Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger
Effects of a free radical scavenger, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), on ischemia/reperfusion-induced dysfunctions of rat striatal dopaminergic neurons were examined using in vivo brain microdialysis. During transient forebrain ischemia, dopamine levels in dialysates were elevated 14...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2007-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1347861319342847 |
| _version_ | 1811310966407692288 |
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| author | Yoshinori Akiyama Soichi Miwa |
| author_facet | Yoshinori Akiyama Soichi Miwa |
| author_sort | Yoshinori Akiyama |
| collection | DOAJ |
| description | Effects of a free radical scavenger, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), on ischemia/reperfusion-induced dysfunctions of rat striatal dopaminergic neurons were examined using in vivo brain microdialysis. During transient forebrain ischemia, dopamine levels in dialysates were elevated 140-fold above controls but rapidly recovered after reperfusion. The increase in dopamine levels induced by high K+ stimulation after reperfusion was far smaller than that of the controls. Pretreatment with edaravone but not post-treatment dose-dependently improved the response to high K+ but not the massive dopamine increase during ischemia. These results suggest that free radicals produced during ischemia play more important roles in ischemia/reperfusion-induced dysfunctions of dopaminergic neurons. Keywords:: transient forebrain ischemia, dopamine release, edaravone |
| first_indexed | 2024-04-13T10:09:42Z |
| format | Article |
| id | doaj.art-5057f969cefc4d9096c2a56a20840bc5 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-04-13T10:09:42Z |
| publishDate | 2007-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-5057f969cefc4d9096c2a56a20840bc52022-12-22T02:50:59ZengElsevierJournal of Pharmacological Sciences1347-86132007-01-01104199102Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical ScavengerYoshinori Akiyama0Soichi Miwa1Department of Neurosurgery, Tenri Hospital, Nara 632-8552, JapanDepartment of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan; Corresponding author. smiwa@med.hokudai.ac.jpEffects of a free radical scavenger, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), on ischemia/reperfusion-induced dysfunctions of rat striatal dopaminergic neurons were examined using in vivo brain microdialysis. During transient forebrain ischemia, dopamine levels in dialysates were elevated 140-fold above controls but rapidly recovered after reperfusion. The increase in dopamine levels induced by high K+ stimulation after reperfusion was far smaller than that of the controls. Pretreatment with edaravone but not post-treatment dose-dependently improved the response to high K+ but not the massive dopamine increase during ischemia. These results suggest that free radicals produced during ischemia play more important roles in ischemia/reperfusion-induced dysfunctions of dopaminergic neurons. Keywords:: transient forebrain ischemia, dopamine release, edaravonehttp://www.sciencedirect.com/science/article/pii/S1347861319342847 |
| spellingShingle | Yoshinori Akiyama Soichi Miwa Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger Journal of Pharmacological Sciences |
| title | Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger |
| title_full | Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger |
| title_fullStr | Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger |
| title_full_unstemmed | Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger |
| title_short | Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger |
| title_sort | improvement of postischemic dopaminergic dysfunction by edaravone a free radical scavenger |
| url | http://www.sciencedirect.com/science/article/pii/S1347861319342847 |
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