Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective
Tendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its intrinsic and extrinsic factors have been extensively studied, the role of physiological factors, such as hypoxia an...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/13/1/86 |
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| author | Hamzah Shahid Vivek Kumar Morya Ji-Ung Oh Jae-Hyung Kim Kyu-Cheol Noh |
| author_facet | Hamzah Shahid Vivek Kumar Morya Ji-Ung Oh Jae-Hyung Kim Kyu-Cheol Noh |
| author_sort | Hamzah Shahid |
| collection | DOAJ |
| description | Tendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its intrinsic and extrinsic factors have been extensively studied, the role of physiological factors, such as hypoxia and oxidative stress, remains largely unexplored. This review article delves into the contribution of hypoxia-associated genes and oxidative-stress-related factors to tendon degeneration, offering insights into potential therapeutic strategies. The unique aspect of this study lies in its pathway-based evidence, which sheds light on how these factors can be targeted to enhance overall tendon health. |
| first_indexed | 2024-03-08T11:06:15Z |
| format | Article |
| id | doaj.art-5040d2f9ee954933ac59e72b106ac264 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-08T11:06:15Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-5040d2f9ee954933ac59e72b106ac2642024-01-26T14:41:21ZengMDPI AGAntioxidants2076-39212024-01-011318610.3390/antiox13010086Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular PerspectiveHamzah Shahid0Vivek Kumar Morya1Ji-Ung Oh2Jae-Hyung Kim3Kyu-Cheol Noh4Dongtan Sacred Heart Hospital, Hallym University, Hwaseong-si 18450, Gyeonggi-do, Republic of KoreaDongtan Sacred Heart Hospital, Hallym University, Hwaseong-si 18450, Gyeonggi-do, Republic of KoreaDongtan Sacred Heart Hospital, Hallym University, Hwaseong-si 18450, Gyeonggi-do, Republic of KoreaDongtan Sacred Heart Hospital, Hallym University, Hwaseong-si 18450, Gyeonggi-do, Republic of KoreaDongtan Sacred Heart Hospital, Hallym University, Hwaseong-si 18450, Gyeonggi-do, Republic of KoreaTendinopathy is a debilitating condition marked by degenerative changes in the tendons. Its complex pathophysiology involves intrinsic, extrinsic, and physiological factors. While its intrinsic and extrinsic factors have been extensively studied, the role of physiological factors, such as hypoxia and oxidative stress, remains largely unexplored. This review article delves into the contribution of hypoxia-associated genes and oxidative-stress-related factors to tendon degeneration, offering insights into potential therapeutic strategies. The unique aspect of this study lies in its pathway-based evidence, which sheds light on how these factors can be targeted to enhance overall tendon health.https://www.mdpi.com/2076-3921/13/1/86tendon disordershypoxiaoxidative stresstendinopathydegenerative disorders |
| spellingShingle | Hamzah Shahid Vivek Kumar Morya Ji-Ung Oh Jae-Hyung Kim Kyu-Cheol Noh Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective Antioxidants tendon disorders hypoxia oxidative stress tendinopathy degenerative disorders |
| title | Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective |
| title_full | Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective |
| title_fullStr | Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective |
| title_full_unstemmed | Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective |
| title_short | Hypoxia-Inducible Factor and Oxidative Stress in Tendon Degeneration: A Molecular Perspective |
| title_sort | hypoxia inducible factor and oxidative stress in tendon degeneration a molecular perspective |
| topic | tendon disorders hypoxia oxidative stress tendinopathy degenerative disorders |
| url | https://www.mdpi.com/2076-3921/13/1/86 |
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