A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes
Transcription regulation requires recruitment of different epigenetic regulators to the chromatin. Here the authors provide evidence that an H3K36me3 reader PWWP2A forms a variant NuRD complex and plays a role in regulating transcription and histone acetylation dynamics.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06235-9 |
| _version_ | 1819040172828786688 |
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| author | Tianyi Zhang Guifeng Wei Christopher J. Millard Roman Fischer Rebecca Konietzny Benedikt M. Kessler John W. R. Schwabe Neil Brockdorff |
| author_facet | Tianyi Zhang Guifeng Wei Christopher J. Millard Roman Fischer Rebecca Konietzny Benedikt M. Kessler John W. R. Schwabe Neil Brockdorff |
| author_sort | Tianyi Zhang |
| collection | DOAJ |
| description | Transcription regulation requires recruitment of different epigenetic regulators to the chromatin. Here the authors provide evidence that an H3K36me3 reader PWWP2A forms a variant NuRD complex and plays a role in regulating transcription and histone acetylation dynamics. |
| first_indexed | 2024-12-21T09:04:53Z |
| format | Article |
| id | doaj.art-5054f4fdda3244658206c728b04b321a |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:04:53Z |
| publishDate | 2018-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-5054f4fdda3244658206c728b04b321a2022-12-21T19:09:23ZengNature PortfolioNature Communications2041-17232018-09-019111410.1038/s41467-018-06235-9A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genesTianyi Zhang0Guifeng Wei1Christopher J. Millard2Roman Fischer3Rebecca Konietzny4Benedikt M. Kessler5John W. R. Schwabe6Neil Brockdorff7Developmental Epigenetics, Department of Biochemistry, University of OxfordDevelopmental Epigenetics, Department of Biochemistry, University of OxfordLeicester Institute for Structural and Chemical Biology and Department of Molecular and Cell Biology, University of LeicesterTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt DriveTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt DriveTarget Discovery Institute, Nuffield Department of Medicine, University of Oxford, Roosevelt DriveLeicester Institute for Structural and Chemical Biology and Department of Molecular and Cell Biology, University of LeicesterDevelopmental Epigenetics, Department of Biochemistry, University of OxfordTranscription regulation requires recruitment of different epigenetic regulators to the chromatin. Here the authors provide evidence that an H3K36me3 reader PWWP2A forms a variant NuRD complex and plays a role in regulating transcription and histone acetylation dynamics.https://doi.org/10.1038/s41467-018-06235-9 |
| spellingShingle | Tianyi Zhang Guifeng Wei Christopher J. Millard Roman Fischer Rebecca Konietzny Benedikt M. Kessler John W. R. Schwabe Neil Brockdorff A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes Nature Communications |
| title | A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes |
| title_full | A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes |
| title_fullStr | A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes |
| title_full_unstemmed | A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes |
| title_short | A variant NuRD complex containing PWWP2A/B excludes MBD2/3 to regulate transcription at active genes |
| title_sort | variant nurd complex containing pwwp2a b excludes mbd2 3 to regulate transcription at active genes |
| url | https://doi.org/10.1038/s41467-018-06235-9 |
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