Postnatal DNA demethylation and its role in tissue maturation
Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-04456-6 |
| _version_ | 1818841312329203712 |
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| author | Yitzhak Reizel Ofra Sabag Yael Skversky Adam Spiro Benjamin Steinberg Diana Bernstein Amber Wang Julia Kieckhaefer Catherine Li Eli Pikarsky Rena Levin-Klein Alon Goren Klaus Rajewsky Klaus H. Kaestner Howard Cedar |
| author_facet | Yitzhak Reizel Ofra Sabag Yael Skversky Adam Spiro Benjamin Steinberg Diana Bernstein Amber Wang Julia Kieckhaefer Catherine Li Eli Pikarsky Rena Levin-Klein Alon Goren Klaus Rajewsky Klaus H. Kaestner Howard Cedar |
| author_sort | Yitzhak Reizel |
| collection | DOAJ |
| description | Here the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver. |
| first_indexed | 2024-12-19T04:24:05Z |
| format | Article |
| id | doaj.art-50520c8d9e7d4a71beda66e83fbcd1e0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:24:05Z |
| publishDate | 2018-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-50520c8d9e7d4a71beda66e83fbcd1e02022-12-21T20:36:04ZengNature PortfolioNature Communications2041-17232018-05-019111110.1038/s41467-018-04456-6Postnatal DNA demethylation and its role in tissue maturationYitzhak Reizel0Ofra Sabag1Yael Skversky2Adam Spiro3Benjamin Steinberg4Diana Bernstein5Amber Wang6Julia Kieckhaefer7Catherine Li8Eli Pikarsky9Rena Levin-Klein10Alon Goren11Klaus Rajewsky12Klaus H. Kaestner13Howard Cedar14Department of Developmental Biology and Cancer Research, Hebrew University Medical SchoolDepartment of Developmental Biology and Cancer Research, Hebrew University Medical SchoolDepartment of Developmental Biology and Cancer Research, Hebrew University Medical SchoolDepartment of Developmental Biology and Cancer Research, Hebrew University Medical SchoolDepartment of Developmental Biology and Cancer Research, Hebrew University Medical SchoolDepartment of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research CenterDepartment of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research CenterDepartment of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research CenterBroad Technology Labs (BTL), The Broad Institute of Harvard and MITDepartment of Developmental Biology and Cancer Research, Hebrew University Medical SchoolDepartment of Biochemistry, Molecular Biology and Biophysics, University of MinnesotaBroad Technology Labs (BTL), The Broad Institute of Harvard and MITImmune Regulation and Cancer Max-Delbrück-Centrum für, Molekulare Medizin (MDC)Department of Genetics and Institute for Diabetes Obesity and Metabolism, Perelman School of Medicine, University of Pennsylvania, 12-126 Translational Research CenterDepartment of Developmental Biology and Cancer Research, Hebrew University Medical SchoolHere the authors show that a large fraction of the tissue-specific methylation pattern is generated postnatally. These changes, which occur in response to hormone signaling, appear to play a major role in the regulation of gene expression and tissue maturation in the liver.https://doi.org/10.1038/s41467-018-04456-6 |
| spellingShingle | Yitzhak Reizel Ofra Sabag Yael Skversky Adam Spiro Benjamin Steinberg Diana Bernstein Amber Wang Julia Kieckhaefer Catherine Li Eli Pikarsky Rena Levin-Klein Alon Goren Klaus Rajewsky Klaus H. Kaestner Howard Cedar Postnatal DNA demethylation and its role in tissue maturation Nature Communications |
| title | Postnatal DNA demethylation and its role in tissue maturation |
| title_full | Postnatal DNA demethylation and its role in tissue maturation |
| title_fullStr | Postnatal DNA demethylation and its role in tissue maturation |
| title_full_unstemmed | Postnatal DNA demethylation and its role in tissue maturation |
| title_short | Postnatal DNA demethylation and its role in tissue maturation |
| title_sort | postnatal dna demethylation and its role in tissue maturation |
| url | https://doi.org/10.1038/s41467-018-04456-6 |
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