2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices
Effective cancer treatment requires early detection and monitoring the development progress in a simple and affordable manner. Point-of care (POC) screening can provide a portable and inexpensive tool for the end-users to conveniently operate test and screen their health conditions without the neces...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/10/10/662 |
| _version_ | 1818303892441530368 |
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| author | Mohsen Mohammadniaei Huynh Vu Nguyen My Van Tieu Min-Ho Lee |
| author_facet | Mohsen Mohammadniaei Huynh Vu Nguyen My Van Tieu Min-Ho Lee |
| author_sort | Mohsen Mohammadniaei |
| collection | DOAJ |
| description | Effective cancer treatment requires early detection and monitoring the development progress in a simple and affordable manner. Point-of care (POC) screening can provide a portable and inexpensive tool for the end-users to conveniently operate test and screen their health conditions without the necessity of special skills. Electrochemical methods hold great potential for clinical analysis of variety of chemicals and substances as well as cancer biomarkers due to their low cost, high sensitivity, multiplex detection ability, and miniaturization aptitude. Advances in two-dimensional (2D) material-based electrochemical biosensors/sensors are accelerating the performance of conventional devices toward more practical approaches. Here, recent trends in the development of 2D material-based electrochemical biosensors/sensors, as the next generation of POC cancer screening tools, are summarized. Three cancer biomarker categories, including proteins, nucleic acids, and some small molecules, will be considered. Various 2D materials will be introduced and their biomedical applications and electrochemical properties will be given. The role of 2D materials in improving the performance of electrochemical sensing mechanisms as well as the pros and cons of current sensors as the prospective devices for POC screening will be emphasized. Finally, the future scopes of implementing 2D materials in electrochemical POC cancer diagnostics for the clinical translation will be discussed. |
| first_indexed | 2024-12-13T06:02:01Z |
| format | Article |
| id | doaj.art-505c62e5343544688260519480cbde9f |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-12-13T06:02:01Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-505c62e5343544688260519480cbde9f2022-12-21T23:57:18ZengMDPI AGMicromachines2072-666X2019-09-01101066210.3390/mi10100662mi101006622D Materials in Development of Electrochemical Point-of-Care Cancer Screening DevicesMohsen Mohammadniaei0Huynh Vu Nguyen1My Van Tieu2Min-Ho Lee3School of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06910, KoreaSchool of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06910, KoreaSchool of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06910, KoreaSchool of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06910, KoreaEffective cancer treatment requires early detection and monitoring the development progress in a simple and affordable manner. Point-of care (POC) screening can provide a portable and inexpensive tool for the end-users to conveniently operate test and screen their health conditions without the necessity of special skills. Electrochemical methods hold great potential for clinical analysis of variety of chemicals and substances as well as cancer biomarkers due to their low cost, high sensitivity, multiplex detection ability, and miniaturization aptitude. Advances in two-dimensional (2D) material-based electrochemical biosensors/sensors are accelerating the performance of conventional devices toward more practical approaches. Here, recent trends in the development of 2D material-based electrochemical biosensors/sensors, as the next generation of POC cancer screening tools, are summarized. Three cancer biomarker categories, including proteins, nucleic acids, and some small molecules, will be considered. Various 2D materials will be introduced and their biomedical applications and electrochemical properties will be given. The role of 2D materials in improving the performance of electrochemical sensing mechanisms as well as the pros and cons of current sensors as the prospective devices for POC screening will be emphasized. Finally, the future scopes of implementing 2D materials in electrochemical POC cancer diagnostics for the clinical translation will be discussed.https://www.mdpi.com/2072-666X/10/10/662point-of-carecancerdiagnosticsbiosensorelectrochemical2d materialgraphenemos<sub>2</sub>bi<sub>2</sub>se<sub>3</sub>mxene |
| spellingShingle | Mohsen Mohammadniaei Huynh Vu Nguyen My Van Tieu Min-Ho Lee 2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices Micromachines point-of-care cancer diagnostics biosensor electrochemical 2d material graphene mos<sub>2</sub> bi<sub>2</sub>se<sub>3</sub> mxene |
| title | 2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices |
| title_full | 2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices |
| title_fullStr | 2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices |
| title_full_unstemmed | 2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices |
| title_short | 2D Materials in Development of Electrochemical Point-of-Care Cancer Screening Devices |
| title_sort | 2d materials in development of electrochemical point of care cancer screening devices |
| topic | point-of-care cancer diagnostics biosensor electrochemical 2d material graphene mos<sub>2</sub> bi<sub>2</sub>se<sub>3</sub> mxene |
| url | https://www.mdpi.com/2072-666X/10/10/662 |
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