Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?
Objective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21<sup>+0</sup> and 31<sup>+6</sup&g...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/9/2126 |
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| author | Il-Yeo Jang Hye-Ji Jung Ji-Hee Sung Suk-Joo Choi Soo-Young Oh Jung-Sun Kim Cheong-Rae Roh |
| author_facet | Il-Yeo Jang Hye-Ji Jung Ji-Hee Sung Suk-Joo Choi Soo-Young Oh Jung-Sun Kim Cheong-Rae Roh |
| author_sort | Il-Yeo Jang |
| collection | DOAJ |
| description | Objective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21<sup>+0</sup> and 31<sup>+6</sup> week of gestation due to preterm labor (PTL, <i>n</i> = 165), preterm premature rupture of membranes (PPROM, <i>n</i> = 202), or incompetent internal os of the cervix (IIOC, <i>n</i> = 44). The primary outcome measure was the rate of severe histological chorioamnionitis/funisitis. Secondary outcome measure was neonatal outcomes including neonatal and infant death, and neonatal composite morbidity. Results: The PPROM group demonstrated a higher rate of severe histological chorioamnionitis/funisitis compared to the PTL group (severe histological chorioamnionitis; PPROM, 66.3% vs. PTL, 49.1%, <i>p</i> = 0.001, severe funisitis; PPROM, 44.1% vs. PTL, 23.6%, <i>p</i> < 0.001) and this remained significant after multivariable analysis (severe histologic chorioamnionitis, OR 2.367, 95% CI 1.517–3.693; severe funisitis, OR 2.668, 95% CI 1.684–4.226). For neonatal outcomes only, a higher rate of patent ductus arteriosus was observed in the IIOC group compared to the PTL and PPROM groups (IIOC, 77.3% vs. PTL, 54.0% vs. PPROM, 54.0%, <i>p</i> = 0.043) and this remained significant after multivariable analysis. Conclusion: Indication of spontaneous preterm delivery might affect the placental inflammatory pathology and neonatal morbidity. |
| first_indexed | 2024-03-10T00:16:54Z |
| format | Article |
| id | doaj.art-505862e3196d475bb4a2bd05448171c2 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:16:54Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-505862e3196d475bb4a2bd05448171c22023-11-23T15:49:10ZengMDPI AGDiagnostics2075-44182022-09-01129212610.3390/diagnostics12092126Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes?Il-Yeo Jang0Hye-Ji Jung1Ji-Hee Sung2Suk-Joo Choi3Soo-Young Oh4Jung-Sun Kim5Cheong-Rae Roh6Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaDepartment of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, KoreaObjective: To investigate the severity of histologic chorioamnionitis /funisitis according to the indication for preterm delivery and their corresponding neonatal outcomes. Method: This study included 411 singleton women who delivered between 21<sup>+0</sup> and 31<sup>+6</sup> week of gestation due to preterm labor (PTL, <i>n</i> = 165), preterm premature rupture of membranes (PPROM, <i>n</i> = 202), or incompetent internal os of the cervix (IIOC, <i>n</i> = 44). The primary outcome measure was the rate of severe histological chorioamnionitis/funisitis. Secondary outcome measure was neonatal outcomes including neonatal and infant death, and neonatal composite morbidity. Results: The PPROM group demonstrated a higher rate of severe histological chorioamnionitis/funisitis compared to the PTL group (severe histological chorioamnionitis; PPROM, 66.3% vs. PTL, 49.1%, <i>p</i> = 0.001, severe funisitis; PPROM, 44.1% vs. PTL, 23.6%, <i>p</i> < 0.001) and this remained significant after multivariable analysis (severe histologic chorioamnionitis, OR 2.367, 95% CI 1.517–3.693; severe funisitis, OR 2.668, 95% CI 1.684–4.226). For neonatal outcomes only, a higher rate of patent ductus arteriosus was observed in the IIOC group compared to the PTL and PPROM groups (IIOC, 77.3% vs. PTL, 54.0% vs. PPROM, 54.0%, <i>p</i> = 0.043) and this remained significant after multivariable analysis. Conclusion: Indication of spontaneous preterm delivery might affect the placental inflammatory pathology and neonatal morbidity.https://www.mdpi.com/2075-4418/12/9/2126preterm deliverypreterm laborpreterm premature rupture of membranesincompetent internal os of the cervixplacental pathologyneonatal outcomes |
| spellingShingle | Il-Yeo Jang Hye-Ji Jung Ji-Hee Sung Suk-Joo Choi Soo-Young Oh Jung-Sun Kim Cheong-Rae Roh Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes? Diagnostics preterm delivery preterm labor preterm premature rupture of membranes incompetent internal os of the cervix placental pathology neonatal outcomes |
| title | Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes? |
| title_full | Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes? |
| title_fullStr | Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes? |
| title_full_unstemmed | Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes? |
| title_short | Do the Causes of Spontaneous Preterm Delivery Affect Placental Inflammatory Pathology and Neonatal Outcomes? |
| title_sort | do the causes of spontaneous preterm delivery affect placental inflammatory pathology and neonatal outcomes |
| topic | preterm delivery preterm labor preterm premature rupture of membranes incompetent internal os of the cervix placental pathology neonatal outcomes |
| url | https://www.mdpi.com/2075-4418/12/9/2126 |
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