Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure
ObjectiveTo explore the valuably influential factors and improve the diagnostic accuracy and efficiency of 99mTc-methoxyisobutylisonitrile (MIBI) uptake in parathyroids of secondary hyperparathyroidism (SHPT) patients with chronic renal failure (CRF).MethodsThe correlation analysis was performed bet...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.915279/full |
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| author | Dafu Yu Dafu Yu Lin Zou Yao Jin Mingxiang Wei Xiaoqun Wu Lingjing Zuo Mingkang Wu Yong Jiang |
| author_facet | Dafu Yu Dafu Yu Lin Zou Yao Jin Mingxiang Wei Xiaoqun Wu Lingjing Zuo Mingkang Wu Yong Jiang |
| author_sort | Dafu Yu |
| collection | DOAJ |
| description | ObjectiveTo explore the valuably influential factors and improve the diagnostic accuracy and efficiency of 99mTc-methoxyisobutylisonitrile (MIBI) uptake in parathyroids of secondary hyperparathyroidism (SHPT) patients with chronic renal failure (CRF).MethodsThe correlation analysis was performed between clinical indices related to CRF and 99mTc-MIBI uptake intensity TBR (the gray value mean ratio between the parathyroid target and the bilateral neck background, semiquantitatively calculated with ImageJ software). All clinical indices and TBRs were compared by a three- or two-level grouping method of MIBI uptake, which was visually qualitatively assessed. The three-level grouping method comprised slight, medium, and high groups with little, faint, and distinct MIBI concentration in parathyroids, respectively. The two-level grouping method comprised insignificant and significant groups with TBR greater than or less than 0.49–0.71, respectively.ResultsMIBI uptake was significantly positively related to patient age, CRF course, hemodialysis vintage, serum parathyroid hormone (PTH), and alkaline phosphatase (AKP) but was significantly negatively related to serum uric acid (UA). MIBI washout was significantly positively related to patient age but was significantly negatively related to serum phosphorus (P) and calcium (Ca) × P. Oral administration of calcitriol and calcium could significantly reduce the MIBI uptake. MIBI uptake tendency might alter. Such seven indices, namely the MIBI uptake, CRF course, hemodialysis vintage, serum AKP, calcium, cysteine proteinase inhibitor C, and PTH, were comparable between the slight and medium groups but were significantly different between the slight and high groups or between the medium and high groups. The above seven indices plus blood urea nitrogen/creatinine were all significantly different between the insignificant and significant groups. All above significances were with P < 0.05.ConclusionsPatient age, CRF course, hemodialysis vintage, serum PTH, AKP, UA, phosphorus, Ca × P, oral administration of calcitriol and calcium, and parathyroids themselves can significantly influence MIBI uptake in parathyroids of SHPT patients with CRF. The two-level grouping method of MIBI intensity should be adopted to qualitatively diagnose the MIBI uptake. |
| first_indexed | 2024-04-11T11:46:29Z |
| format | Article |
| id | doaj.art-504c421c8480494d826cc82af37f1d73 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-11T11:46:29Z |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-504c421c8480494d826cc82af37f1d732022-12-22T04:25:32ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-09-011310.3389/fendo.2022.915279915279Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failureDafu Yu0Dafu Yu1Lin Zou2Yao Jin3Mingxiang Wei4Xiaoqun Wu5Lingjing Zuo6Mingkang Wu7Yong Jiang8Department of Nuclear Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, ChinaDepartment of Nuclear Medicine, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Nuclear Medicine, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Nuclear Medicine, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Respiratory Disease, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Nuclear Medicine, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Nuclear Medicine, The First People’s Hospital of Yunnan Province, Kunming, ChinaDepartment of Nuclear Medicine, The First People’s Hospital of Yunnan Province, Kunming, ChinaObjectiveTo explore the valuably influential factors and improve the diagnostic accuracy and efficiency of 99mTc-methoxyisobutylisonitrile (MIBI) uptake in parathyroids of secondary hyperparathyroidism (SHPT) patients with chronic renal failure (CRF).MethodsThe correlation analysis was performed between clinical indices related to CRF and 99mTc-MIBI uptake intensity TBR (the gray value mean ratio between the parathyroid target and the bilateral neck background, semiquantitatively calculated with ImageJ software). All clinical indices and TBRs were compared by a three- or two-level grouping method of MIBI uptake, which was visually qualitatively assessed. The three-level grouping method comprised slight, medium, and high groups with little, faint, and distinct MIBI concentration in parathyroids, respectively. The two-level grouping method comprised insignificant and significant groups with TBR greater than or less than 0.49–0.71, respectively.ResultsMIBI uptake was significantly positively related to patient age, CRF course, hemodialysis vintage, serum parathyroid hormone (PTH), and alkaline phosphatase (AKP) but was significantly negatively related to serum uric acid (UA). MIBI washout was significantly positively related to patient age but was significantly negatively related to serum phosphorus (P) and calcium (Ca) × P. Oral administration of calcitriol and calcium could significantly reduce the MIBI uptake. MIBI uptake tendency might alter. Such seven indices, namely the MIBI uptake, CRF course, hemodialysis vintage, serum AKP, calcium, cysteine proteinase inhibitor C, and PTH, were comparable between the slight and medium groups but were significantly different between the slight and high groups or between the medium and high groups. The above seven indices plus blood urea nitrogen/creatinine were all significantly different between the insignificant and significant groups. All above significances were with P < 0.05.ConclusionsPatient age, CRF course, hemodialysis vintage, serum PTH, AKP, UA, phosphorus, Ca × P, oral administration of calcitriol and calcium, and parathyroids themselves can significantly influence MIBI uptake in parathyroids of SHPT patients with CRF. The two-level grouping method of MIBI intensity should be adopted to qualitatively diagnose the MIBI uptake.https://www.frontiersin.org/articles/10.3389/fendo.2022.915279/fullsecondary hyperparathyroidismsemiquantitative assessmentchronic renal failureparathyroids99mTc-methoxyisobutylisonitrile (MIBI) |
| spellingShingle | Dafu Yu Dafu Yu Lin Zou Yao Jin Mingxiang Wei Xiaoqun Wu Lingjing Zuo Mingkang Wu Yong Jiang Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure Frontiers in Endocrinology secondary hyperparathyroidism semiquantitative assessment chronic renal failure parathyroids 99mTc-methoxyisobutylisonitrile (MIBI) |
| title | Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure |
| title_full | Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure |
| title_fullStr | Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure |
| title_full_unstemmed | Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure |
| title_short | Semiquantitative assessment of 99mTc-MIBI uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure |
| title_sort | semiquantitative assessment of 99mtc mibi uptake in parathyroids of secondary hyperparathyroidism patients with chronic renal failure |
| topic | secondary hyperparathyroidism semiquantitative assessment chronic renal failure parathyroids 99mTc-methoxyisobutylisonitrile (MIBI) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.915279/full |
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