“Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD
Claus Vogelmeier,1 Heinrich Worth,2 Roland Buhl,3 Carl-Peter Criée,4 Nadine S Lossi,5 Claudia Mailänder,5 Peter Kardos6 1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2017-02-01
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| Series: | International Journal of COPD |
| Subjects: | |
| Online Access: | https://www.dovepress.com/ldquoreal-liferdquo-inhaled-corticosteroid-withdrawal-in-copd-a-subgro-peer-reviewed-article-COPD |
| _version_ | 1818081457289035776 |
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| author | Vogelmeier C Worth H Buhl R Criée C Lossi NS Mailänder C Kardos P |
| author_facet | Vogelmeier C Worth H Buhl R Criée C Lossi NS Mailänder C Kardos P |
| author_sort | Vogelmeier C |
| collection | DOAJ |
| description | Claus Vogelmeier,1 Heinrich Worth,2 Roland Buhl,3 Carl-Peter Criée,4 Nadine S Lossi,5 Claudia Mailänder,5 Peter Kardos6 1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, 2Facharzt Forum Fürth, Fürth, 3Pulmonary Department, Mainz University Hospital, Mainz, 4Department of Sleep and Respiratory Medicine, Evangelical Hospital Göttingen-Weende, Bovenden, 5Clinical Research, Respiratory, Novartis Pharma GmbH, Nürnberg, 6Group Practice and Centre for Allergy, Respiratory and Sleep Medicine, Red Cross Maingau Hospital, Frankfurt am Main, Germany Abstract: Many patients with chronic obstructive pulmonary disease (COPD) receive inhaled corticosteroids (ICSs) without a clear indication, and thus, the impact of ICS withdrawal on disease control is of great interest. DACCORD is a prospective, noninterventional 2-year study in the primary and secondary care throughout Germany. A subgroup of patients were taking ICS prior to entry – 1,022 patients continued to receive ICS for 2 years; physicians withdrew ICS on entry in 236 patients. Data from these two subgroups were analyzed to evaluate the impact of ICS withdrawal. Patients aged ≥40 years with COPD, initiating or changing COPD maintenance medication were recruited, excluding patients with asthma. Demographic and disease characteristics, prescribed COPD medication, COPD Assessment Test, exacerbations, and lung function were recorded. There were few differences in baseline characteristics; ICS withdrawn patients had shorter disease duration and better lung function, with 74.2% of ICS withdrawn patients not exacerbating, compared with 70.7% ICS-continued patients. During Year 1, exacerbation rates were 0.414 in the withdrawn group and 0.433 in the continued group. COPD Assessment Test total score improved from baseline in both groups. These data suggest that ICS withdrawal is possible with no increased risk of exacerbations in patients with COPD managed in the primary and secondary care. Keywords: COPD exacerbations, chronic obstructive pulmonary disease exacerbations, health-related quality of life, inhaled steroids |
| first_indexed | 2024-12-10T19:06:30Z |
| format | Article |
| id | doaj.art-5045dc8e3cf74522a1e55739cd8640da |
| institution | Directory Open Access Journal |
| issn | 1178-2005 |
| language | English |
| last_indexed | 2024-12-10T19:06:30Z |
| publishDate | 2017-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of COPD |
| spelling | doaj.art-5045dc8e3cf74522a1e55739cd8640da2022-12-22T01:36:53ZengDove Medical PressInternational Journal of COPD1178-20052017-02-01Volume 1248749431124“Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORDVogelmeier CWorth HBuhl RCriée CLossi NSMailänder CKardos PClaus Vogelmeier,1 Heinrich Worth,2 Roland Buhl,3 Carl-Peter Criée,4 Nadine S Lossi,5 Claudia Mailänder,5 Peter Kardos6 1Department of Medicine, Pulmonary and Critical Care Medicine, University Medical Center Giessen and Marburg, Philipps-University Marburg, Member of the German Center for Lung Research (DZL), Marburg, 2Facharzt Forum Fürth, Fürth, 3Pulmonary Department, Mainz University Hospital, Mainz, 4Department of Sleep and Respiratory Medicine, Evangelical Hospital Göttingen-Weende, Bovenden, 5Clinical Research, Respiratory, Novartis Pharma GmbH, Nürnberg, 6Group Practice and Centre for Allergy, Respiratory and Sleep Medicine, Red Cross Maingau Hospital, Frankfurt am Main, Germany Abstract: Many patients with chronic obstructive pulmonary disease (COPD) receive inhaled corticosteroids (ICSs) without a clear indication, and thus, the impact of ICS withdrawal on disease control is of great interest. DACCORD is a prospective, noninterventional 2-year study in the primary and secondary care throughout Germany. A subgroup of patients were taking ICS prior to entry – 1,022 patients continued to receive ICS for 2 years; physicians withdrew ICS on entry in 236 patients. Data from these two subgroups were analyzed to evaluate the impact of ICS withdrawal. Patients aged ≥40 years with COPD, initiating or changing COPD maintenance medication were recruited, excluding patients with asthma. Demographic and disease characteristics, prescribed COPD medication, COPD Assessment Test, exacerbations, and lung function were recorded. There were few differences in baseline characteristics; ICS withdrawn patients had shorter disease duration and better lung function, with 74.2% of ICS withdrawn patients not exacerbating, compared with 70.7% ICS-continued patients. During Year 1, exacerbation rates were 0.414 in the withdrawn group and 0.433 in the continued group. COPD Assessment Test total score improved from baseline in both groups. These data suggest that ICS withdrawal is possible with no increased risk of exacerbations in patients with COPD managed in the primary and secondary care. Keywords: COPD exacerbations, chronic obstructive pulmonary disease exacerbations, health-related quality of life, inhaled steroidshttps://www.dovepress.com/ldquoreal-liferdquo-inhaled-corticosteroid-withdrawal-in-copd-a-subgro-peer-reviewed-article-COPDCOPD exacerbationschronic obstructive pulmonary diseasehealth related quality of lifeinhaled steroids |
| spellingShingle | Vogelmeier C Worth H Buhl R Criée C Lossi NS Mailänder C Kardos P “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD International Journal of COPD COPD exacerbations chronic obstructive pulmonary disease health related quality of life inhaled steroids |
| title | “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD |
| title_full | “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD |
| title_fullStr | “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD |
| title_full_unstemmed | “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD |
| title_short | “Real-life” inhaled corticosteroid withdrawal in COPD: a subgroup analysis of DACCORD |
| title_sort | ldquo real life rdquo inhaled corticosteroid withdrawal in copd a subgroup analysis of daccord |
| topic | COPD exacerbations chronic obstructive pulmonary disease health related quality of life inhaled steroids |
| url | https://www.dovepress.com/ldquoreal-liferdquo-inhaled-corticosteroid-withdrawal-in-copd-a-subgro-peer-reviewed-article-COPD |
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