Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device
Abstract Sarcopenia is a progressive loss of muscle mass and strength that is associated with increasing the risk of falls, musculoskeletal diseases, and chronic metabolic diseases. However, the animal models adopted to study sarcopenia face limitations since the functional tests conducted on human...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-10-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-44748-6 |
| _version_ | 1827711601257480192 |
|---|---|
| author | Seung-Rok Kim Ey-In Lee Yongnyun Kim Sang Wouk Cho Namki Hong Yumie Rhee Jin-Woo Park |
| author_facet | Seung-Rok Kim Ey-In Lee Yongnyun Kim Sang Wouk Cho Namki Hong Yumie Rhee Jin-Woo Park |
| author_sort | Seung-Rok Kim |
| collection | DOAJ |
| description | Abstract Sarcopenia is a progressive loss of muscle mass and strength that is associated with increasing the risk of falls, musculoskeletal diseases, and chronic metabolic diseases. However, the animal models adopted to study sarcopenia face limitations since the functional tests conducted on human cannot be directly adapted to animals because the animals do not follow instructions. Moreover, current preclinical research tools for muscle function assessment, such as the rotarod, grip strength, and treadmill, have limitations, including low-intensity simple movements, evaluator subjectivity, and limited power indicators. Hence, in this study, we present a new jumping-power assessment tool in a preclinical rodent model to demonstrate muscle functions. To overcome the light weight and command issues in the rodent model, we developed an electrical stimulation-assisted jump power assessment device. Precisely, the device utilizes a load cell with a 0.1 g resolution and a 50 points/s data acquisition rate to capture the short period of the mouse jump. Additionally, interdigitated electrodes are used to electrically stimulate the mice and make them jump. While our primary focus in this article is the validation of the newly developed jump power assessment device, it is worth noting that this tool has several potential utilities. These include the phenotypic comparison of sarcopenia models, the exploration of muscle function reduction mechanisms, muscle function-related blood biomarkers, and the evaluation of drug intervention effects. |
| first_indexed | 2024-03-10T17:56:53Z |
| format | Article |
| id | doaj.art-504ba48158c34ce3bce265a6669aef1b |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T17:56:53Z |
| publishDate | 2023-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-504ba48158c34ce3bce265a6669aef1b2023-11-20T09:08:49ZengNature PortfolioScientific Reports2045-23222023-10-0113111010.1038/s41598-023-44748-6Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted deviceSeung-Rok Kim0Ey-In Lee1Yongnyun Kim2Sang Wouk Cho3Namki Hong4Yumie Rhee5Jin-Woo Park6Department of Materials Science and Engineering, Yonsei UniversityDepartment of Materials Science and Engineering, Yonsei UniversityYonsei University Health SystemDepartment of Integrative Medicine, Yonsei University College of MedicineInstitue for Innovation in Digital Healthcare (IIDH), Severance HospitalDepartment of Internal Medicine, Severance Hospital, Endocrine Research Institute, Yonsei University College of MedicineDepartment of Materials Science and Engineering, Yonsei UniversityAbstract Sarcopenia is a progressive loss of muscle mass and strength that is associated with increasing the risk of falls, musculoskeletal diseases, and chronic metabolic diseases. However, the animal models adopted to study sarcopenia face limitations since the functional tests conducted on human cannot be directly adapted to animals because the animals do not follow instructions. Moreover, current preclinical research tools for muscle function assessment, such as the rotarod, grip strength, and treadmill, have limitations, including low-intensity simple movements, evaluator subjectivity, and limited power indicators. Hence, in this study, we present a new jumping-power assessment tool in a preclinical rodent model to demonstrate muscle functions. To overcome the light weight and command issues in the rodent model, we developed an electrical stimulation-assisted jump power assessment device. Precisely, the device utilizes a load cell with a 0.1 g resolution and a 50 points/s data acquisition rate to capture the short period of the mouse jump. Additionally, interdigitated electrodes are used to electrically stimulate the mice and make them jump. While our primary focus in this article is the validation of the newly developed jump power assessment device, it is worth noting that this tool has several potential utilities. These include the phenotypic comparison of sarcopenia models, the exploration of muscle function reduction mechanisms, muscle function-related blood biomarkers, and the evaluation of drug intervention effects.https://doi.org/10.1038/s41598-023-44748-6 |
| spellingShingle | Seung-Rok Kim Ey-In Lee Yongnyun Kim Sang Wouk Cho Namki Hong Yumie Rhee Jin-Woo Park Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device Scientific Reports |
| title | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
| title_full | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
| title_fullStr | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
| title_full_unstemmed | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
| title_short | Preclinical assessment of rodent jumping power with a novel electrical stimulation-assisted device |
| title_sort | preclinical assessment of rodent jumping power with a novel electrical stimulation assisted device |
| url | https://doi.org/10.1038/s41598-023-44748-6 |
| work_keys_str_mv | AT seungrokkim preclinicalassessmentofrodentjumpingpowerwithanovelelectricalstimulationassisteddevice AT eyinlee preclinicalassessmentofrodentjumpingpowerwithanovelelectricalstimulationassisteddevice AT yongnyunkim preclinicalassessmentofrodentjumpingpowerwithanovelelectricalstimulationassisteddevice AT sangwoukcho preclinicalassessmentofrodentjumpingpowerwithanovelelectricalstimulationassisteddevice AT namkihong preclinicalassessmentofrodentjumpingpowerwithanovelelectricalstimulationassisteddevice AT yumierhee preclinicalassessmentofrodentjumpingpowerwithanovelelectricalstimulationassisteddevice AT jinwoopark preclinicalassessmentofrodentjumpingpowerwithanovelelectricalstimulationassisteddevice |