Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the Literature
Pancreatic adenocarcinoma carries a devastating prognosis. For locally advanced and metastatic disease, several chemotherapeutic regimens are currently being used. Over the past years, novel approaches have included targeting EGFR, NTRK, PARP, K-Ras as well as stroma and fibrosis, leading to approva...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/11/10/1469 |
| _version_ | 1797515212856754176 |
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| author | Konstantin Schlick Dominik Kiem Richard Greil |
| author_facet | Konstantin Schlick Dominik Kiem Richard Greil |
| author_sort | Konstantin Schlick |
| collection | DOAJ |
| description | Pancreatic adenocarcinoma carries a devastating prognosis. For locally advanced and metastatic disease, several chemotherapeutic regimens are currently being used. Over the past years, novel approaches have included targeting EGFR, NTRK, PARP, K-Ras as well as stroma and fibrosis, leading to approval of NTRK and PARP inhibitors. Moreover, immune check point inhibitors and different combinational approaches involving immunotherapeutic agents are being investigated in many clinical trials. MiRNAs represent a novel tool and are thought to greatly improve management by allowing for earlier diagnosis and for more precise guidance of treatment. |
| first_indexed | 2024-03-10T06:42:20Z |
| format | Article |
| id | doaj.art-5048985886ec4236a8b1cf24dbcfcf59 |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T06:42:20Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-5048985886ec4236a8b1cf24dbcfcf592023-11-22T17:34:02ZengMDPI AGBiomolecules2218-273X2021-10-011110146910.3390/biom11101469Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the LiteratureKonstantin Schlick0Dominik Kiem1Richard Greil2Oncologic Center, Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, 5020 Salzburg, AustriaOncologic Center, Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, 5020 Salzburg, AustriaOncologic Center, Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, 5020 Salzburg, AustriaPancreatic adenocarcinoma carries a devastating prognosis. For locally advanced and metastatic disease, several chemotherapeutic regimens are currently being used. Over the past years, novel approaches have included targeting EGFR, NTRK, PARP, K-Ras as well as stroma and fibrosis, leading to approval of NTRK and PARP inhibitors. Moreover, immune check point inhibitors and different combinational approaches involving immunotherapeutic agents are being investigated in many clinical trials. MiRNAs represent a novel tool and are thought to greatly improve management by allowing for earlier diagnosis and for more precise guidance of treatment.https://www.mdpi.com/2218-273X/11/10/1469pancreatic cancermiRNAschemoresistancetargeted therapyimmunotherapy |
| spellingShingle | Konstantin Schlick Dominik Kiem Richard Greil Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the Literature Biomolecules pancreatic cancer miRNAs chemoresistance targeted therapy immunotherapy |
| title | Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the Literature |
| title_full | Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the Literature |
| title_fullStr | Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the Literature |
| title_full_unstemmed | Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the Literature |
| title_short | Recent Advances in Pancreatic Cancer: Novel Prognostic Biomarkers and Targeted Therapy—A Review of the Literature |
| title_sort | recent advances in pancreatic cancer novel prognostic biomarkers and targeted therapy a review of the literature |
| topic | pancreatic cancer miRNAs chemoresistance targeted therapy immunotherapy |
| url | https://www.mdpi.com/2218-273X/11/10/1469 |
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