“Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most common cause of dementia. There is a growing body of evidence that dysregulation in neuronal calcium (Ca<sup>2+</sup>) signaling plays a major role in the initiation of AD pathogenesis. In particular, it is well established that Ryanodine receptor (Ry...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/13/5/1187 |
| _version_ | 1797599364848287744 |
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| author | Hua Zhang Ilya Bezprozvanny |
| author_facet | Hua Zhang Ilya Bezprozvanny |
| author_sort | Hua Zhang |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is the most common cause of dementia. There is a growing body of evidence that dysregulation in neuronal calcium (Ca<sup>2+</sup>) signaling plays a major role in the initiation of AD pathogenesis. In particular, it is well established that Ryanodine receptor (RyanR) expression levels are increased in AD neurons and Ca<sup>2+</sup> release via RyanRs is augmented in AD neurons. Autophagy is important for removing unnecessary or dysfunctional components and long-lived protein aggregates, and autophagy impairment in AD neurons has been extensively reported. In this review we discuss recent results that suggest a causal link between intracellular Ca<sup>2+</sup> signaling and lysosomal/autophagic dysregulation. These new results offer novel mechanistic insight into AD pathogenesis and may potentially lead to identification of novel therapeutic targets for treating AD and possibly other neurodegenerative disorders. |
| first_indexed | 2024-03-11T03:33:23Z |
| format | Article |
| id | doaj.art-50456470d0344644995092bebb99c40b |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-11T03:33:23Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-50456470d0344644995092bebb99c40b2023-11-18T02:09:52ZengMDPI AGLife2075-17292023-05-01135118710.3390/life13051187“Dirty Dancing” of Calcium and Autophagy in Alzheimer’s DiseaseHua Zhang0Ilya Bezprozvanny1Department of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USADepartment of Physiology, UT Southwestern Medical Center, Dallas, TX 75390, USAAlzheimer’s disease (AD) is the most common cause of dementia. There is a growing body of evidence that dysregulation in neuronal calcium (Ca<sup>2+</sup>) signaling plays a major role in the initiation of AD pathogenesis. In particular, it is well established that Ryanodine receptor (RyanR) expression levels are increased in AD neurons and Ca<sup>2+</sup> release via RyanRs is augmented in AD neurons. Autophagy is important for removing unnecessary or dysfunctional components and long-lived protein aggregates, and autophagy impairment in AD neurons has been extensively reported. In this review we discuss recent results that suggest a causal link between intracellular Ca<sup>2+</sup> signaling and lysosomal/autophagic dysregulation. These new results offer novel mechanistic insight into AD pathogenesis and may potentially lead to identification of novel therapeutic targets for treating AD and possibly other neurodegenerative disorders.https://www.mdpi.com/2075-1729/13/5/1187ryanodine receptorautophagycalcium signalingcalcineurinAlzheimer’s disease |
| spellingShingle | Hua Zhang Ilya Bezprozvanny “Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease Life ryanodine receptor autophagy calcium signaling calcineurin Alzheimer’s disease |
| title | “Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease |
| title_full | “Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease |
| title_fullStr | “Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease |
| title_full_unstemmed | “Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease |
| title_short | “Dirty Dancing” of Calcium and Autophagy in Alzheimer’s Disease |
| title_sort | dirty dancing of calcium and autophagy in alzheimer s disease |
| topic | ryanodine receptor autophagy calcium signaling calcineurin Alzheimer’s disease |
| url | https://www.mdpi.com/2075-1729/13/5/1187 |
| work_keys_str_mv | AT huazhang dirtydancingofcalciumandautophagyinalzheimersdisease AT ilyabezprozvanny dirtydancingofcalciumandautophagyinalzheimersdisease |