In vitro and in silico analysis of galanthine from Zephyranthes carinata as an inhibitor of acetylcholinesterase

In vitro and in silico analysis of galanthine from Zephyranthes carinata as an inhibitor of acetylcholinesterase

Zephyranthes carinata Herb., a specie of the Amaryllidoideae subfamily, has been reported to have inhibitory activity against acetylcholinesterase. However, scientific evidence related to their bioactive alkaloids has been lacking. Thus, this study describes the isolation of the alkaloids of this pl...

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Bibliographic Details
Main Authors: Karina Sierra, Jean Paulo de Andrade, Luciana R. Tallini, Edison H. Osorio, Osvaldo Yañéz, Manuel Isaías Osorio, Nora H. Oleas, Olimpo García-Beltrán, Warley de S. Borges, Jaume Bastida, Edison Osorio, Natalie Cortes
Format: Article
Language:English
Published: Elsevier 2022-06-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Amaryllidaceae alkaloids
Galanthine
Acetylcholinesterase inhibition
Molecular docking
Molecular dynamics
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222200405X

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