Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by progressive motor neuron degeneration. Although several studies on genes involved in ALS have substantially expanded and improved our understanding of ALS pathogenesis, the exact molecular mechanisms underlyin...
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MDPI AG
2020-09-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/10/10/675 |
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| author | Hyun-Jun Choi Sun Joo Cha Jang-Won Lee Hyung-Jun Kim Kiyoung Kim |
| author_facet | Hyun-Jun Choi Sun Joo Cha Jang-Won Lee Hyung-Jun Kim Kiyoung Kim |
| author_sort | Hyun-Jun Choi |
| collection | DOAJ |
| description | Amyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by progressive motor neuron degeneration. Although several studies on genes involved in ALS have substantially expanded and improved our understanding of ALS pathogenesis, the exact molecular mechanisms underlying this disease remain poorly understood. Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine-protein kinase that plays a critical role in the regulation of various cellular signaling pathways. Dysregulation of GSK3β activity in neuronal cells has been implicated in the pathogenesis of neurodegenerative diseases. Previous research indicates that GSK3β inactivation plays a neuroprotective role in ALS pathogenesis. GSK3β activity shows an increase in various ALS models and patients. Furthermore, GSK3β inhibition can suppress the defective phenotypes caused by SOD, TDP-43, and FUS expression in various models. This review focuses on the most recent studies related to the therapeutic effect of GSK3β in ALS and provides an overview of how the dysfunction of GSK3β activity contributes to ALS pathogenesis. |
| first_indexed | 2024-03-10T16:01:39Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T16:01:39Z |
| publishDate | 2020-09-01 |
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| spelling | doaj.art-504094f26f7d4a838cc8f01f6dfe94d12023-11-20T15:11:54ZengMDPI AGBrain Sciences2076-34252020-09-01101067510.3390/brainsci10100675Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral SclerosisHyun-Jun Choi0Sun Joo Cha1Jang-Won Lee2Hyung-Jun Kim3Kiyoung Kim4Department of Integrated Biomedical Science, Soonchunhyang University, Cheonan 31151, KoreaDepartment of Medical Science, Soonchunhyang University, Asan 31538, KoreaDepartment of Integrated Bio-industry, Sejong University, Seoul 05006, KoreaDementia Research Group, Korea Brain Research Institute (KBRI), Daegu 41068, KoreaDepartment of Medical Science, Soonchunhyang University, Asan 31538, KoreaAmyotrophic lateral sclerosis (ALS) is a common neurodegenerative disease characterized by progressive motor neuron degeneration. Although several studies on genes involved in ALS have substantially expanded and improved our understanding of ALS pathogenesis, the exact molecular mechanisms underlying this disease remain poorly understood. Glycogen synthase kinase 3 (GSK3) is a multifunctional serine/threonine-protein kinase that plays a critical role in the regulation of various cellular signaling pathways. Dysregulation of GSK3β activity in neuronal cells has been implicated in the pathogenesis of neurodegenerative diseases. Previous research indicates that GSK3β inactivation plays a neuroprotective role in ALS pathogenesis. GSK3β activity shows an increase in various ALS models and patients. Furthermore, GSK3β inhibition can suppress the defective phenotypes caused by SOD, TDP-43, and FUS expression in various models. This review focuses on the most recent studies related to the therapeutic effect of GSK3β in ALS and provides an overview of how the dysfunction of GSK3β activity contributes to ALS pathogenesis.https://www.mdpi.com/2076-3425/10/10/675amyotrophic lateral sclerosisGSK3βneurodegenerative disease |
| spellingShingle | Hyun-Jun Choi Sun Joo Cha Jang-Won Lee Hyung-Jun Kim Kiyoung Kim Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis Brain Sciences amyotrophic lateral sclerosis GSK3β neurodegenerative disease |
| title | Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis |
| title_full | Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis |
| title_fullStr | Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis |
| title_full_unstemmed | Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis |
| title_short | Recent Advances on the Role of GSK3β in the Pathogenesis of Amyotrophic Lateral Sclerosis |
| title_sort | recent advances on the role of gsk3β in the pathogenesis of amyotrophic lateral sclerosis |
| topic | amyotrophic lateral sclerosis GSK3β neurodegenerative disease |
| url | https://www.mdpi.com/2076-3425/10/10/675 |
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