Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study
BackgroundRecently, the association between handgrip strength (HGS) asymmetry and cognition has been revealed, but evidences are still scarce. Particularly, the association between asymmetric HGS and cognitive performance in various cognitive domains is unclear and whether this association is stable...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1191197/full |
| _version_ | 1797823696103014400 |
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| author | Wenjing Feng Wenjing Feng Mingfeng Ma Hanshu Gao Hanshu Gao Wei Yuan Ruixue Li Hui Guo Cuiying Gu Zhaoqing Sun Yao Zhang Liqiang Zheng |
| author_facet | Wenjing Feng Wenjing Feng Mingfeng Ma Hanshu Gao Hanshu Gao Wei Yuan Ruixue Li Hui Guo Cuiying Gu Zhaoqing Sun Yao Zhang Liqiang Zheng |
| author_sort | Wenjing Feng |
| collection | DOAJ |
| description | BackgroundRecently, the association between handgrip strength (HGS) asymmetry and cognition has been revealed, but evidences are still scarce. Particularly, the association between asymmetric HGS and cognitive performance in various cognitive domains is unclear and whether this association is stable across ethnic groups is unknown.MethodThe population was from a longitudinal study in rural areas of Fuxin, Liaoning, China. The Chinese version of Montreal Cognitive Assessment-Basic (MOCA-BC) was used to evaluate the cognitive function. The HGS ratio was calculated as maximal non-dominant HGS divided by maximal dominant HGS. HGS ratio <0.9 or >1.1 was classified as asymmetric dominant/non-dominant HGS, respectively. Generalized linear models were used to analyze the relationship between asymmetric HGS and cognitive function adjusted for HGS, handedness, wave, age, sex, education, ethnicity, smoking, drinking, physical labor level, BMI, hypertension, diabetes and dyslipidemia.ResultA total of 2,969 participants ≥50 years were included in this study. Adjusted for HGS and other confunding variables, there was an inverted U-shaped association between HGS ratio and MoCA-BC scores (Pnon–linear = 0.004). The association between HGS ratio and MoCA-BC scores was inconsistent among ethnic groups (Pinteraction = 0.048). In Han, only asymmetric non-dominant HGS was associated with lower cognitive scores [β = −0.67, 95% confidence interval (CI): −1.26 ∼−0.08, P = 0.027]; in Mongolians, asymmetric dominant HGS(β = −0.60, 95% CI: −1.35 ∼ 0.15, P = 0.115) and asymmetric non-dominant HGS (β = −0.56, 95% CI: −1.42 ∼ 0.31, P = 0.206) were all associated with lower cognitive scores, although no statistical significance was found. Asymmetric non-dominant HGS and lower HGS, but not asymmetric dominant HGS were all independently associated with impairment of Delayed Recall (OR = 1.35, 95% CI: 1.05 ∼ 1.74; OR per 5 kg decrease = 1.10, 95% CI: 1.01 ∼ 1.21) and Fluency (OR = 1.43, 95% CI: 1.15 ∼ 1.78; OR per 5 kg decrease = 1.10, 95% CI: 1.02 ∼ 1.19). Both asymmetric dominant HGS (OR = 1.34, 95% CI: 1.07 ∼ 1.67) and lower HGS (OR per 5 kg decrease = 1.21, 95% CI: 1.10 ∼ 1.32) were associated with impairment of visuoperception.ConclusionHGS and HGS asymmetry were all independently related to lower global cognitive performance. The association between HGS asymmetry and cognitive function varies among ethnic groups. |
| first_indexed | 2024-03-13T10:27:48Z |
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| institution | Directory Open Access Journal |
| issn | 1663-4365 |
| language | English |
| last_indexed | 2024-03-13T10:27:48Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Aging Neuroscience |
| spelling | doaj.art-5047cc36c9474f8d968d954cfd89a5002023-05-19T04:45:29ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652023-05-011510.3389/fnagi.2023.11911971191197Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional studyWenjing Feng0Wenjing Feng1Mingfeng Ma2Hanshu Gao3Hanshu Gao4Wei Yuan5Ruixue Li6Hui Guo7Cuiying Gu8Zhaoqing Sun9Yao Zhang10Liqiang Zheng11Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Cardiology, Fenyang Hospital of Shanxi Province, Fenyang, Shanxi, ChinaMinistry of Education-Shanghai Key Laboratory of Children’s Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, ChinaDepartment of Cardiology, Shengjing Hospital of China Medical University, Shenyang, ChinaDepartment of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, ChinaMinistry of Education-Shanghai Key Laboratory of Children’s Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaBackgroundRecently, the association between handgrip strength (HGS) asymmetry and cognition has been revealed, but evidences are still scarce. Particularly, the association between asymmetric HGS and cognitive performance in various cognitive domains is unclear and whether this association is stable across ethnic groups is unknown.MethodThe population was from a longitudinal study in rural areas of Fuxin, Liaoning, China. The Chinese version of Montreal Cognitive Assessment-Basic (MOCA-BC) was used to evaluate the cognitive function. The HGS ratio was calculated as maximal non-dominant HGS divided by maximal dominant HGS. HGS ratio <0.9 or >1.1 was classified as asymmetric dominant/non-dominant HGS, respectively. Generalized linear models were used to analyze the relationship between asymmetric HGS and cognitive function adjusted for HGS, handedness, wave, age, sex, education, ethnicity, smoking, drinking, physical labor level, BMI, hypertension, diabetes and dyslipidemia.ResultA total of 2,969 participants ≥50 years were included in this study. Adjusted for HGS and other confunding variables, there was an inverted U-shaped association between HGS ratio and MoCA-BC scores (Pnon–linear = 0.004). The association between HGS ratio and MoCA-BC scores was inconsistent among ethnic groups (Pinteraction = 0.048). In Han, only asymmetric non-dominant HGS was associated with lower cognitive scores [β = −0.67, 95% confidence interval (CI): −1.26 ∼−0.08, P = 0.027]; in Mongolians, asymmetric dominant HGS(β = −0.60, 95% CI: −1.35 ∼ 0.15, P = 0.115) and asymmetric non-dominant HGS (β = −0.56, 95% CI: −1.42 ∼ 0.31, P = 0.206) were all associated with lower cognitive scores, although no statistical significance was found. Asymmetric non-dominant HGS and lower HGS, but not asymmetric dominant HGS were all independently associated with impairment of Delayed Recall (OR = 1.35, 95% CI: 1.05 ∼ 1.74; OR per 5 kg decrease = 1.10, 95% CI: 1.01 ∼ 1.21) and Fluency (OR = 1.43, 95% CI: 1.15 ∼ 1.78; OR per 5 kg decrease = 1.10, 95% CI: 1.02 ∼ 1.19). Both asymmetric dominant HGS (OR = 1.34, 95% CI: 1.07 ∼ 1.67) and lower HGS (OR per 5 kg decrease = 1.21, 95% CI: 1.10 ∼ 1.32) were associated with impairment of visuoperception.ConclusionHGS and HGS asymmetry were all independently related to lower global cognitive performance. The association between HGS asymmetry and cognitive function varies among ethnic groups.https://www.frontiersin.org/articles/10.3389/fnagi.2023.1191197/fullhandgrip strength asymmetryhandgrip strengthcognitive functioncross-sectional studyethnicity |
| spellingShingle | Wenjing Feng Wenjing Feng Mingfeng Ma Hanshu Gao Hanshu Gao Wei Yuan Ruixue Li Hui Guo Cuiying Gu Zhaoqing Sun Yao Zhang Liqiang Zheng Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study Frontiers in Aging Neuroscience handgrip strength asymmetry handgrip strength cognitive function cross-sectional study ethnicity |
| title | Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study |
| title_full | Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study |
| title_fullStr | Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study |
| title_full_unstemmed | Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study |
| title_short | Association between handgrip strength asymmetry and cognitive function across ethnicity in rural China: a cross-sectional study |
| title_sort | association between handgrip strength asymmetry and cognitive function across ethnicity in rural china a cross sectional study |
| topic | handgrip strength asymmetry handgrip strength cognitive function cross-sectional study ethnicity |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2023.1191197/full |
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