Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysis
ObjectiveTo explore the effect of new antiseizure medication on bone metabolism and bone mineral density in children.MethodsThe Chinese and English databases (PubMed, EMBASE, Cochrane Library, CNKI, Wanfang and VIP) were systematically searched for observational studies evaluating the effects of new...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1015691/full |
| _version_ | 1811220731497807872 |
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| author | La Zhuo Yong Zhang |
| author_facet | La Zhuo Yong Zhang |
| author_sort | La Zhuo |
| collection | DOAJ |
| description | ObjectiveTo explore the effect of new antiseizure medication on bone metabolism and bone mineral density in children.MethodsThe Chinese and English databases (PubMed, EMBASE, Cochrane Library, CNKI, Wanfang and VIP) were systematically searched for observational studies evaluating the effects of new antiseizure medication on bone metabolism and bone mineral density in children with epilepsy. The effects of new antiseizure medication on serum calcium, phosphorus, alkaline phosphatase, bone alkaline phosphatase, parathyroid hormone, 25-hydroxyvitamin D and bone mineral density in children were systematically evaluated.ResultsAfter systematic retrieval and screening, 12 studies with high literature quality (including 629 epileptic children and 627 control subjects) were included in the systematic evaluation. Meta-analysis showed that new antiseizure medication decreased bone mineral density (MD: −0.05, 95%CI, −0.09, −0.02; P = 0.004). From different kinds of antiseizure medication, levetiracetam can reduce blood phosphorus concentration in children (MD: −0.04; 95%CI, −0.07, −0.01). Oxcarbazepine increased serum alkaline phosphatase in children (MD:17.98; 95%CI, 10.43,25.53; P < 0.00001), and the increase intensity was significantly higher than that of levetiracetam (MD: 7.66; 95%CI, 0.29, 15.02; P = 0.04). In addition, oxcarbazepine can cause a significant increase in parathyroid hormone in children (MD: 7.52; 95%CI, 3.37,11.66; P = 0.0004), and 25 - hydroxyvitamin D was reduced, and the difference was statistically significant (MD:−2.18; 95%CI, −3.23, −1.13; P = 0.00006). However, the effects of new antiseizure medication on serum calcium and bone alkaline phosphatase in children were not statistically significantConclusionNew antiseizure medication have different effects on bone metabolism and bone mineral density in children with epilepsy, and the effects of different types of new antiseizure medication are different. |
| first_indexed | 2024-04-12T07:46:29Z |
| format | Article |
| id | doaj.art-505951eb287343a88553b1656eec85c7 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-12T07:46:29Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-505951eb287343a88553b1656eec85c72022-12-22T03:41:41ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-11-011010.3389/fped.2022.10156911015691Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysisLa Zhuo0Yong Zhang1Department of Pharmacy, Maternal and Child Health Hospital of Inner Mongolia Autonomous Region, Hohhot City, ChinaDepartment of Clinical Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, ChinaObjectiveTo explore the effect of new antiseizure medication on bone metabolism and bone mineral density in children.MethodsThe Chinese and English databases (PubMed, EMBASE, Cochrane Library, CNKI, Wanfang and VIP) were systematically searched for observational studies evaluating the effects of new antiseizure medication on bone metabolism and bone mineral density in children with epilepsy. The effects of new antiseizure medication on serum calcium, phosphorus, alkaline phosphatase, bone alkaline phosphatase, parathyroid hormone, 25-hydroxyvitamin D and bone mineral density in children were systematically evaluated.ResultsAfter systematic retrieval and screening, 12 studies with high literature quality (including 629 epileptic children and 627 control subjects) were included in the systematic evaluation. Meta-analysis showed that new antiseizure medication decreased bone mineral density (MD: −0.05, 95%CI, −0.09, −0.02; P = 0.004). From different kinds of antiseizure medication, levetiracetam can reduce blood phosphorus concentration in children (MD: −0.04; 95%CI, −0.07, −0.01). Oxcarbazepine increased serum alkaline phosphatase in children (MD:17.98; 95%CI, 10.43,25.53; P < 0.00001), and the increase intensity was significantly higher than that of levetiracetam (MD: 7.66; 95%CI, 0.29, 15.02; P = 0.04). In addition, oxcarbazepine can cause a significant increase in parathyroid hormone in children (MD: 7.52; 95%CI, 3.37,11.66; P = 0.0004), and 25 - hydroxyvitamin D was reduced, and the difference was statistically significant (MD:−2.18; 95%CI, −3.23, −1.13; P = 0.00006). However, the effects of new antiseizure medication on serum calcium and bone alkaline phosphatase in children were not statistically significantConclusionNew antiseizure medication have different effects on bone metabolism and bone mineral density in children with epilepsy, and the effects of different types of new antiseizure medication are different.https://www.frontiersin.org/articles/10.3389/fped.2022.1015691/fullchildrenbone mineral densitybone metabolismpediatricsnew antiseizure medication |
| spellingShingle | La Zhuo Yong Zhang Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysis Frontiers in Pediatrics children bone mineral density bone metabolism pediatrics new antiseizure medication |
| title | Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysis |
| title_full | Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysis |
| title_fullStr | Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysis |
| title_full_unstemmed | Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysis |
| title_short | Effects of new antiseizure medication on bone metabolism and bone mineral density in children: A meta-analysis |
| title_sort | effects of new antiseizure medication on bone metabolism and bone mineral density in children a meta analysis |
| topic | children bone mineral density bone metabolism pediatrics new antiseizure medication |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1015691/full |
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