Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute study
Objective: This study provided a rough estimate incidence of primary pediatric central diabetes insipidus (CDI) and examines the diagnostic factors between pediatric CDI and primary polydipsia (PP). Methods: We collected 27 patients with chief complaints of polyuria and/or polydipsia from January 20...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Endocrine and Metabolic Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666396122000024 |
| _version_ | 1811210442643603456 |
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| author | Miyuki Kitamura Junko Nishioka Takako Matsumoto Satoko Umino Atsuko Kawano Reo Saiki Yukari Tanaka Shuichi Yatsuga |
| author_facet | Miyuki Kitamura Junko Nishioka Takako Matsumoto Satoko Umino Atsuko Kawano Reo Saiki Yukari Tanaka Shuichi Yatsuga |
| author_sort | Miyuki Kitamura |
| collection | DOAJ |
| description | Objective: This study provided a rough estimate incidence of primary pediatric central diabetes insipidus (CDI) and examines the diagnostic factors between pediatric CDI and primary polydipsia (PP). Methods: We collected 27 patients with chief complaints of polyuria and/or polydipsia from January 2014 to December 2018 in the Department of Pediatrics, Our University Hospital. Results: We diagnosed type 1 diabetes mellitus (T1DM) in 16 patients, CDI in 5, PP in 5, and nocturnal enuresis in 1. The rough estimate incidence rate of pediatric CDI was 0.71/100,000/year. The diagnostic factors were a body mass index (BMI), urine gravity in the morning, urine volume and intake volume over 24 h, and bright spots in the posterior pituitary in a magnetic resonance image (MRI). The cutoff value of urine gravity in the morning for CDI was <1.010, with a sensitivity of 100 % and specificity of 100 %. The cutoff value of urine volume over 24 h for CDI was >2299 mL/m2, with a sensitivity of 100 % and specificity of 85.7 %. No pediatric CDI patients had the bright spot in the posterior pituitary of their MRI, using a type 1–weighted image; however, only 1 out of 4 PP patients did not show the bright spot. Conclusion: The rough estimate incidence of pediatric CDI with polydipsia and polyuria under the limited condition was 0.71/100,000/year, which was very low. Distinguishable factors between CDI patients and PP patients were BMI, urine and intake volumes over 24 h, and a bright spot on an MRI. Further studies with multiple institutes and more patients are required to confirm these findings. |
| first_indexed | 2024-04-12T04:55:38Z |
| format | Article |
| id | doaj.art-505944f2f4a447c1a499001fe82c3582 |
| institution | Directory Open Access Journal |
| issn | 2666-3961 |
| language | English |
| last_indexed | 2024-04-12T04:55:38Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Endocrine and Metabolic Science |
| spelling | doaj.art-505944f2f4a447c1a499001fe82c35822022-12-22T03:47:08ZengElsevierEndocrine and Metabolic Science2666-39612022-06-017100119Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute studyMiyuki Kitamura0Junko Nishioka1Takako Matsumoto2Satoko Umino3Atsuko Kawano4Reo Saiki5Yukari Tanaka6Shuichi Yatsuga7Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanDepartment of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanDepartment of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanDepartment of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanDepartment of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanDepartment of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanDepartment of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanCorresponding author.; Department of Pediatrics and Child Health, Kurume University School of Medicine, 67 Asahi-machi, Kurume City, Fukuoka 830-0011, JapanObjective: This study provided a rough estimate incidence of primary pediatric central diabetes insipidus (CDI) and examines the diagnostic factors between pediatric CDI and primary polydipsia (PP). Methods: We collected 27 patients with chief complaints of polyuria and/or polydipsia from January 2014 to December 2018 in the Department of Pediatrics, Our University Hospital. Results: We diagnosed type 1 diabetes mellitus (T1DM) in 16 patients, CDI in 5, PP in 5, and nocturnal enuresis in 1. The rough estimate incidence rate of pediatric CDI was 0.71/100,000/year. The diagnostic factors were a body mass index (BMI), urine gravity in the morning, urine volume and intake volume over 24 h, and bright spots in the posterior pituitary in a magnetic resonance image (MRI). The cutoff value of urine gravity in the morning for CDI was <1.010, with a sensitivity of 100 % and specificity of 100 %. The cutoff value of urine volume over 24 h for CDI was >2299 mL/m2, with a sensitivity of 100 % and specificity of 85.7 %. No pediatric CDI patients had the bright spot in the posterior pituitary of their MRI, using a type 1–weighted image; however, only 1 out of 4 PP patients did not show the bright spot. Conclusion: The rough estimate incidence of pediatric CDI with polydipsia and polyuria under the limited condition was 0.71/100,000/year, which was very low. Distinguishable factors between CDI patients and PP patients were BMI, urine and intake volumes over 24 h, and a bright spot on an MRI. Further studies with multiple institutes and more patients are required to confirm these findings.http://www.sciencedirect.com/science/article/pii/S2666396122000024Central diabetes insipidusPrimary polydipsiaPolydipsiaPolyuriaRough estimate incidence |
| spellingShingle | Miyuki Kitamura Junko Nishioka Takako Matsumoto Satoko Umino Atsuko Kawano Reo Saiki Yukari Tanaka Shuichi Yatsuga Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute study Endocrine and Metabolic Science Central diabetes insipidus Primary polydipsia Polydipsia Polyuria Rough estimate incidence |
| title | Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute study |
| title_full | Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute study |
| title_fullStr | Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute study |
| title_full_unstemmed | Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute study |
| title_short | Estimate incidence and predictive factors of pediatric central diabetes insipidus in a single-institute study |
| title_sort | estimate incidence and predictive factors of pediatric central diabetes insipidus in a single institute study |
| topic | Central diabetes insipidus Primary polydipsia Polydipsia Polyuria Rough estimate incidence |
| url | http://www.sciencedirect.com/science/article/pii/S2666396122000024 |
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