Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC)
Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/7/641 |
| _version_ | 1797561798822461440 |
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| author | Valentina Mercurio Alessandra Cuomo Christian Cadeddu Dessalvi Martino Deidda Daniela Di Lisi Giuseppina Novo Roberta Manganaro Concetta Zito Ciro Santoro Pietro Ameri Paolo Spallarossa Eleonora Arboscello Carlo Gabriele Tocchetti Claudia Penna |
| author_facet | Valentina Mercurio Alessandra Cuomo Christian Cadeddu Dessalvi Martino Deidda Daniela Di Lisi Giuseppina Novo Roberta Manganaro Concetta Zito Ciro Santoro Pietro Ameri Paolo Spallarossa Eleonora Arboscello Carlo Gabriele Tocchetti Claudia Penna |
| author_sort | Valentina Mercurio |
| collection | DOAJ |
| description | Metabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS are also cancer risk factors, such as the consumption of high calorie-food or high fat intake, low fibre intake, and sedentary lifestyle. Other common aspects of both cancer and MetS are oxidative stress and inflammation. In addition, some anticancer treatments can induce cardiotoxicity, including, for instance, left ventricular (LV) dysfunction and heart failure (HF), endothelial dysfunction and hypertension. In this review, we analyse several aspects of MetS, cancer and cardiotoxicity from anticancer drugs. In particular, we focus on oxidative stress in ageing, cancer and CV diseases, and we analyse the connections among CV risk factors, cancer and cardiotoxicity from anticancer drugs. |
| first_indexed | 2024-03-10T18:19:45Z |
| format | Article |
| id | doaj.art-504debdf79ed4918a2ef91d29cac4f77 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T18:19:45Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-504debdf79ed4918a2ef91d29cac4f772023-11-20T07:26:21ZengMDPI AGAntioxidants2076-39212020-07-019764110.3390/antiox9070641Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC)Valentina Mercurio0Alessandra Cuomo1Christian Cadeddu Dessalvi2Martino Deidda3Daniela Di Lisi4Giuseppina Novo5Roberta Manganaro6Concetta Zito7Ciro Santoro8Pietro Ameri9Paolo Spallarossa10Eleonora Arboscello11Carlo Gabriele Tocchetti12Claudia Penna13Department of Translational Medical Sciences, Federico II University, 80131 Naples, ItalyDepartment of Translational Medical Sciences, Federico II University, 80131 Naples, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, ItalyDepartment of Medical Sciences and Public Health, University of Cagliari, 09042 Cagliari, ItalyCardiology Unit AUOP Policlinico, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, ItalyCardiology Unit AUOP Policlinico, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, ItalyCardiology with Coronary Intensive Care Unit, Department of Clinical and Experimental Medicine, University Hospital Policlinico “G. Martino”, University of Messina, 98124 Messina, ItalyCardiology with Coronary Intensive Care Unit, Department of Clinical and Experimental Medicine, University Hospital Policlinico “G. Martino”, University of Messina, 98124 Messina, ItalyDepartment of Advanced Biomedical Sciences, Federico II University, 80131 Naples, ItalyCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy—IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16121 Genova, ItalyCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy—IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16121 Genova, ItalyCardiovascular Disease Unit, IRCCS Ospedale Policlinico San Martino, Genova, Italy—IRCCS Italian Cardiovascular Network & Department of Internal Medicine, University of Genova, 16121 Genova, ItalyDepartment of Translational Medical Sciences, Federico II University, 80131 Naples, ItalyDepartment of Clinical and Biological Sciences, University of Turin, 10043 Torino, ItalyMetabolic syndrome (MetS) is a well established risk factor for cardiovascular (CV) diseases. In addition, several studies indicate that MetS correlates with the increased risk of cancer in adults. The mechanisms linking MetS and cancer are not fully understood. Several risk factors involved in MetS are also cancer risk factors, such as the consumption of high calorie-food or high fat intake, low fibre intake, and sedentary lifestyle. Other common aspects of both cancer and MetS are oxidative stress and inflammation. In addition, some anticancer treatments can induce cardiotoxicity, including, for instance, left ventricular (LV) dysfunction and heart failure (HF), endothelial dysfunction and hypertension. In this review, we analyse several aspects of MetS, cancer and cardiotoxicity from anticancer drugs. In particular, we focus on oxidative stress in ageing, cancer and CV diseases, and we analyse the connections among CV risk factors, cancer and cardiotoxicity from anticancer drugs.https://www.mdpi.com/2076-3921/9/7/641cancercardiovascular toxicity from anticancer drugscardiovascular diseaseageingmetabolic syndrome |
| spellingShingle | Valentina Mercurio Alessandra Cuomo Christian Cadeddu Dessalvi Martino Deidda Daniela Di Lisi Giuseppina Novo Roberta Manganaro Concetta Zito Ciro Santoro Pietro Ameri Paolo Spallarossa Eleonora Arboscello Carlo Gabriele Tocchetti Claudia Penna Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC) Antioxidants cancer cardiovascular toxicity from anticancer drugs cardiovascular disease ageing metabolic syndrome |
| title | Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC) |
| title_full | Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC) |
| title_fullStr | Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC) |
| title_full_unstemmed | Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC) |
| title_short | Redox Imbalances in Ageing and Metabolic Alterations: Implications in Cancer and Cardiac Diseases. An Overview from the Working Group of Cardiotoxicity and Cardioprotection of the Italian Society of Cardiology (SIC) |
| title_sort | redox imbalances in ageing and metabolic alterations implications in cancer and cardiac diseases an overview from the working group of cardiotoxicity and cardioprotection of the italian society of cardiology sic |
| topic | cancer cardiovascular toxicity from anticancer drugs cardiovascular disease ageing metabolic syndrome |
| url | https://www.mdpi.com/2076-3921/9/7/641 |
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