Macrophage Modification Strategies for Efficient Cell Therapy
Macrophages, important cells of innate immunity, are known for their phagocytic activity, capability for antigen presentation, and flexible phenotypes. Macrophages are found in all tissues and therefore represent an attractive therapeutic target for the treatment of diseases of various etiology. Gen...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1535 |
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| author | Anastasiya S. Poltavets Polina A. Vishnyakova Andrey V. Elchaninov Gennady T. Sukhikh Timur Kh. Fatkhudinov |
| author_facet | Anastasiya S. Poltavets Polina A. Vishnyakova Andrey V. Elchaninov Gennady T. Sukhikh Timur Kh. Fatkhudinov |
| author_sort | Anastasiya S. Poltavets |
| collection | DOAJ |
| description | Macrophages, important cells of innate immunity, are known for their phagocytic activity, capability for antigen presentation, and flexible phenotypes. Macrophages are found in all tissues and therefore represent an attractive therapeutic target for the treatment of diseases of various etiology. Genetic programming of macrophages is an important issue of modern molecular and cellular medicine. The controllable activation of macrophages towards desirable phenotypes in vivo and in vitro will provide effective treatments for a number of inflammatory and proliferative diseases. This review is focused on the methods for specific alteration of gene expression in macrophages, including the controllable promotion of the desired M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotypes in certain pathologies or model systems. Here we review the strategies of target selection, the methods of vector delivery, and the gene editing approaches used for modification of macrophages. |
| first_indexed | 2024-03-10T18:55:13Z |
| format | Article |
| id | doaj.art-505d0f1945d24797b2bcdebf49a7ba17 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:55:13Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-505d0f1945d24797b2bcdebf49a7ba172023-11-20T04:46:56ZengMDPI AGCells2073-44092020-06-0196153510.3390/cells9061535Macrophage Modification Strategies for Efficient Cell TherapyAnastasiya S. Poltavets0Polina A. Vishnyakova1Andrey V. Elchaninov2Gennady T. Sukhikh3Timur Kh. Fatkhudinov4National Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow 117997, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow 117997, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow 117997, RussiaNational Medical Research Center for Obstetrics, Gynecology and Perinatology Named after Academician V.I. Kulakov of Ministry of Healthcare of Russian Federation, 4 Oparina Street, Moscow 117997, RussiaDepartment of Histology, Cytology and Embryology, Peoples’ Friendship University of Russia, 6 Miklukho-Maklaya Street, Moscow 117198, RussiaMacrophages, important cells of innate immunity, are known for their phagocytic activity, capability for antigen presentation, and flexible phenotypes. Macrophages are found in all tissues and therefore represent an attractive therapeutic target for the treatment of diseases of various etiology. Genetic programming of macrophages is an important issue of modern molecular and cellular medicine. The controllable activation of macrophages towards desirable phenotypes in vivo and in vitro will provide effective treatments for a number of inflammatory and proliferative diseases. This review is focused on the methods for specific alteration of gene expression in macrophages, including the controllable promotion of the desired M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotypes in certain pathologies or model systems. Here we review the strategies of target selection, the methods of vector delivery, and the gene editing approaches used for modification of macrophages.https://www.mdpi.com/2073-4409/9/6/1535macrophagescell therapygenetic modificationinflammationpolarization |
| spellingShingle | Anastasiya S. Poltavets Polina A. Vishnyakova Andrey V. Elchaninov Gennady T. Sukhikh Timur Kh. Fatkhudinov Macrophage Modification Strategies for Efficient Cell Therapy Cells macrophages cell therapy genetic modification inflammation polarization |
| title | Macrophage Modification Strategies for Efficient Cell Therapy |
| title_full | Macrophage Modification Strategies for Efficient Cell Therapy |
| title_fullStr | Macrophage Modification Strategies for Efficient Cell Therapy |
| title_full_unstemmed | Macrophage Modification Strategies for Efficient Cell Therapy |
| title_short | Macrophage Modification Strategies for Efficient Cell Therapy |
| title_sort | macrophage modification strategies for efficient cell therapy |
| topic | macrophages cell therapy genetic modification inflammation polarization |
| url | https://www.mdpi.com/2073-4409/9/6/1535 |
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