Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study
<p>Abstract</p> <p>Background</p> <p>Chronic inflammation appears to play a role in the pathogenesis of vascular dementia. Given the association between <it>Chlamydia pneumoniae </it>and stroke, the possibility exists that previous exposure to <it>C. p...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2004-10-01
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| Series: | BMC Neurology |
| Online Access: | http://www.biomedcentral.com/1471-2377/4/15 |
| _version_ | 1818835176837349376 |
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| author | Chernesky Max Mahony Jim Goldsmith Charlie H Molloy William Smieja Marek Chan Carusone Soo Gnarpe Judy Standish Tim Smith Stephanie Loeb Mark |
| author_facet | Chernesky Max Mahony Jim Goldsmith Charlie H Molloy William Smieja Marek Chan Carusone Soo Gnarpe Judy Standish Tim Smith Stephanie Loeb Mark |
| author_sort | Chernesky Max |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Chronic inflammation appears to play a role in the pathogenesis of vascular dementia. Given the association between <it>Chlamydia pneumoniae </it>and stroke, the possibility exists that previous exposure to <it>C. pneumoniae </it>may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of <it>C. pneumoniae </it>infection or inflammatory markers with vascular dementia.</p> <p>Methods</p> <p>28 case-patients with vascular dementia at a geriatric clinic and 24 caregiver-controls were tested for <it>C. pneumoniae </it>IgG and IgA antibodies. The association between vascular dementia and <it>C. pneumoniae </it>titres as well as inflammatory markers was estimated by using both conditional logistic regression and stratified logistic regression.</p> <p>Results</p> <p>When matched cases were compared to controls, there was no significant difference in elevated <it>C. pneumoniae </it>specific IgG antibodies (titre ≥ 1:32), odds ratio [OR] 1.3 (95% confidence intervals [CI] 0.3 to 6.0), p = 0.71, or in elevated <it>C. pneumoniae </it>specific IgA antibodies (titre ≥ 1:16), OR 2.0 (95%CI 0.5 to 8.0), p = 0.33 indicative of past or persistent <it>C. pneumoniae </it>infection. Similarly, no difference in high IgG or IgA antibody levels (IgG titre ≥ 1:512 or IgA titre ≥ 1:64) between the two groups, indicative of recent <it>C. pneumoniae </it>infection, was found, OR 0.4 (95%CI 0.1 to 2.1), p = 0.27. For C-reactive protein (CRP), the mean difference between 18 matched pairs (case – control) was – 3.33 mg/L. There was no significant difference between cases and controls when comparing log transformed values, OR 0.03 (95%CI 0.00 to 2.89), p = 0.13 or comparing CRP values above or below the median, OR 0.8 (95%CI 0.2 to 3.4), p = 0.71. For fibrinogen, the mean difference between pairs (case – control) was -0.07 g/L. There was no statistical difference between cases and controls when comparing log transformed values, OR 0.6 (95%CI 0.0 to 31.2), p = 0.79 or between fibrinogen values above and below the median, OR = 0.5 (95%CI 0.1 to 2.0), p = 0.50.</p> <p>Conclusion</p> <p>We found no evidence for a significant association between <it>C. pneumoniae </it>infection, inflammatory markers such as CRP and fibrinogen, and vascular dementia.</p> |
| first_indexed | 2024-12-19T02:46:33Z |
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| institution | Directory Open Access Journal |
| issn | 1471-2377 |
| language | English |
| last_indexed | 2024-12-19T02:46:33Z |
| publishDate | 2004-10-01 |
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| spelling | doaj.art-505b836b006e4884a07d48c2f5ca46aa2022-12-21T20:38:51ZengBMCBMC Neurology1471-23772004-10-01411510.1186/1471-2377-4-15Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control studyChernesky MaxMahony JimGoldsmith Charlie HMolloy WilliamSmieja MarekChan Carusone SooGnarpe JudyStandish TimSmith StephanieLoeb Mark<p>Abstract</p> <p>Background</p> <p>Chronic inflammation appears to play a role in the pathogenesis of vascular dementia. Given the association between <it>Chlamydia pneumoniae </it>and stroke, the possibility exists that previous exposure to <it>C. pneumoniae </it>may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of <it>C. pneumoniae </it>infection or inflammatory markers with vascular dementia.</p> <p>Methods</p> <p>28 case-patients with vascular dementia at a geriatric clinic and 24 caregiver-controls were tested for <it>C. pneumoniae </it>IgG and IgA antibodies. The association between vascular dementia and <it>C. pneumoniae </it>titres as well as inflammatory markers was estimated by using both conditional logistic regression and stratified logistic regression.</p> <p>Results</p> <p>When matched cases were compared to controls, there was no significant difference in elevated <it>C. pneumoniae </it>specific IgG antibodies (titre ≥ 1:32), odds ratio [OR] 1.3 (95% confidence intervals [CI] 0.3 to 6.0), p = 0.71, or in elevated <it>C. pneumoniae </it>specific IgA antibodies (titre ≥ 1:16), OR 2.0 (95%CI 0.5 to 8.0), p = 0.33 indicative of past or persistent <it>C. pneumoniae </it>infection. Similarly, no difference in high IgG or IgA antibody levels (IgG titre ≥ 1:512 or IgA titre ≥ 1:64) between the two groups, indicative of recent <it>C. pneumoniae </it>infection, was found, OR 0.4 (95%CI 0.1 to 2.1), p = 0.27. For C-reactive protein (CRP), the mean difference between 18 matched pairs (case – control) was – 3.33 mg/L. There was no significant difference between cases and controls when comparing log transformed values, OR 0.03 (95%CI 0.00 to 2.89), p = 0.13 or comparing CRP values above or below the median, OR 0.8 (95%CI 0.2 to 3.4), p = 0.71. For fibrinogen, the mean difference between pairs (case – control) was -0.07 g/L. There was no statistical difference between cases and controls when comparing log transformed values, OR 0.6 (95%CI 0.0 to 31.2), p = 0.79 or between fibrinogen values above and below the median, OR = 0.5 (95%CI 0.1 to 2.0), p = 0.50.</p> <p>Conclusion</p> <p>We found no evidence for a significant association between <it>C. pneumoniae </it>infection, inflammatory markers such as CRP and fibrinogen, and vascular dementia.</p>http://www.biomedcentral.com/1471-2377/4/15 |
| spellingShingle | Chernesky Max Mahony Jim Goldsmith Charlie H Molloy William Smieja Marek Chan Carusone Soo Gnarpe Judy Standish Tim Smith Stephanie Loeb Mark Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study BMC Neurology |
| title | Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study |
| title_full | Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study |
| title_fullStr | Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study |
| title_full_unstemmed | Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study |
| title_short | Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study |
| title_sort | lack of association between vascular dementia and chlamydia pneumoniae infection a case control study |
| url | http://www.biomedcentral.com/1471-2377/4/15 |
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