Nicotinamide Riboside—The Current State of Research and Therapeutic Uses
Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD<sup>+</sup>) precursors, due to its numerous potential health benefits mediated via elevated NAD<sup>+</sup> content in the body. NAD<sup>+</sup> is an es...
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| Format: | Article |
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MDPI AG
2020-05-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/12/6/1616 |
| _version_ | 1797566492159508480 |
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| author | Mario Mehmel Nina Jovanović Urs Spitz |
| author_facet | Mario Mehmel Nina Jovanović Urs Spitz |
| author_sort | Mario Mehmel |
| collection | DOAJ |
| description | Nicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD<sup>+</sup>) precursors, due to its numerous potential health benefits mediated via elevated NAD<sup>+</sup> content in the body. NAD<sup>+</sup> is an essential coenzyme that plays important roles in various metabolic pathways and increasing its overall content has been confirmed as a valuable strategy for treating a wide variety of pathophysiological conditions. Accumulating evidence on NRs’ health benefits has validated its efficiency across numerous animal and human studies for the treatment of a number of cardiovascular, neurodegenerative, and metabolic disorders. As the prevalence and morbidity of these conditions increases in modern society, the great necessity has arisen for a rapid translation of NR to therapeutic use and further establishment of its availability as a nutritional supplement. Here, we summarize currently available data on NR effects on metabolism, and several neurodegenerative and cardiovascular disorders, through to its application as a treatment for specific pathophysiological conditions. In addition, we have reviewed newly published research on the application of NR as a potential therapy against infections with several pathogens, including SARS-CoV-2. Additionally, to support rapid NR translation to therapeutics, the challenges related to its bioavailability and safety are addressed, together with the advantages of NR to other NAD<sup>+</sup> precursors. |
| first_indexed | 2024-03-10T19:27:36Z |
| format | Article |
| id | doaj.art-504f9d06ba904535bdffbdfff8bafcfc |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T19:27:36Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-504f9d06ba904535bdffbdfff8bafcfc2023-11-20T02:23:39ZengMDPI AGNutrients2072-66432020-05-01126161610.3390/nu12061616Nicotinamide Riboside—The Current State of Research and Therapeutic UsesMario Mehmel0Nina Jovanović1Urs Spitz2Biosynth Carbosynth, Rietlistrasse 4, 9422 Staad, SwitzerlandFaculty of Biology, Department of Biochemistry and Molecular Biology, Institute of Physiology and Biochemistry, University of Belgrade, Studentski Trg 1, 11000 Belgrade, SerbiaBiosynth Carbosynth, Axis House, High Street, Compton, Berkshire RG20 6NL, UKNicotinamide riboside (NR) has recently become one of the most studied nicotinamide adenine dinucleotide (NAD<sup>+</sup>) precursors, due to its numerous potential health benefits mediated via elevated NAD<sup>+</sup> content in the body. NAD<sup>+</sup> is an essential coenzyme that plays important roles in various metabolic pathways and increasing its overall content has been confirmed as a valuable strategy for treating a wide variety of pathophysiological conditions. Accumulating evidence on NRs’ health benefits has validated its efficiency across numerous animal and human studies for the treatment of a number of cardiovascular, neurodegenerative, and metabolic disorders. As the prevalence and morbidity of these conditions increases in modern society, the great necessity has arisen for a rapid translation of NR to therapeutic use and further establishment of its availability as a nutritional supplement. Here, we summarize currently available data on NR effects on metabolism, and several neurodegenerative and cardiovascular disorders, through to its application as a treatment for specific pathophysiological conditions. In addition, we have reviewed newly published research on the application of NR as a potential therapy against infections with several pathogens, including SARS-CoV-2. Additionally, to support rapid NR translation to therapeutics, the challenges related to its bioavailability and safety are addressed, together with the advantages of NR to other NAD<sup>+</sup> precursors.https://www.mdpi.com/2072-6643/12/6/1616nicotinamide ribosidenicotinamide adenine dinucleotidesupplementationsafetybioavailabilitymetabolic disorders |
| spellingShingle | Mario Mehmel Nina Jovanović Urs Spitz Nicotinamide Riboside—The Current State of Research and Therapeutic Uses Nutrients nicotinamide riboside nicotinamide adenine dinucleotide supplementation safety bioavailability metabolic disorders |
| title | Nicotinamide Riboside—The Current State of Research and Therapeutic Uses |
| title_full | Nicotinamide Riboside—The Current State of Research and Therapeutic Uses |
| title_fullStr | Nicotinamide Riboside—The Current State of Research and Therapeutic Uses |
| title_full_unstemmed | Nicotinamide Riboside—The Current State of Research and Therapeutic Uses |
| title_short | Nicotinamide Riboside—The Current State of Research and Therapeutic Uses |
| title_sort | nicotinamide riboside the current state of research and therapeutic uses |
| topic | nicotinamide riboside nicotinamide adenine dinucleotide supplementation safety bioavailability metabolic disorders |
| url | https://www.mdpi.com/2072-6643/12/6/1616 |
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