Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats
Introduction Acute and chronic exposure to cadmium (Cd), due to its increased use and application in the industry, can result in the development of atherosclerosis, the occurrence of cardiomyopathy, cerebrovascular stroke, as well as carcinogenesis in some organs. The target for cadmium action is...
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Subjects: | |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821019052/type/journal_article |
| _version_ | 1827755040441368576 |
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| author | J. Jovanovic Mirkovic C. Alexopoulos Z. Jurinjak M. Jerkan N. Medojevic |
| author_facet | J. Jovanovic Mirkovic C. Alexopoulos Z. Jurinjak M. Jerkan N. Medojevic |
| author_sort | J. Jovanovic Mirkovic |
| collection | DOAJ |
| description |
Introduction
Acute and chronic exposure to cadmium (Cd), due to its increased use and application in the industry, can result in the development of atherosclerosis, the occurrence of cardiomyopathy, cerebrovascular stroke, as well as carcinogenesis in some organs. The target for cadmium action is thought to be the vascular endothelium.
Objectives
The aim of this study is to investigate the occurrence of oxidative stress on blood vessel endothelium induced by subacute administration of cadmium, as well as the protective power of alpha-lipoic acid (α-LA) supplementation on the Wistar strain albino rat model system.
Methods
After anesthesia of rats in the vivarium of the Scientific Research Center for Biomedicine, Faculty of Medicine in Niš, blood was collected by cardiac puncture and sent to the Clinic of Nephrology, Clinical Center in Niš, Serbia for determination of hematological parameters.
Results
According to the results of this study, it can be seen that the number of granulocytes is reduced due to cadmium intoxication, which is probably induced by the migration of neutrophils into tissues. The number of lymphocytes was increased due to subacute cadmium intoxication compared to the control group of animals. The positive efficacy of α-LA supplements in combating the adverse effects of cadmium on blood vessels is also confirmed.
Conclusions
Cadmium administration is thought to cause a systemic inflammatory reaction due to the formation of free radicals in the blood vessel endothelium. Administration of α-LA supplement confirms that it can be used as an antioxidant in the clinical management of many diseases and also in cadmium intoxication.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:57:39Z |
| format | Article |
| id | doaj.art-505d9779d12a405899a219b3e2b35fd6 |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:57:39Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-505d9779d12a405899a219b3e2b35fd62023-11-17T05:05:17ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S719S71910.1192/j.eurpsy.2021.1905Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of ratsJ. Jovanovic Mirkovic0C. Alexopoulos1Z. Jurinjak2M. Jerkan3N. Medojevic4Health Studies, The Academy of Applied Preschool Teaching and Health Studies, cuprija, SerbiaHealth Studies, The Academy of Applied Preschool Teaching and Health Studies, cuprija, SerbiaHealth Studies, The Academy of Applied Preschool Teaching and Health Studies, cuprija, SerbiaPhysicals Medicine, Health center Nis, nis, SerbiaUrology, Clinical Center Nis, nis, Serbia Introduction Acute and chronic exposure to cadmium (Cd), due to its increased use and application in the industry, can result in the development of atherosclerosis, the occurrence of cardiomyopathy, cerebrovascular stroke, as well as carcinogenesis in some organs. The target for cadmium action is thought to be the vascular endothelium. Objectives The aim of this study is to investigate the occurrence of oxidative stress on blood vessel endothelium induced by subacute administration of cadmium, as well as the protective power of alpha-lipoic acid (α-LA) supplementation on the Wistar strain albino rat model system. Methods After anesthesia of rats in the vivarium of the Scientific Research Center for Biomedicine, Faculty of Medicine in Niš, blood was collected by cardiac puncture and sent to the Clinic of Nephrology, Clinical Center in Niš, Serbia for determination of hematological parameters. Results According to the results of this study, it can be seen that the number of granulocytes is reduced due to cadmium intoxication, which is probably induced by the migration of neutrophils into tissues. The number of lymphocytes was increased due to subacute cadmium intoxication compared to the control group of animals. The positive efficacy of α-LA supplements in combating the adverse effects of cadmium on blood vessels is also confirmed. Conclusions Cadmium administration is thought to cause a systemic inflammatory reaction due to the formation of free radicals in the blood vessel endothelium. Administration of α-LA supplement confirms that it can be used as an antioxidant in the clinical management of many diseases and also in cadmium intoxication. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821019052/type/journal_articlecadmiumblood vesselantioxidantoxidative stressalpha-lipoic acid |
| spellingShingle | J. Jovanovic Mirkovic C. Alexopoulos Z. Jurinjak M. Jerkan N. Medojevic Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats European Psychiatry cadmium blood vessel antioxidant oxidative stress alpha-lipoic acid |
| title | Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats |
| title_full | Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats |
| title_fullStr | Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats |
| title_full_unstemmed | Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats |
| title_short | Protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats |
| title_sort | protective role of lipoic acid in the prevention of oxidative stress caused by cadmium in the vascular endothelium of rats |
| topic | cadmium blood vessel antioxidant oxidative stress alpha-lipoic acid |
| url | https://www.cambridge.org/core/product/identifier/S0924933821019052/type/journal_article |
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