Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood Cells
Background Thrombotic microangiopathy encompasses a wide range of conditions, of which thrombotic thrombocytopenic purpura being a medical emergency requires prompt intervention, with schistocytes being a reliable morphological indicator of microvascular injury. However, there are conditi...
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| Format: | Article |
| Language: | English |
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Thieme Medical and Scientific Publishers Pvt. Ltd.
2023-09-01
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| Series: | Journal of Laboratory Physicians |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1764481 |
| _version_ | 1797755145276096512 |
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| author | Chethana Mannem Tuba Saher Gayathri Bilagali Ramdas |
| author_facet | Chethana Mannem Tuba Saher Gayathri Bilagali Ramdas |
| author_sort | Chethana Mannem |
| collection | DOAJ |
| description |
Background Thrombotic microangiopathy encompasses a wide range of conditions, of which thrombotic thrombocytopenic purpura being a medical emergency requires prompt intervention, with schistocytes being a reliable morphological indicator of microvascular injury. However, there are conditions other than thrombotic microangiopathic anemia where schistocytes can be seen in large numbers. These nonthrombotic microangiopathic conditions are broadly grouped under cytoskeletal abnormalities, mechanical damage, and thermal injuries. Automated methods in schistocyte evaluation have shown varied reproducibility requiring manual identification. International Council for Standardization in Hematology (ICSH) recommends standardized morphological criteria and quantitative assessment as a percentage after counting at least 1,000 red blood cells in optimal areas of smear to reduce interobserver variability. |
| first_indexed | 2024-03-12T17:42:36Z |
| format | Article |
| id | doaj.art-505e84e660d14cd6854b69b274aae506 |
| institution | Directory Open Access Journal |
| issn | 0974-2727 0974-7826 |
| language | English |
| last_indexed | 2024-03-12T17:42:36Z |
| publishDate | 2023-09-01 |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Journal of Laboratory Physicians |
| spelling | doaj.art-505e84e660d14cd6854b69b274aae5062023-08-03T23:21:12ZengThieme Medical and Scientific Publishers Pvt. Ltd.Journal of Laboratory Physicians0974-27270974-78262023-09-01150343744210.1055/s-0043-1764481Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood CellsChethana Mannem0Tuba Saher1Gayathri Bilagali Ramdas2Department of Pathology, Kempegowda Institute of Medical Sciences (Affiliated to Rajiv Gandhi University of Health Sciences), Bangalore, Karnataka, IndiaDepartment of Pathology, Kempegowda Institute of Medical Sciences (Affiliated to Rajiv Gandhi University of Health Sciences), Bangalore, Karnataka, IndiaDepartment of Pathology, Kempegowda Institute of Medical Sciences (Affiliated to Rajiv Gandhi University of Health Sciences), Bangalore, Karnataka, India Background Thrombotic microangiopathy encompasses a wide range of conditions, of which thrombotic thrombocytopenic purpura being a medical emergency requires prompt intervention, with schistocytes being a reliable morphological indicator of microvascular injury. However, there are conditions other than thrombotic microangiopathic anemia where schistocytes can be seen in large numbers. These nonthrombotic microangiopathic conditions are broadly grouped under cytoskeletal abnormalities, mechanical damage, and thermal injuries. Automated methods in schistocyte evaluation have shown varied reproducibility requiring manual identification. International Council for Standardization in Hematology (ICSH) recommends standardized morphological criteria and quantitative assessment as a percentage after counting at least 1,000 red blood cells in optimal areas of smear to reduce interobserver variability.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1764481ICSHschistocytesthrombotic microangiopathythromboticthrombocytopenic purpura |
| spellingShingle | Chethana Mannem Tuba Saher Gayathri Bilagali Ramdas Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood Cells Journal of Laboratory Physicians ICSH schistocytes thrombotic microangiopathy thrombotic thrombocytopenic purpura |
| title | Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood Cells |
| title_full | Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood Cells |
| title_fullStr | Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood Cells |
| title_full_unstemmed | Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood Cells |
| title_short | Traversing Their Path to the Peripheral Smear: The Journey of Traumatized Red Blood Cells |
| title_sort | traversing their path to the peripheral smear the journey of traumatized red blood cells |
| topic | ICSH schistocytes thrombotic microangiopathy thrombotic thrombocytopenic purpura |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1764481 |
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