Postnatal DNA demethylation and its role in tissue maturation
Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.
Bibliographic Details
| Main Authors: |
Yitzhak Reizel,
Ofra Sabag,
Yael Skversky,
Adam Spiro,
Benjamin Steinberg,
Diana Bernstein,
Amber Wang,
Julia Kieckhaefer,
Catherine Li,
Eli Pikarsky,
Rena Levin-Klein,
Alon Goren,
Klaus Rajewsky,
Klaus H. Kaestner,
Howard Cedar |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2018-05-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-04456-6
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