Functional Changes of Therapeutic Antibodies upon Exposure to Pro-Oxidative Agents

Functional Changes of Therapeutic Antibodies upon Exposure to Pro-Oxidative Agents

Therapeutic monoclonal antibodies have exerted a transformative impact on clinical practice in last two decades. However, development of a therapeutic antibody remains a complex process. Various physiochemical and functional liabilities can compromise the production or the therapeutic efficacy of an...

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Bibliographic Details
Main Authors:	Maxime Lecerf, Robin Lacombe, Alexia Kanyavuz, Jordan D. Dimitrov
Format:	Article
Language:	English
Published:	MDPI AG 2022-02-01
Series:	Antibodies
Subjects:	therapeutic antibodies antibody developability oxidation antibody polyreactivity ferrous ions hypochlorite
Online Access:	https://www.mdpi.com/2073-4468/11/1/11

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