High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease
The cerebrospinal fluid (CSF) plays an important role in homeostasis of the brain. We previously demonstrated that major CSF proteins such as lipocalin-type prostaglandin D2 synthase (L-PGDS) and transferrin (Tf) that are biosynthesized in the brain could be biomarkers of altered CSF production. Her...
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MDPI AG
2022-04-01
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| Online Access: | https://www.mdpi.com/2218-1989/12/4/355 |
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| author | Kyoka Hoshi Mayumi Kanno Mitsunari Abe Takenobu Murakami Yoshikazu Ugawa Aya Goto Takashi Honda Takashi Saito Takaomi C. Saido Yoshiki Yamaguchi Masakazu Miyajima Katsutoshi Furukawa Hiroyuki Arai Yasuhiro Hashimoto |
| author_facet | Kyoka Hoshi Mayumi Kanno Mitsunari Abe Takenobu Murakami Yoshikazu Ugawa Aya Goto Takashi Honda Takashi Saito Takaomi C. Saido Yoshiki Yamaguchi Masakazu Miyajima Katsutoshi Furukawa Hiroyuki Arai Yasuhiro Hashimoto |
| author_sort | Kyoka Hoshi |
| collection | DOAJ |
| description | The cerebrospinal fluid (CSF) plays an important role in homeostasis of the brain. We previously demonstrated that major CSF proteins such as lipocalin-type prostaglandin D2 synthase (L-PGDS) and transferrin (Tf) that are biosynthesized in the brain could be biomarkers of altered CSF production. Here we report that the levels of these brain-derived CSF proteins correlated well with each other across various neurodegenerative diseases, including Alzheimer’s disease (AD). In addition, protein levels tended to be increased in the CSF samples of AD patients compared with the other diseases. Patients at memory clinics were classified into three categories, consisting of AD (<i>n</i> = 61), mild cognitive impairment (MCI) (<i>n</i> = 42), and cognitively normal (CN) (<i>n</i> = 23), with MMSE scores of 20.4 ± 4.2, 26.9 ± 1.7, and 29.0 ± 1.6, respectively. In each category, CSF protein levels were highly correlated with each other. In CN subjects, increased CSF protein levels correlated well with those of AD markers, including amyloid-β and tau protein, whereas in MCI and AD subjects, correlations declined with AD markers except p-tau. Future follow-up on each clinical subject may provide a clue that the CSF proteins would be AD-related biomarkers. |
| first_indexed | 2024-03-09T04:23:50Z |
| format | Article |
| id | doaj.art-50545c60ae09428fabf80d93d2a74bda |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-09T04:23:50Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-50545c60ae09428fabf80d93d2a74bda2023-12-03T13:43:07ZengMDPI AGMetabolites2218-19892022-04-0112435510.3390/metabo12040355High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s DiseaseKyoka Hoshi0Mayumi Kanno1Mitsunari Abe2Takenobu Murakami3Yoshikazu Ugawa4Aya Goto5Takashi Honda6Takashi Saito7Takaomi C. Saido8Yoshiki Yamaguchi9Masakazu Miyajima10Katsutoshi Furukawa11Hiroyuki Arai12Yasuhiro Hashimoto13Department of Biochemistry, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Forensic Medicine, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Neurology, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Neurology, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Neurology, Fukushima Medical University, Fukushima 960-1295, JapanCenter for Integrated Science and Humanities, Fukushima Medical University, Fukushima 960-1295, JapanDepartment of Forensic Medicine, Fukushima Medical University, Fukushima 960-1295, JapanLaboratory of Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198, JapanLaboratory of Proteolytic Neuroscience, RIKEN Center for Brain Science, Saitama 351-0198, JapanStructural Glyocobiology Team, RIKEN Global Research Cluster, Saitama 351-0198, JapanDepartment of Neurosurgery, Juntendo University, Tokyo 113-8421, JapanInstitute of Development, Aging and Cancer, Tohoku University, Miyagi 980-8575, JapanInstitute of Development, Aging and Cancer, Tohoku University, Miyagi 980-8575, JapanDepartment of Forensic Medicine, Fukushima Medical University, Fukushima 960-1295, JapanThe cerebrospinal fluid (CSF) plays an important role in homeostasis of the brain. We previously demonstrated that major CSF proteins such as lipocalin-type prostaglandin D2 synthase (L-PGDS) and transferrin (Tf) that are biosynthesized in the brain could be biomarkers of altered CSF production. Here we report that the levels of these brain-derived CSF proteins correlated well with each other across various neurodegenerative diseases, including Alzheimer’s disease (AD). In addition, protein levels tended to be increased in the CSF samples of AD patients compared with the other diseases. Patients at memory clinics were classified into three categories, consisting of AD (<i>n</i> = 61), mild cognitive impairment (MCI) (<i>n</i> = 42), and cognitively normal (CN) (<i>n</i> = 23), with MMSE scores of 20.4 ± 4.2, 26.9 ± 1.7, and 29.0 ± 1.6, respectively. In each category, CSF protein levels were highly correlated with each other. In CN subjects, increased CSF protein levels correlated well with those of AD markers, including amyloid-β and tau protein, whereas in MCI and AD subjects, correlations declined with AD markers except p-tau. Future follow-up on each clinical subject may provide a clue that the CSF proteins would be AD-related biomarkers.https://www.mdpi.com/2218-1989/12/4/355Alzheimer’s diseaseneurodegenerative diseasescerebrospinal fluidlipocalin-type prostaglandin D2 synthasetransferrin |
| spellingShingle | Kyoka Hoshi Mayumi Kanno Mitsunari Abe Takenobu Murakami Yoshikazu Ugawa Aya Goto Takashi Honda Takashi Saito Takaomi C. Saido Yoshiki Yamaguchi Masakazu Miyajima Katsutoshi Furukawa Hiroyuki Arai Yasuhiro Hashimoto High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease Metabolites Alzheimer’s disease neurodegenerative diseases cerebrospinal fluid lipocalin-type prostaglandin D2 synthase transferrin |
| title | High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease |
| title_full | High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease |
| title_fullStr | High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease |
| title_full_unstemmed | High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease |
| title_short | High Correlation among Brain-Derived Major Protein Levels in Cerebrospinal Fluid: Implication for Amyloid-Beta and Tau Protein Changes in Alzheimer’s Disease |
| title_sort | high correlation among brain derived major protein levels in cerebrospinal fluid implication for amyloid beta and tau protein changes in alzheimer s disease |
| topic | Alzheimer’s disease neurodegenerative diseases cerebrospinal fluid lipocalin-type prostaglandin D2 synthase transferrin |
| url | https://www.mdpi.com/2218-1989/12/4/355 |
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