Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD

Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD

Abstract Background Parameters from maximal expiratory flow-volume curves (MEFVC) have been linked to CT-based parameters of COPD. However, the association between MEFVC shape and phenotypes like emphysema, small airways disease (SAD) and bronchial wall thickening (BWT) has not been investigated. Re...

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Bibliographic Details
Main Authors: Kenneth Verstraete, Nilakash Das, Iwein Gyselinck, Marko Topalovic, Thierry Troosters, James D. Crapo, Edwin K. Silverman, Barry J. Make, Elizabeth A. Regan, Robert Jensen, Maarten De Vos, Wim Janssens
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Respiratory Research
Subjects:
COPD
Computed tomography
Maximal expiratory flow-volume curve
Principal component analysis
Online Access:https://doi.org/10.1186/s12931-023-02318-4

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