Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure
Background Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood. Hepatokines, which are synthesized and secreted from the liver, have regulatory functions in peripheral tissues. Here, we aimed t...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.121.024901 |
| _version_ | 1797810180402970624 |
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| author | Ryohei Takeishi Tomofumi Misaka Yasuhiro Ichijo Shinji Ishibashi Mitsuko Matsuda Yukio Yamadera Himika Ohara Yukiko Sugawara Yu Hotsuki Koichiro Watanabe Fumiya Anzai Yu Sato Takamasa Sato Masayoshi Oikawa Atsushi Kobayashi Takayoshi Yamaki Kazuhiko Nakazato Akiomi Yoshihisa Yasuchika Takeishi |
| author_facet | Ryohei Takeishi Tomofumi Misaka Yasuhiro Ichijo Shinji Ishibashi Mitsuko Matsuda Yukio Yamadera Himika Ohara Yukiko Sugawara Yu Hotsuki Koichiro Watanabe Fumiya Anzai Yu Sato Takamasa Sato Masayoshi Oikawa Atsushi Kobayashi Takayoshi Yamaki Kazuhiko Nakazato Akiomi Yoshihisa Yasuchika Takeishi |
| author_sort | Ryohei Takeishi |
| collection | DOAJ |
| description | Background Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood. Hepatokines, which are synthesized and secreted from the liver, have regulatory functions in peripheral tissues. Here, we aimed to clarify the clinical impact of the hepatokine selenoprotein P in patients with HF. Methods and Results This is a prospective observational study that enrolled 296 participants consisting of 253 hospitalized patients with HF and 43 control subjects. First, we investigated selenoprotein P levels and found that its levels were significantly higher in patients with HF than in the controls. Next, patients with HF were categorized into 4 groups according to the presence of liver congestion using shear wave elastography and liver hypoperfusion by peak systolic velocity of the celiac artery, which were both assessed by abdominal ultrasonography. Selenoprotein P levels were significantly elevated in patients with HF with liver hypoperfusion compared with those without but were not different between the patients with and without liver congestion. Selenoprotein P levels were negatively correlated with peak systolic velocity of the celiac artery, whereas no correlations were observed between selenoprotein P levels and shear wave elastography of the liver. Kaplan‐Meier analysis demonstrated that patients with HF with higher selenoprotein P levels were significantly associated with increased adverse cardiac outcomes including cardiac deaths and worsening HF. Conclusions Liver‐derived selenoprotein P correlates with hepatic hypoperfusion and may be a novel target involved in cardiohepatic interactions as well as a useful biomarker for predicting prognosis in patients with HF. |
| first_indexed | 2024-03-13T07:05:18Z |
| format | Article |
| id | doaj.art-505a17f9735845f1847a7d45e08d088b |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-13T07:05:18Z |
| publishDate | 2022-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-505a17f9735845f1847a7d45e08d088b2023-06-06T12:11:51ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802022-06-01111110.1161/JAHA.121.024901Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart FailureRyohei Takeishi0Tomofumi Misaka1Yasuhiro Ichijo2Shinji Ishibashi3Mitsuko Matsuda4Yukio Yamadera5Himika Ohara6Yukiko Sugawara7Yu Hotsuki8Koichiro Watanabe9Fumiya Anzai10Yu Sato11Takamasa Sato12Masayoshi Oikawa13Atsushi Kobayashi14Takayoshi Yamaki15Kazuhiko Nakazato16Akiomi Yoshihisa17Yasuchika Takeishi18Department of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Clinical Laboratory Medicine Fukushima Medical University Hospital Fukushima JapanDepartment of Clinical Laboratory Medicine Fukushima Medical University Hospital Fukushima JapanDepartment of Clinical Laboratory Medicine Fukushima Medical University Hospital Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanDepartment of Cardiovascular Medicine Fukushima Medical University Fukushima JapanBackground Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood. Hepatokines, which are synthesized and secreted from the liver, have regulatory functions in peripheral tissues. Here, we aimed to clarify the clinical impact of the hepatokine selenoprotein P in patients with HF. Methods and Results This is a prospective observational study that enrolled 296 participants consisting of 253 hospitalized patients with HF and 43 control subjects. First, we investigated selenoprotein P levels and found that its levels were significantly higher in patients with HF than in the controls. Next, patients with HF were categorized into 4 groups according to the presence of liver congestion using shear wave elastography and liver hypoperfusion by peak systolic velocity of the celiac artery, which were both assessed by abdominal ultrasonography. Selenoprotein P levels were significantly elevated in patients with HF with liver hypoperfusion compared with those without but were not different between the patients with and without liver congestion. Selenoprotein P levels were negatively correlated with peak systolic velocity of the celiac artery, whereas no correlations were observed between selenoprotein P levels and shear wave elastography of the liver. Kaplan‐Meier analysis demonstrated that patients with HF with higher selenoprotein P levels were significantly associated with increased adverse cardiac outcomes including cardiac deaths and worsening HF. Conclusions Liver‐derived selenoprotein P correlates with hepatic hypoperfusion and may be a novel target involved in cardiohepatic interactions as well as a useful biomarker for predicting prognosis in patients with HF.https://www.ahajournals.org/doi/10.1161/JAHA.121.024901biomarkerheart failurehepatokineprognosisselenoprotein P |
| spellingShingle | Ryohei Takeishi Tomofumi Misaka Yasuhiro Ichijo Shinji Ishibashi Mitsuko Matsuda Yukio Yamadera Himika Ohara Yukiko Sugawara Yu Hotsuki Koichiro Watanabe Fumiya Anzai Yu Sato Takamasa Sato Masayoshi Oikawa Atsushi Kobayashi Takayoshi Yamaki Kazuhiko Nakazato Akiomi Yoshihisa Yasuchika Takeishi Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease biomarker heart failure hepatokine prognosis selenoprotein P |
| title | Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure |
| title_full | Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure |
| title_fullStr | Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure |
| title_full_unstemmed | Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure |
| title_short | Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure |
| title_sort | increases in hepatokine selenoprotein p levels are associated with hepatic hypoperfusion and predict adverse prognosis in patients with heart failure |
| topic | biomarker heart failure hepatokine prognosis selenoprotein P |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.121.024901 |
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