narrative review |
| topic | temporomandibular joint osteoarthritis NSAID treatment of temporomandibular joint disorders |
| url | https://www.mdpi.com/1424-8247/14/3/219 |
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