Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of Highly Active Antiretroviral Therapy
Background: Genetic variants and haplotypes of the interleukin-10 (IL10) gene have been shown to affect clinical outcomes, including the incidence of opportunistic infections (OIs), in HIV-infected patients. This study investigated the effect of IL10 gene variants on susceptibility to OIs in HIV-inf...
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| Format: | Article |
| Language: | English |
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Korean Society of Clinical Microbiology
2019-03-01
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| Series: | Annals of Clinical Microbiology |
| Subjects: | |
| Online Access: | https://www.acm.or.kr/article_aws/?num=KJCM2019_14 |
| _version_ | 1818108375084302336 |
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| author | In-Suk Kim Hyung-Hoi Kim Chulhun L. Chang1 |
| author_facet | In-Suk Kim Hyung-Hoi Kim Chulhun L. Chang1 |
| author_sort | In-Suk Kim |
| collection | DOAJ |
| description | Background: Genetic variants and haplotypes of the
interleukin-10 (IL10) gene have been shown to affect
clinical outcomes, including the incidence of opportunistic
infections (OIs), in HIV-infected patients. This
study investigated the effect of IL10 gene variants on
susceptibility to OIs in HIV-infected Korean patients in
the era of highly active antiretroviral therapy (HAART).Methods: Eighty-five HIV-infected patients receiving
HAART were enrolled in the study. OIs were diagnosed
based on the published criteria of the Korean
Society for AIDS. Three promoter SNPs and four
haplotype-tagging SNPs (htSNPs) of IL10 were selected
and genotyped. The haplotypes were reconstructed
according to the genotyping data and
linkage disequilibrium (LD) status of these SNPs.Results: During the study, 38 OIs developed in 23 of
the 85 patients (27.1%), at a rate of 1.7 episodes/
patient. Carrying the minor alleles at the rs1518111,
rs3024490, and rs1800871 SNPs had a protective effect
against OIs (adjusted P=0.035). Among the seven
assessed variants, only three possible haplotypes
were observed. The second most common haplotype,
which was composed of the rs1518111 minor
allele and the rs3021094 major allele showed a protective
effect against OIs (P=0.0153).Conclusion: This study demonstrated that some IL10
genetic variants and haplotypes are associated with
protective effects against OIs in the era of HAART.
These data suggest the potential of two htSNPs,
rs1518111 and rs3021094, as markers revealing the
genetic association of IL10 in Koreans. This is the
first report on the association of IL10 with OIs in
HIV-infected Korean patients in the era of HAART.
(Ann Clin Microbiol 2019;22:14-22) |
| first_indexed | 2024-12-11T02:14:21Z |
| format | Article |
| id | doaj.art-5050c75ace4e4ea1acdf46f71e229d03 |
| institution | Directory Open Access Journal |
| issn | 2288-0585 2288-6850 |
| language | English |
| last_indexed | 2024-12-11T02:14:21Z |
| publishDate | 2019-03-01 |
| publisher | Korean Society of Clinical Microbiology |
| record_format | Article |
| series | Annals of Clinical Microbiology |
| spelling | doaj.art-5050c75ace4e4ea1acdf46f71e229d032022-12-22T01:24:12ZengKorean Society of Clinical MicrobiologyAnnals of Clinical Microbiology2288-05852288-68502019-03-01221142210.5145/ACM.2019.22.1.14KJCM2019_14Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of Highly Active Antiretroviral TherapyIn-Suk Kim0Hyung-Hoi Kim1Chulhun L. Chang12 Department of Laboratory Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine Department of Laboratory Medicine and Biomedical Research Institute, Pusan National University Hospital,Pusan National University School of Medicine, Busan Department of Laboratory Medicine and Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine Background: Genetic variants and haplotypes of the interleukin-10 (IL10) gene have been shown to affect clinical outcomes, including the incidence of opportunistic infections (OIs), in HIV-infected patients. This study investigated the effect of IL10 gene variants on susceptibility to OIs in HIV-infected Korean patients in the era of highly active antiretroviral therapy (HAART).Methods: Eighty-five HIV-infected patients receiving HAART were enrolled in the study. OIs were diagnosed based on the published criteria of the Korean Society for AIDS. Three promoter SNPs and four haplotype-tagging SNPs (htSNPs) of IL10 were selected and genotyped. The haplotypes were reconstructed according to the genotyping data and linkage disequilibrium (LD) status of these SNPs.Results: During the study, 38 OIs developed in 23 of the 85 patients (27.1%), at a rate of 1.7 episodes/ patient. Carrying the minor alleles at the rs1518111, rs3024490, and rs1800871 SNPs had a protective effect against OIs (adjusted P=0.035). Among the seven assessed variants, only three possible haplotypes were observed. The second most common haplotype, which was composed of the rs1518111 minor allele and the rs3021094 major allele showed a protective effect against OIs (P=0.0153).Conclusion: This study demonstrated that some IL10 genetic variants and haplotypes are associated with protective effects against OIs in the era of HAART. These data suggest the potential of two htSNPs, rs1518111 and rs3021094, as markers revealing the genetic association of IL10 in Koreans. This is the first report on the association of IL10 with OIs in HIV-infected Korean patients in the era of HAART. (Ann Clin Microbiol 2019;22:14-22)https://www.acm.or.kr/article_aws/?num=KJCM2019_14haplotypehivil10opportunistic infectionssusceptibility |
| spellingShingle | In-Suk Kim Hyung-Hoi Kim Chulhun L. Chang1 Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of Highly Active Antiretroviral Therapy Annals of Clinical Microbiology haplotype hiv il10 opportunistic infections susceptibility |
| title | Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of
Highly Active Antiretroviral Therapy |
| title_full | Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of
Highly Active Antiretroviral Therapy |
| title_fullStr | Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of
Highly Active Antiretroviral Therapy |
| title_full_unstemmed | Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of
Highly Active Antiretroviral Therapy |
| title_short | Genetic Variants and Haplotypes in the IL10 Gene and Their Association with Opportunistic Infections among HIV-Infected Patients in Korea in the Era of
Highly Active Antiretroviral Therapy |
| title_sort | genetic variants and haplotypes in the il10 gene and their association with opportunistic infections among hiv infected patients in korea in the era of highly active antiretroviral therapy |
| topic | haplotype hiv il10 opportunistic infections susceptibility |
| url | https://www.acm.or.kr/article_aws/?num=KJCM2019_14 |
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