Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial
Introduction: Postoperative Nausea and Vomiting (PONV) is a common entity following surgical procedure. It may result into serious complication like aspiration of gastric contents, prolonged recovery period. Palonosetron is a selective serotonin antagonist that is 5HT3 receptor antagonist with littl...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2020-03-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://jcdr.net/articles/PDF/13595/43467_F(SHU)_PF1(AG_SHU)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
| _version_ | 1818876171302993920 |
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| author | Deepak Premnarayan Gupta Vijay Chandak |
| author_facet | Deepak Premnarayan Gupta Vijay Chandak |
| author_sort | Deepak Premnarayan Gupta |
| collection | DOAJ |
| description | Introduction: Postoperative Nausea and Vomiting (PONV) is a common entity following surgical procedure. It may result into serious complication like aspiration of gastric contents, prolonged recovery period. Palonosetron is a selective serotonin antagonist that is 5HT3 receptor antagonist with little to no affinity for other receptors and has a longer duration of action. Ondansetron is also a 5HT3 receptor antagonist with shorter duration of action and some side effects.
Aim: To compare the effectiveness of ondansetron and palonosetron for the prevention of PONV following upper abdominal surgeries.
Materials and Methods: This prospective single-blind study included 120 patients randomly assigned to the palonosetron group (n=60) or the ondansetron group (n=60). Using the chi-square test and calculating p-value, the two groups were compared.
Results: The incidence of nausea, vomiting and use of rescue antiemetic was significantly less in palonosetron group as compared to ondansetron group.
Conclusion: From the study, it can be concluded that palonosetron at a dose of 0.075 mg is safe, with lesser side effects and proved more effective than ondansetron 4 mg in prevention of PONV. |
| first_indexed | 2024-12-19T13:38:09Z |
| format | Article |
| id | doaj.art-50529ee4c866427bb9c51d2b3a7b0f6e |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-19T13:38:09Z |
| publishDate | 2020-03-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-50529ee4c866427bb9c51d2b3a7b0f6e2022-12-21T20:19:06ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2020-03-01143UC01UC0410.7860/JCDR/2020/43467.13595Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control TrialDeepak Premnarayan Gupta0Vijay Chandak1Junior Resident, Department of Anaesthesia, DMIMS, Sawangi, Wardha, Maharashtra, India.Associate Professor, Department of Anaesthesia, DMIMS, Sawangi, Wardha, Maharashtra, India.Introduction: Postoperative Nausea and Vomiting (PONV) is a common entity following surgical procedure. It may result into serious complication like aspiration of gastric contents, prolonged recovery period. Palonosetron is a selective serotonin antagonist that is 5HT3 receptor antagonist with little to no affinity for other receptors and has a longer duration of action. Ondansetron is also a 5HT3 receptor antagonist with shorter duration of action and some side effects. Aim: To compare the effectiveness of ondansetron and palonosetron for the prevention of PONV following upper abdominal surgeries. Materials and Methods: This prospective single-blind study included 120 patients randomly assigned to the palonosetron group (n=60) or the ondansetron group (n=60). Using the chi-square test and calculating p-value, the two groups were compared. Results: The incidence of nausea, vomiting and use of rescue antiemetic was significantly less in palonosetron group as compared to ondansetron group. Conclusion: From the study, it can be concluded that palonosetron at a dose of 0.075 mg is safe, with lesser side effects and proved more effective than ondansetron 4 mg in prevention of PONV.https://jcdr.net/articles/PDF/13595/43467_F(SHU)_PF1(AG_SHU)_PFA(KM)_PB(AG_KM)_PN(SL).pdfadverse effectantiemeticpostoperative |
| spellingShingle | Deepak Premnarayan Gupta Vijay Chandak Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial Journal of Clinical and Diagnostic Research adverse effect antiemetic postoperative |
| title | Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial |
| title_full | Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial |
| title_fullStr | Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial |
| title_full_unstemmed | Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial |
| title_short | Comparative Study of Ondansetron and Palonosetron for Prevention of Nausea and Vomiting Following Upper Abdominal Surgeries under General Anaesthesia: A Randomised Control Trial |
| title_sort | comparative study of ondansetron and palonosetron for prevention of nausea and vomiting following upper abdominal surgeries under general anaesthesia a randomised control trial |
| topic | adverse effect antiemetic postoperative |
| url | https://jcdr.net/articles/PDF/13595/43467_F(SHU)_PF1(AG_SHU)_PFA(KM)_PB(AG_KM)_PN(SL).pdf |
| work_keys_str_mv | AT deepakpremnarayangupta comparativestudyofondansetronandpalonosetronforpreventionofnauseaandvomitingfollowingupperabdominalsurgeriesundergeneralanaesthesiaarandomisedcontroltrial AT vijaychandak comparativestudyofondansetronandpalonosetronforpreventionofnauseaandvomitingfollowingupperabdominalsurgeriesundergeneralanaesthesiaarandomisedcontroltrial |