Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of Highly Active Antiretroviral Therapy
Background: Genetic variants and haplotypes of the interleukin-10 (IL10) gene have been shown to affect clinical outcomes, including the incidence of opportunistic infections (OIs), in HIV-infected patients. This study investigated the effect of IL10 gene variants on susceptibility to OIs in HIV-inf...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Clinical Microbiology
2019-03-01
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| Series: | Annals of Clinical Microbiology |
| Subjects: | |
| Online Access: | https://www.acm.or.kr/article_aws/?num=KJCM2019_14 |
| Summary: | Background: Genetic variants and haplotypes of the
interleukin-10 (IL10) gene have been shown to affect
clinical outcomes, including the incidence of opportunistic
infections (OIs), in HIV-infected patients. This
study investigated the effect of IL10 gene variants on
susceptibility to OIs in HIV-infected Korean patients in
the era of highly active antiretroviral therapy (HAART).Methods: Eighty-five HIV-infected patients receiving
HAART were enrolled in the study. OIs were diagnosed
based on the published criteria of the Korean
Society for AIDS. Three promoter SNPs and four
haplotype-tagging SNPs (htSNPs) of IL10 were selected
and genotyped. The haplotypes were reconstructed
according to the genotyping data and
linkage disequilibrium (LD) status of these SNPs.Results: During the study, 38 OIs developed in 23 of
the 85 patients (27.1%), at a rate of 1.7 episodes/
patient. Carrying the minor alleles at the rs1518111,
rs3024490, and rs1800871 SNPs had a protective effect
against OIs (adjusted P=0.035). Among the seven
assessed variants, only three possible haplotypes
were observed. The second most common haplotype,
which was composed of the rs1518111 minor
allele and the rs3021094 major allele showed a protective
effect against OIs (P=0.0153).Conclusion: This study demonstrated that some IL10
genetic variants and haplotypes are associated with
protective effects against OIs in the era of HAART.
These data suggest the potential of two htSNPs,
rs1518111 and rs3021094, as markers revealing the
genetic association of IL10 in Koreans. This is the
first report on the association of IL10 with OIs in
HIV-infected Korean patients in the era of HAART.
(Ann Clin Microbiol 2019;22:14-22) |
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| ISSN: | 2288-0585 2288-6850 |