Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes

Abstract Alpha-synuclein (aSyn) is a central player in the pathogenesis of synucleinopathies due to its accumulation in typical protein aggregates in the brain. However, it is still unclear how it contributes to neurodegeneration. Type-2 diabetes mellitus is a risk factor for Parkinson’s disease (PD...

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Main Authors: Ana Chegão, Mariana Guarda, Bruno M. Alexandre, Liana Shvachiy, Mariana Temido-Ferreira, Inês Marques-Morgado, Bárbara Fernandes Gomes, Rune Matthiesen, Luísa V. Lopes, Pedro R. Florindo, Ricardo A. Gomes, Patrícia Gomes-Alves, Joana E. Coelho, Tiago Fleming Outeiro, Hugo Vicente Miranda
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-022-00314-x

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https://doi.org/10.1038/s41531-022-00314-x

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